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Application of andrographolide and preparation method of andrographolide rectal suppository

A technology of andrographolide and anal suppository, which is applied in the direction of medical preparations containing no active ingredients, medical preparations containing active ingredients, suppository delivery, etc., which can solve the problems of poor effect, poor solubility, and low bioavailability, etc. To achieve the effect of increasing bioavailability, improving compliance and improving efficacy

Inactive Publication Date: 2019-08-09
刘琦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the fat-soluble component of andrographolide, the solubility in water is poor, so that its bioavailability is low, and the effect of treating various diseases is not good

Method used

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  • Application of andrographolide and preparation method of andrographolide rectal suppository
  • Application of andrographolide and preparation method of andrographolide rectal suppository
  • Application of andrographolide and preparation method of andrographolide rectal suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An andrographolide anal suppository for treating acute kidney injury, comprising: 1.15 g of 34# semi-synthetic fatty acid glyceride, and 50 mg of andrographolide powder.

[0029] The preparation method of the above-mentioned andrographolide anal suppository: take the matrix according to the prescription, heat and melt it in a water bath at 80°C, add the prescribed amount of andrographolide powder (100 mesh sieve), stir and mix evenly with ultrasonic, cool to room temperature, and inject into the corresponding anal suppository mold , when the suppository is solidified, scrape off the overflowing part, demould, that is to say.

Embodiment 2

[0031] An andrographolide anal suppository for treating acute kidney injury, comprising: 1.10 g of 34# semi-synthetic fatty acid glyceride, and 25 mg of andrographolide powder.

[0032] The preparation method of above-mentioned andrographolide anal suppository is identical with embodiment 1.

Embodiment 3

[0034] An andrographolide anal suppository for treating acute kidney injury, comprising: 1.20 g of 34# semi-synthetic fatty acid glyceride, and 75 mg of andrographolide powder.

[0035] The preparation method of above-mentioned andrographolide anal suppository is identical with embodiment 1.

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Abstract

The invention discloses an application of andrographolide in preparation of medicines for treating acute kidney injury, and a preparation method of an andrographolide rectal suppository for treating the acute kidney injury. The method comprises the steps that 220-240 parts of semi-synthetic fatty glyceride is heated into a molten state, 5-15 parts of andrographolide powder is added and uniformly stirred, the mixture is cooled to room temperature and injecting a rectal suppository mould, and demoulding is carried out after the suppository is solidified. The effective components of the preparedandrographolide rectal suppository are easier to absorb, release is fast, and the efficacy time is long.

Description

technical field [0001] The present invention relates to the field of pharmaceutical use. More specifically, the present invention relates to a kind of application of andrographolide and the preparation method of andrographolide anal suppository. Background technique [0002] Acute kidney injury (acute kidney injury, AKI) is a common clinical critical symptom, and its incidence is increasing year by year, and it is one of the important causes of death in patients. Andrographolide (AD) is the main diterpene lactone active ingredient of Andrographis paniculata (Burm.f.) Nees. Andrographis paniculata is a plant of the Acanthaceae family, also known as golden herb, bitter gall grass, Indian grass, bitter grass, etc. As a medicinal plant with great application value, it has the functions of clearing heat and detoxifying, relieving pain and swelling, cooling blood and reducing inflammation. Modern pharmacological studies have shown that andrographolide has antiviral, antitumor, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/82A61K9/02A61P13/12A61K31/045
CPCA61K31/365A61K36/258A61K36/71A61K36/65A61K36/804A61K36/82A61K36/538A61K31/045A61K36/03A61K9/02A61K9/0031A61K47/14A61P13/12A61K2236/333A61K2236/39A61K2236/19A61K2236/53A61K2236/331A61K2236/55A61K2300/00
Inventor 刘琦
Owner 刘琦
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