88 results about "Biphenyl compound" patented technology

The invention discloses a triazine biphenyl compound, a composition, a cured product as well as a preparation method and application of the triazine biphenyl compound, the composition and the cured product. The compound is phenolic resin with a triazine biphenyl structure obtained through condensation polymerization of p-cyanobiphenol; the phenolic resin respectively reacts with an epichlorohydrin compound and an acyl chloride compound to obtain epoxy resin and active ester with a triazine biphenyl structure, and the epoxy resin and the active ester can be self-cured or cured under the action of an imidazole accelerator; in the preparation process, triazine ring (containing nitrogen) is introduced as a node, trifunctional epoxy resin with a rigid aromatic structure as an arm and an active ester curing agent (the same skeleton) are prepared into a thermosetting cross-linked network by adopting a non-polar cross-linking scheme, and a three-dimensional network intrinsic microporous structure is formed through in-situ cross-linking regulation and control of a rigid long-arm branched unit. Further, the bottlenecks of low dielectric property, high temperature resistance, flame retardance and the like are broken through, and the cured material has the characteristics of excellent flame retardance, high temperature resistance and low dielectric property.

A pyrazine thio-biphenyl compound and its application, specifically discloses the compound of formula (II) or a pharmaceutically acceptable salt thereof.

The invention discloses a biphenyl compound as well as a preparation method and application thereof. The biphenyl compound disclosed by the invention is obtained by being separated from a fermentation solution of a fungus Aspergillus candidus HNNU0546 derived from marine cold spring sediments. The biphenyl compound disclosed by the invention has relatively remarkable activity of resisting alternaria solani and pineapple black heart pathogen, so that the biphenyl compound has a good application prospect in the aspect of preparing pesticides for resisting crop diseases and fungi.

The invention provides a diketone biphenyl compound serving as a VAV1 degradation agent and application of the diketone biphenyl compound. Specifically provided are a compound represented by formula (I), a tautomer, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof. The compound provided by the invention is good in drug effect and can be used for preparing drugs for treating or preventing VAV1 related diseases.

The invention relates to a synthesis method of a fluxapyroxad intermediate. The synthesis method comprises the step of reacting a compound Ia and a compound Ib in the presence of a catalyst and alkali. According to the method disclosed by the invention, the biphenyl compound shown in the formula I can be obtained with high yield. Moreover, the catalyst used in the invention is low in preparation cost and low in toxicity, the reaction does not need to be strictly controlled to be carried out in an anhydrous and oxygen-free environment, and the operation is simpler. Therefore, compared with the existing method, the preparation method disclosed by the invention is more efficient, simpler, safer and more friendly. # imgabs0 #

A method for making the benzoate salt of 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]-2-fluoro-benzonitrile, designated compound (A), and methods for using compound (A) are provided.

The present application relates to a biphenyl compound, and a pharmaceutical composition thereof and the use thereof. Specifically, provided is a biphenyl compound as represented by formula (I), which can be used in the preparation of a drug, particularly in the preparation of a drug for preventing and / or treating diseases or conditions caused by or associated with the dysregulation of lymphocyte development or activity. Each group in formula (I) is as defined in the description.

Compounds of formula (I) capable of modulating store-operated calcium entry (SOCE) The present disclosure also relates to compositions and uses of compounds of formula (I) for treating disease conditions that depend on increased / decreased SOCE activity.

The present application relates to the technical field of oil and gas reservoir fracturing stimulation, discloses a phenolic resin biphenyl compound composition and application, an epoxy resin product and a preparation method thereof.The composition comprises a curing agent, a reinforcing agent and water; the curing agent is a bisphenol phenolic resin, the bisphenol phenolic resin comprises structural unit A shown in formula I and structural unit B shown in formula II; the reinforcing agent has a structure shown in formula III; the content of the structural unit A is 0-100 wt% and the content of the structural unit B is 0-100 wt% based on the total weight of the bisphenol phenolic resin.The composition comprises a crosslinked polymer and a reinforcing agent with a specific structure, which serves as a curing agent, and the prepared epoxy resin product has excellent high-temperature resistance and deformation resistance.

The present disclosure provides a 18F-labeled biphenyl compound, its intermediate, preparation method, pharmaceutical composition and application. The biphenyl compound disclosed in the present disclosure has a significant inhibitory effect on PD-1 and / or PD-L1, can effectively alleviate or treat cancer and other related diseases, and can be used in PET tumor imaging technology.

The present invention discloses a method for synthesizing 2-nitro-1,1'-biphenyl compounds and their applications. Using 2-nitro-1,2,3,6-tetrahydro-1,1'-biphenyl compounds as raw materials, a reaction is carried out in the presence of a catalyst, a solvent and an oxidant to obtain 2-nitro-1,1'-biphenyl compounds. The synthesis method of the present invention has a reaction yield of 90.2%-94.8%, and the dehydrogenation aromatization reaction involved has high selectivity, low cost, easy operation, less pollution and is suitable for industrial production.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

The invention relates to the technical field of medicines, in particular to a biphenyl compound and application thereof in resisting clinical drug-resistant bacteria. The biphenyl compound provided by the invention has a structure as shown in a formula I: # imgabs0 #, in the formula I, R1 is H, R2 is C (CH3) 3, and R3 is H; or R1 = C (CH3) 3, R2 = H, and R3 = C (CH3) 3. The biphenyl compound provided by the invention can effectively inhibit various clinical drug-resistant bacteria, and has great application potential.

The invention relates to the technical field of pesticides, in particular to a pentafluorosulfenyl-containing biphenyl compound, a composition and application of the pentafluorosulfenyl-containing biphenyl compound. The pentafluorosulfenyl-containing biphenyl compound is a compound as shown in a formula I, or a stereoisomer, a tautomer, an isotope derivative and a pesticide acceptable salt thereof. The biphenyl compound containing the pentafluorothio group shows an excellent prevention and control effect on various pests, particularly tetranychus cinnabarinus, tetranychus urticae, tetranychus shennieri, panonychus citri and the like, and compared with compounds disclosed in the prior art, the biphenyl compound containing the pentafluorothio group has better insecticidal or acaricidal activity and is safe to crops.

Provided is a compound having excellent plant disease control efficacy. The compound represented by formula (A) can be used for controlling plant diseases.

The invention belongs to the field of medicinal chemistry, and particularly relates to biphenyl compounds and application of the biphenyl compounds in preparation of compounds similar to colopivir. According to the synthesis route of the colopivir, the biphenyl intermediate compound is utilized, and the colopivir is prepared with high yield from cheap and easily available starting materials by adopting a simple reaction type and a cheap conventional reagent. As a one-pot synthesis strategy is adopted twice in the route, the synthesis efficiency and the operation convenience are greatly improved, the time, material and labor costs are reduced, and the method has a wide commercial development prospect.

The present invention provides a compound having excellent plant disease control efficacy. The compound represented by formula (A) can be used for plant disease control.

The invention discloses a biphenyl-diketopiperazine indole alkaloid hybrid compound, which is separated from a fermentation product of a strain Aspergillus candidus HNNU0546, and has a skeleton molecule formed by hybridizing rare diketopiperazine indole alkaloid with biphenyl molecules through an isopentenylation branch chain, and the biphenyl compound can obviously inhibit the activity of crop disease fungi.

The invention discloses a modified sulfonated polyether-ether-ketone proton exchange membrane as well as a preparation method and application thereof. The modified sulfonated polyetheretherketone proton exchange membrane comprises sulfonated polyetheretherketone with the sulfonation degree of 85-90% and a triazine biphenyl compound with an isocyanate group. The mass ratio of the sulfonated polyether ether ketone to the triazine biphenyl compound with the isocyanate group is 100: (5-10). According to the proton exchange membrane, sulfonated polyether-ether-ketone is modified through a triazine biphenyl compound with an isocyanate group, under the condition that good proton conductivity is kept, the mechanical strength and dimensional stability of the high-sulfonation-degree polyether-ether-ketone proton exchange membrane can be effectively improved, the vanadium ion permeability is reduced, and the proton exchange membrane has good comprehensive use performance. The diaphragm can be used for a hydrogen fuel cell or a hydrogen production electrolytic cell.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

The present application relates to the technical field of separation and purification of Schizonepeta tenuifolia Briq, and relates to a biphenyl compound in Schizonepeta tenuifolia Briq, a preparation method thereof and application of the biphenyl compound as an anti-inflammatory drug. The biphenyl compound in Schizonepeta tenuifolia Briq is obtained by the following steps: soaking Schizonepeta tenuifolia Briq, heating and reflux extraction, recovering and concentrating under reduced pressure, obtaining total extract of Schizonepeta tenuifolia Briq, extracting and concentrating with petroleum ether, dichloromethane and ethyl acetate, obtaining a dichloromethane part extract, gradient elution separation of the dichloromethane part extract, gradient elution separation of the fourth fraction of the obtained eight fractions, gradient elution separation of the third fraction of the obtained six fractions, gradient elution separation of the fifth fraction of the obtained eight fractions, purification and separation of the eluate, and collection of the eluate, and the biphenyl compound in Schizonepeta tenuifolia Briq is obtained at 16.4 minutes. The present application discloses the biphenyl compound in Schizonepeta tenuifolia Briq for the first time, and in vitro anti-inflammatory pharmacodynamic experiments are carried out, which prove that the biphenyl compound has a certain inhibitory effect on RAW264.7 cells and can be applied to preparation of anti-inflammatory drugs.

The present disclosure also relates to a pharmaceutical composition that comprises the compound as an active ingredient.

The invention relates to organic electroluminescent materials and devices. An ortho-substituted biphenyl compound having one or more bicarbazole linkages is provided. Formulations comprising these ortho-substituted biphenyl compounds are also provided. In addition, OLEDs and related consumer products using these ortho-substituted biphenyl compounds are provided.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for catalytically synthesizing a dibenzo [b, d] azepine compound by using an N-heterocyclic carbene oxazoline cyclic palladium compound. The invention aims to provide a novel synthesis method of a dibenzo [b, d] azepine compound, and particularly relates to a method for synthesizing the dibenzo [b, d] azepine compound by using a high-catalytic-activity N-heterocyclic carbene oxazoline cyclic palladium compound as a catalyst through a carbon-nitrogen / carbon-carbon bond cascade reaction. The 2, 2 '-dihalogenated biphenyl compound and an N-alkyl substituted allylamine compound are directly synthesized into the dibenzo [b, d] azepine compound in one step. The catalyst used in the invention has high catalytic activity, and the reaction has good compatibility of products and functional groups; the catalyst is easy to synthesize, and the raw materials of the 2, 2 '-dihalogenated biphenyl compound used in the synthesis route are cheap and easy to obtain.

Disclosed herein is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also disclosed herein is a pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive. Further disclosed herein is a method for preventing or treating a disease or condition through the modulation of the glucagon receptor using a compound of formula (I), or a pharmaceutically acceptable salt thereof.

A novel disulfide biphenol ether compound and its preparation method and application for treating inflammatory skin diseases, the structural formula of the disulfide biphenol ether compound is: biphenyl diester is first dissolved in anhydrous tetrahydrofuran solvent, lithium aluminum hydroxide is added, quenched, filtered, extracted with dichloromethane, water is added to quench the reaction, extracted with dichloromethane, the organic phases are combined, after removing residual moisture, the reduced pressure rotary evaporation and recrystallization are removed to obtain intermediate 2; intermediate 2 and potassium thioacetate are added to solvent N, N-dimethylformamide and extracted, the organic phases are combined, and the solvent is evaporated and concentrated to obtain a light intermediate 3; intermediate 3 is dissolved in anhydrous methanol, sodium methoxide is added, stirred, extracted with ethyl acetate, and the organic phases are combined to obtain. The disulfide biphenyl compound prepared by the present invention has good anti-inflammatory ability, can effectively reduce inflammatory infiltration in tissue, improve the inflammatory phenotype of animal models, and can prevent and treat inflammatory skin diseases.

Disclosed in the present invention are a biphenyl compound and the use thereof. The present invention provides a biphenyl compound represented by formula I or formula II, a pharmaceutically acceptable salt and solvate thereof or a solvate of the pharmaceutically acceptable salt thereof. The biphenyl compound has an inhibitory effect on PD-1 / PD-L1 binding, and thus can be used for treating or diagnosing related diseases such as tumors.

This invention discloses a synthetic method for Cochlearol B, belonging to the field of natural product technology. The method uses commercially available 2-bromo-3-methoxy-4-hydroxyacetophenone and 2,5-dihydroxyphenylboronic acid as raw materials. After protection with tert-butyldimethylchlorosilane, Wittig olefination, and Suzuki cross-coupling, a biphenyl compound is obtained. Following a Wacker-type cross-coupling tandem reaction, the substrate is protected with methoxymethylene bromide, and the tert-butyldimethylsilyl group is removed with a fluorine reagent. Then, under high-valent iodine reagent conditions, phenol is dearomatized in the next step. After reduction, a [2+2] cycloaddition reaction occurs under light to obtain a highly substituted cyclobutane product. Finally, through reduction, Wittig olefination, epoxidation, and epoxide ring-opening rearrangement, the chemical synthesis of Cochlearol B can be achieved. This synthetic route has the advantages of being simple, efficient, easy to operate, and low-cost, making it suitable for the large-scale synthesis of Cochlearol B and providing an important material basis for the evaluation of the bioactivity of the natural product Cochlearol B.

Provided are a diketone biphenyl compound as a VAV1 degradation agent, and a use thereof. Specifically, provided are a compound represented by formula (I), and a tautomer, stereoisomer, pharmaceutically acceptable salt or prodrug thereof. The provided compound has good efficacy, and can be used for preparing a drug for treating or preventing VAV1-related diseases.

The invention provides application of a biphenyl compound in inhibiting activity of alpha-glucosidase and application of the biphenyl compound in reducing blood sugar, and belongs to the technical field of biological medicine. The invention provides an application of a biphenyl compound as an alpha-glucosidase inhibitor and an application of the biphenyl compound in reducing the blood sugar level. The biphenyl compound can significantly inhibit the activity of alpha-glucosidase, the IC50 value of THB is 11.52 [mu] M, the dissociation constant is 3.91 * 10 <-5 > M, the inhibition effect of THB on alpha-glucosidase has concentration dependence, and the highest inhibition rate reaches 96.50%. The safety and in-vivo hypoglycemic activity of the biphenyl compound are evaluated, the postprandial blood sugar level can be effectively reduced in vivo, and the biphenyl compound has the potential of serving as a diabetes treatment medicine and the value of preparing auxiliary hypoglycemic food.