26 results about "Semi synthetic" patented technology

The invention relates to the field of biological medicine preparation, in particular to a semi-synthesis preparation method of canagliflozin, which comprises the following steps: (1) under the condition that the pH value is 9.0-11.5, carrying out selective protection on lysine epsilon amino of a canagliflozin intermediate 36AA to obtain Boc-protected 36 peptide (BoC-36AA); (2) under the condition that the pH (Potential of Hydrogen) is 8.5 to 9.0, carrying out a reaction on side chain Glu-eicosandioic acid and the lysine alpha-amino group of the Boc-36AA to obtain 36-AA (SC-36AA) with a side chain; (3) carrying out a reaction on the SC-36AA and prolinamide, so as to obtain a canagliflozin precursor; and (4) cracking the canagliflozin precursor to obtain the canagliflozin. The preparation method is simple to operate, low in cost, high in yield and high in purity, the total reaction yield is more than 56%, and the HPLC (high performance liquid chromatography) purity is more than or equal to 99.6%.

In one aspect, the disclosure relates to immunogenic compositions comprising a semisynthetic saponin adjuvant (VSA) including, but not limited to, VSA-1 and VSA-2, derived from a Momordica saponin and at least one antigen. In a further aspect, the immunogenic compositions can include other known adjuvants, emulsifiers, and / or surface-active agents and can be formulated as liposomes, micelles, emulsions, and the like. Also disclosed are methods of eliciting effective immune responses to viral, bacterial, protozoal, and neoplastic diseases using the disclosed immunogenic compositions.

In one aspect, the disclosure relates to pneumococcal vaccines comprising a semisynthetic saponin adjuvant VSA-1. In one aspect, the disclosed vaccines elicit an immune response in a subject that is measurably higher than the response in an otherwise identical subject who receives a vaccine without the semisynthetic saponin adjuvant. In another aspect, the disclosed vaccines are useful across age groups and immunization can be achieved with fewer injections than for standard pneumococcal vaccines. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The present invention relates to methods for synthesizing osidiofundin analogs using mutants of osidiofundin containing aspartic acid (ASP7) or glutamic acid (GLU7) at position 7 instead of the previously characterized asparagine (ASN7). Selected semisynthetic analogs produced using the ASP7 and GLU7 mutants exhibited improved antifungal activity compared to the ASN7 osidiofundin mutant. The ASP7 and GLU7 mutants of osidiofundin and compositions thereof can be used to treat fungal infections, parasitic infections, and cancer.

The invention relates to a semi-synthesis method of semeglutide, and belongs to the field of chemical synthesis. The semi-synthesis method mainly comprises the following steps: (1) activating a side chain; (2) connecting an activated side chain with an Arg34GLP-1 (9-37) 29 peptide; (3) activating the dipeptide; (4) connection of the activated dipeptide and the side chain 29 peptide conjugate; (5) removing a protecting group to obtain a final product, namely a crude product of the semeglutide; meanwhile, pretreatment of materials and post-treatment of products are optimized in the synthesis process. On one hand, a side chain and dipeptide activation method which is short in time consumption and high in conversion rate is provided, on the other hand, an intermediate pretreatment and post-treatment method which is convenient, rapid, beneficial to reaction and beneficial to cost reduction and efficiency improvement is provided, the characters of substrates / products in all the steps are improved, cost reduction, production specification expansion and efficiency improvement in industrial production are facilitated, and the method is suitable for industrial production. And the method has very important significance on industrial production of a semeglutide bulk drug.

The application relates to the field of biological medicine preparation, in particular to a semi-synthetic preparation method of a cagrilintide, which comprises the following steps: (1) selectively protecting lysine epsilon amino groups of a cagrilintide intermediate 36AA under the condition that the pH is 9.0-11.5 to obtain a Boc-protected thirty-six peptide (Boc-36AA); (2) reacting side chain Glu-eicosanedioic acid with lysine alpha amino groups of the Boc-36AA under the condition that the pH is 8.5-9.0 to obtain a 36-AA with a side chain (SC-36AA); (3) reacting the SC-36AA with prolyl amide to obtain a cagrilintide precursor; and (4) cleaving the cagrilintide precursor to obtain the cagrilintide. The preparation method of the application has the advantages of simple operation, low cost, high yield and high purity, the total reaction yield is more than 56%, and the HPLC purity is greater than or equal to 99.6%.

The present invention relates to compounds for use in the treatment of a disease or condition caused by Zika virus, Dengue virus, West Nile virus, Chikungunya virus, O`nyong`nyong virus, Sindbis virus or SARS-CoV-2 virus.

This invention relates to the field of organic heat transfer fluid technology, providing a biphenyl-based semi-synthetic organic heat transfer fluid, its preparation method, and its applications. The biphenyl-based semi-synthetic organic heat transfer fluid comprises a biphenyl compound, polyethylbenzene, and an alkylnaphthalene, wherein the alkylnaphthalene includes ethylnaphthalene and / or propylnaphthalene; the content of polyethylbenzene in the biphenyl-based semi-synthetic organic heat transfer fluid is 20wt%–35wt%; the mass ratio of the biphenyl compound to the alkylnaphthalene is 1:(0.05–1). The biphenyl-based semi-synthetic organic heat transfer fluid provided by this invention has a simple composition, requires no functional additives, effectively reduces costs and the difficulty of controlling the product preparation process, and possesses a high auto-ignition point and closed-cup flash point, thus exhibiting better thermal stability. This ensures that all performance indicators fully meet the performance requirements of the L-QC320 type product in GB23971-2009, giving it strong market competitiveness.

The present invention discloses a semi-synthetic cutting fluid with excellent stability. By only using self-emulsifying esters as emulsifiers, on the basis of ensuring low foaming, resistance to hard water and lubrication, the number of raw materials can be reduced and the production process can be simplified. Moreover, by screening out a combination of basic additives, the aminolysis rate of the self-emulsifying ester can be significantly reduced, thereby achieving the purpose of extending the product warranty period. The present invention also discloses a preparation method and a usage method of a semi-synthetic cutting fluid with excellent stability. The key points of the present invention are: first, only self-emulsifying esters with better ammonia resistance are used as emulsifiers in the semi-synthetic cutting fluid; second, the selected combination of basic additives can also effectively reduce the aminolysis of the self-emulsifying ester. The combination of the above two aspects jointly extends the product warranty period.

Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more non-natural amino acids. Compositions, cells, engineered microorganisms, and kits for increasing retention of a non-natural nucleic acid encoding the non-natural amino acid in an engineered cell or semi-synthetic organism are also provided.

The present invention describes an aqueous semi-synthetic metalworking fluid comprising a base oil, an organic acid, an emulsifier, an additive concentrate, water, and a microbial growth control agent comprising a polyfunctional cyclic amine.

The invention relates to a process for the preparation of colchicine 1 from colchicoside 2 which comprises enzymatic conversion of colchicoside 2 to 3-O-demethylcolchicine 3, wherein the enzyme used is a cellulase. According to another aspect of the invention, 3-O-demethylcolchicine 3 can be converted to colchicine 1 using an alkylating agent. The invention also relates to a process for enriching the colchicine 1 content of extracts from plants belonging to the Colchicaceae family containing colchicine 1, colchicoside 2 and 3-O-demethylcolchicine 3, which comprises conversion by means of a colchicoside 2 cellulase to 3-O-demethylcolchicine 3, followed by conversion of 3-O-demethylcolchicine 3 to colchicine 1 using an alkylating agent.

The invention relates to the technical field of cutting fluid, and discloses a preparation method of semi-synthetic cutting fluid for black metal, and the cutting fluid comprises the following components by weight: 10 parts of water; 8 parts of monoethanolamine; 4 parts of diethanol amine; 4 parts of boric acid; 2 parts of undecanedioic acid; 1 part of RL50 tribasic acid; 0.2 part of benzotriazole; 2 parts of glycerol; 20 parts of naphthenic oil; 3 parts of tetrameric ricinoleate; 3 parts of tall oil; 3 parts of fatty alcohol-polyoxyethylene ether; 0.8 part of fatty alcohol polyoxyethylene ether carboxylic acid; 0.5 part of phosphate ester; 0.5 part of 21 carbon dibasic acid; 3 parts of N, N '-methylene dimorpholine; 34.8 parts of deionized water; and 0.2 part of a three-dimensional siloxane defoaming agent. The anti-rust and anti-corrosion cutting fluid has excellent anti-rust and anti-corrosion performance, can effectively prevent a machine tool and a machined part from being rusted and has comprehensive antibacterial characteristics, and the product can be used for a long time and hardly has decay and stink phenomena.

Disclosed are phytoecdysones and semisynthetic derivatives of phytoecdysones, intended to be used in treating impairment of the respiratory function in mammals, in particular in the context of a viral infection and more particularly during an infection by a coronavirus.

The invention relates to the gypsogenin-amine semisynthesis derivative compounds with anticancer activity and synthesis methods of these compounds. The gypsogenin-amine semisynthesis derivative compounds of the invention are derivatized from gypsogenin-amine aglycone.

The invention relates to the technical field of preparation of refrigerating machine oil compositions, in particular to an alkylbenzene semi-synthetic refrigerating machine oil composition for R290 refrigerants and a preparation method of the alkylbenzene semi-synthetic refrigerating machine oil composition, the alkylbenzene semi-synthetic refrigerating machine oil composition comprises base oil and additives, and the base oil is composed of mineral type lubricating oil fractions and alkylbenzene. The alkylbenzene semi-synthetic refrigerator oil composition for the R290 refrigerant is moderate in viscosity, relatively good in low-temperature performance, relatively low in two-phase separation temperature with the R290 refrigerant, and excellent in anti-oxidation stability and lubricity. The alkylbenzene semi-synthetic refrigerator oil composition for the R290 refrigerant has the kinematic viscosity of 20.8 mm < 2 > / s to 24.4 mm < 2 > / s at 40 DEG C, the pour point of-50 DEG C or below, the open flash point of 185 DEG C or above and the two-phase separation temperature of-50 DEG C or below, and is particularly suitable for a compressor with R290 as the refrigerant.

A composition comprising rhamnolipid compositions, said rhamnolipid compositions comprising (a) and (b), and said composition further comprising (c), wherein (a), (b), and (c) are as follows:wherein Rha is rhamnose;wherein each Cx is independently selected from an alkyl, aryl, heteroalkyl, heteroaryl, unsaturated alkenyl, and unsaturated heteroalkenyl;wherein each Cx independently has a carbon chain length from 4 to 22;wherein each M is independently selected from OH; O−X+ wherein X+ is a cation; OR1; alkyl, heteroalkyl; aryl; heteroaryl; hetero arylalkyl; arylalkyl; and tauryl;wherein R1 is selected from an alkyl, branched alkyl, and cyclic alkyl;and combinations thereof; and all possible stereoisomers thereof; andwherein (a) or (b) is at least about 25 wt % or greater of all rhamnolipids present in the compositions.

The application relates to the field of biological medicine preparation, and provides a semi-synthetic preparation method of semaglutide and a preparation method of a side chain of semaglutide. The semi-synthetic preparation method comprises the following steps: step 1, a solution of compound SMG-1 is mixed with a solution of compound III in the presence of a first base catalyst to obtain compound IV, wherein the first base catalyst is added in an amount that makes the pH of the SMG-1 solution 11.2-11.6; step 2, a solution of compound IV is mixed with a solution of compound SMG-3 in the presence of a coupling agent and a second base catalyst to obtain compound V through coupling, wherein the pH of step 2 is 9.5-10.0; and step 3, compound V is deprotected by using a deprotection agent, and finally semaglutide is obtained. The method has the advantages of fewer reaction steps, reduced cost, high purity and high yield of semaglutide, and is suitable for large-scale industrial production.

The present invention relates to the field of pharmaceutical technology, in particular to chondroitin sulfate polysaccharide, its semi-synthetic preparation method, and its use. The chondroitin sulfate polysaccharide metal salt provided by the present invention has anti-inflammatory effects and can be used to prepare anti-inflammatory disease drugs. Specifically, the chondroitin sulfate polysaccharide metal salt provided by the present invention has anti-inflammatory and bone-protecting effects and can be used to prepare anti-rheumatoid arthritis disease drugs and anti-osteoarthritis disease drugs. The present invention also provides a method for preparing the chondroitin sulfate polysaccharide metal salt, which can be obtained by semi-synthetic means with different sulfation degrees, and the method is simple and suitable for large-scale production.

The present invention relates to a lubricating fluid comprising one of water, one or more oils and a homocysteine or a derivative thereof, one of said homocysteine or a derivative thereof having extreme pressure and / or anti-wear and / or anti-biofilm properties. The invention also relates to the use of one of homocysteine or its derivatives in lubricating fluids, in particular in semisynthetic fluids. Finally, the invention relates to a method of lubricating a metal or a composite material comprising contacting the metal or the composite material with a lubricating fluid comprising one of water, one or more oils and homocysteine or a derivative thereof.

The present invention provides compounds derived from farnesene and methods of producing the compounds from farnesene. In addition, compositions and methods of using the compositions as personal care products and other consumer products are provided, wherein the compositions comprise compounds derived from farnesene.