372 results about "Semi synthetic" patented technology

Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to the subpopulation used for selection or displayed additional binding to a restricted population of other cells in the mixture. At least two phage antibodies appeared to display hithereto unknown staining patterns of B lineage cells. This approach provides a subtractive procedure to rapidly obtain human antibodies against known and novel surface antigens in their native configuration, expressed on phenotypically defined subpopulations of cells. Importantly, this approach does not depend on immunization procedures or the necessity to repeatedly construct phage antibody libraries.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substances (A) from the dosage form is at least partially delayed.

A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.

The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substances (A) from the dosage form is at least partially delayed.

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.

A semi-synthetic platelet gel comprising a platelet-rich plasma, at least one platelet activator, and a biocompatible polymer selected from the group comprising carbomers, polyalkylene glycols, poloxamers, polyesters, polyethers, polyanhydrides, polyacrylates, polyvinyl acetates, polyvinyl pyrrolidones, polysaccharides, and derivatives thereof. A method for preparing a semi-synthetic platelet gel comprising the steps of (a) mixing a platelet-rich plasma with at least one platelet activator, and, before the start of clot formation, (b) adding the mixture thus obtained to a biocompatible polymer selected from the group comprising carbomers, polyalkylene glycols, poloxamers, polyesters, polyethers, polyanhydrides, polyacrylates, polyvinyl acetates, polyvinyl pyrrolidones, polysaccharides, and derivatives thereof.

The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis / trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by controlling lengths of flow paths of the material through the applicator tip, forming one or more grooves in the applicator tip, providing a hollow, controlled thickness tip, and / or adding a cover surrounding at least a part but not all of an exposed area of the applicator tip.

A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.

The invention discloses a novel method for preparing tulathromycin and relates to a semi-synthetic macrolide antibiotic. The method comprises the following steps: simultaneously protecting 2'-hydroxyl and 6a-amino of desmethyl azithromycin with acetyl, then carrying out oxidation and epoxidation on 4''-hydroxy, then removing the protecting groups under alkaline alcohol solution conditions, and carrying out nucleophilic addition on 4''-epoxy group with n-propylamine to obtain the target compound tulathromycin. Compared with the prior art, the method for preparing tulathromycin has the advantages of simple process, mild conditions, high yield and the like, and is beneficial to industrial production.

The invention discloses a multi-effect semi-synthetic cutting solution. The solution is prepared by uniformly mixing the following raw material components in percentage by total mass of 100%: 10 to 14% of monoethanolamine for industrial use, 0.1 to 0.2% of benzotriazole for industrial use, 10 to 13% of boric acid for industrial use, 4 to 6% of phosphate-borate-containing water-based lubricant, 4 to 7% of tall oil fatty acid for industrial use, 8 to 12% of naphthenic oil K22, 2 to 4% of petroleum sodium sulfonate No.55, 0.5 to 1.5% of oleic acid polyoxyethylene ester for industrial use, 1.5 to 2% of 1,3,5-tri(2-hydroxyethyl)-hexahydrotriazine for industrial use, 0.1 to 0.2% of organic silicon defoamer for industrial use and the balance of water. The solution has high lubrication extreme pressure performance and is biodegradable and environment-friendly.

The invention provides a method for improving the granulation performance of a urine-based fertilizer and belongs to the field of compound fertilizer production. The method comprises the following steps that: a granulating loop is filled with a boning agent which is one or a mixture of a plurality of water soluble organic synthetic macromoleclar polymers, inorganic macromoleclar polymers or inorganic compound filters and natural or semisynthetic water soluble macromoleclar polymers or is added with agents capable of chemically reacting with urea to produce a thickener to obtain a viscous urea meltwater; and the viscous urea meltwater is delivered to a granulating machine to be mixed with a solid raw material and a return material brought by a return conveyer to be bonded and granulated. The method is simple, easy to implement and convenient to operate and can improve the granulation performance of the urine-based fertilizer, reduce returned material and greatly improve the production capacity of the device. In addition, by adding the bonding agent, the method improves the controlled-release effect of nitrogen and the utilization rate of the fertilizer and reduces the loss of nitrogen element in soil.

The invention relates to cutting fluid, in particular to semi-synthetic metal cutting fluid. The semi-synthetic metal cutting fluid is prepared by methyl levulinate, (R)-(+)-2,4-dyhydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, 2-oxo-1,5-disoidum glutarate dihydrate, 4-piperidone-3-carboxylate hydrochloride and trimethylsilylketene. The semi-synthetic metal cutting fluid has good cooling, anticorrosion, antirust and lubricating performance, service life of a knife can be prolonged effectively, and excellent machining accuracy can be realized; the semi-synthetic metal cutting fluid can play a role in safely and reliably protecting and inhibiting corrosion of nonferrous metal like aluminum and steel and ferrous metal, so that time and cost for subsequent treatment can be omitted; the semi-synthetic metal cutting fluid is suitable for being widely popularized and applied in the field of the cutting fluid.

The invention relates to the field of metal cutting liquids, in particular to an aluminium alloy cutting liquid with a long service life and a preparation method thereof. The semi-synthetic cutting liquid provided by the invention is prepared from 10 to 30 percent of mineral oil, 5 to 15 percent of alcohol amine, 5 to 12 percent of an emulsifying agent, 3 to 8 percent of an anti-rusting agent, 3 to 10 percent of a lubricating agent, 1 to 4 percent of a corrosion inhibitor, 1 to 4 percent of an extreme pressure agent, 0.5 to 1 percent of a defoaming agent, and 1 to 3 percent of a sterilizing agent. According to the formula of the aluminium alloy cutting liquid, conventional monoethanolamine, diethanol amine and triethanolamine serving as pH regulating agents are abandoned, and through a special compounding mode, the aluminium alloy cutting liquid has higher stability, and the cost is reduced. Secondly, the using amount of the extreme pressure agent is reduced by regulating the using amounts of various raw materials; moreover, excellent corrosion preventing and lubricating effects of the cutting liquid are maintained; the cutting liquid can be used for a long time; the replacement period of the cutting liquid provided by the invention is about one year; the cutting liquid is environment-friendly and has extremely low damage to a human body.

An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

The invention provides a half synthetic method for industrially producing vinpocetine on the premise of ensuring product purity and yield. Voacanga seed grown in Africa is used for extracting raw material-tabersonine required by synthesis. The tabersonine is synthesized into vinpocetine by four steps: 1) preparing vincadifformine; 2) preparing vincamine; 3) preparing vincamine acid; and 4) synthesizing the vinpocetine the content of which is 99%. The invention builds an integral process from tabersonine to vinpocetine, has the advatages of simple process, high yield and lower cost, and can realize the industrial production of vinpocetine on the premise of ensuring the product purity and yield.

The invention discloses a multifunctional semi-synthetic metal processing liquid and preparation method thereof. The multifunctional semi-synthetic metal processing liquid comprises, by weight, 5-20 parts of base oil, 8-10 parts of polyisobutylene succinic anhydride or the derivative of the same, 8-15 parts of borate, 2.5-8 parts of fatty acid methyl ester, 2 to 4 parts of rust inhibitor, 35 to 52 parts of water, 1 to 1.5 parts of amine, 0.5 to 0.8 part anti-hardening agent, 0.2 to 4.5 parts of copper corrosion inhibitor, 2 to 3 parts of aluminum corrosion inhibitor, 5 to 6 parts of coupling agents, 3 to 4 parts of fungicides and 0.2 to 0.3 part of defoaming agent. The metal processing liquid provided by the invention not only has excellent cooling effects, very good lubricating effects and extreme pressure property, excellent high temperature stability and low temperature stability, but also generates little foam. The processing liquid is an environment friendly product which can be used for the cutting and grinding operation with medium and high difficulties in the high-speed cutting and large piece cutting.

The invention relates to semi-synthetic biologic molecules which are conjugates of GLP-1 peptides and human multimeric proteins or protein fragments, such as an antibody Fc joined by a non-peptidyl bond. The constructs demonstrate biological activity and are useful making therapeutic compositions and therapeutic formulations for use in treating diseases characterized by lack of glycemic control.

A system for creating a water repellant coating on a windshield, comprises a water repellant surface treatment comprising a silicone-containing compound, and a water repellant wiper blade comprising a natural or synthetic or semi-synthetic rubber squeegee body and a water repellant coating comprising a hydrophobic polymeric film former and a hydrophobicity-enabling agent such as polyalkylsiloxane (modified or non-modified) silicone fluids. The polymeric film can be made from a compound selected from the group consisting of polyol resins, urethane resins, fluorine resins, epoxy resins, and silicone resins and may further include a friction reducing agent selected from the group consisting of graphite, PTFE, and molybdenum disulfide powders.

The present application relates to isolated amino acid sequence comprising multiple repeats of a semi-synthetic spider silk protein domain, or any functional homolog, variant, derivative, fragment or mutant thereof. The amino acid sequence of the invention further comprises an N-terminal region and a C-terminal region. The invention further provides a nucleic acid encoding the amino acid sequence of the invention, an expression vector comprising said nucleic acid, a host cell transformed with said expression vector, a recombinant spider silk protein thus produced and a fiber composed of the recombinant spider silk protein. The invention further encompasses a composition comprising as an active ingredient said amino acid sequence or any said recombinant protein or fiber comprising the same. Lastly, the invention relates to an article comprising at least one fiber composed of said recombinant spider silk protein.