32 results about "Biphenyl compound" patented technology

The invention provides a diketone biphenyl compound serving as a VAV1 degradation agent and application of the diketone biphenyl compound. Specifically provided are a compound represented by formula (I), a tautomer, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof. The compound provided by the invention is good in drug effect and can be used for preparing drugs for treating or preventing VAV1 related diseases.

The present application relates to a biphenyl compound, and a pharmaceutical composition thereof and the use thereof. Specifically, provided is a biphenyl compound as represented by formula (I), which can be used in the preparation of a drug, particularly in the preparation of a drug for preventing and / or treating diseases or conditions caused by or associated with the dysregulation of lymphocyte development or activity. Each group in formula (I) is as defined in the description.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

Provided is a compound having excellent plant disease control efficacy. The compound represented by formula (A) can be used for controlling plant diseases.

The invention belongs to the field of medicinal chemistry, and particularly relates to biphenyl compounds and application of the biphenyl compounds in preparation of compounds similar to colopivir. According to the synthesis route of the colopivir, the biphenyl intermediate compound is utilized, and the colopivir is prepared with high yield from cheap and easily available starting materials by adopting a simple reaction type and a cheap conventional reagent. As a one-pot synthesis strategy is adopted twice in the route, the synthesis efficiency and the operation convenience are greatly improved, the time, material and labor costs are reduced, and the method has a wide commercial development prospect.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

The present application relates to the technical field of separation and purification of Schizonepeta tenuifolia Briq, and relates to a biphenyl compound in Schizonepeta tenuifolia Briq, a preparation method thereof and application of the biphenyl compound as an anti-inflammatory drug. The biphenyl compound in Schizonepeta tenuifolia Briq is obtained by the following steps: soaking Schizonepeta tenuifolia Briq, heating and reflux extraction, recovering and concentrating under reduced pressure, obtaining total extract of Schizonepeta tenuifolia Briq, extracting and concentrating with petroleum ether, dichloromethane and ethyl acetate, obtaining a dichloromethane part extract, gradient elution separation of the dichloromethane part extract, gradient elution separation of the fourth fraction of the obtained eight fractions, gradient elution separation of the third fraction of the obtained six fractions, gradient elution separation of the fifth fraction of the obtained eight fractions, purification and separation of the eluate, and collection of the eluate, and the biphenyl compound in Schizonepeta tenuifolia Briq is obtained at 16.4 minutes. The present application discloses the biphenyl compound in Schizonepeta tenuifolia Briq for the first time, and in vitro anti-inflammatory pharmacodynamic experiments are carried out, which prove that the biphenyl compound has a certain inhibitory effect on RAW264.7 cells and can be applied to preparation of anti-inflammatory drugs.

The present disclosure also relates to a pharmaceutical composition that comprises the compound as an active ingredient.

Disclosed in the present invention are a biphenyl compound and the use thereof. The present invention provides a biphenyl compound represented by formula I or formula II, a pharmaceutically acceptable salt and solvate thereof or a solvate of the pharmaceutically acceptable salt thereof. The biphenyl compound has an inhibitory effect on PD-1 / PD-L1 binding, and thus can be used for treating or diagnosing related diseases such as tumors.

Provided are a diketone biphenyl compound as a VAV1 degradation agent, and a use thereof. Specifically, provided are a compound represented by formula (I), and a tautomer, stereoisomer, pharmaceutically acceptable salt or prodrug thereof. The provided compound has good efficacy, and can be used for preparing a drug for treating or preventing VAV1-related diseases.

The invention provides a catalyst and a preparation method thereof, and a preparation method of a biphenyl compound. The catalyst comprises a carrier, the carrier comprises a modified molecular sieve, and the modified molecular sieve is obtained by modifying a molecular sieve through alkali metal salt; and, an active ingredient, the active ingredient comprising a noble metal cluster; wherein the active component is loaded on the surface and / or inside the modified molecular sieve; in addition, at least part of noble metal clusters are encapsulated in pore channels of the modified molecular sieve. The catalyst can be used for preparing biphenyl compounds. The preparation method of the catalyst is simple and easy to implement, raw materials are easy to obtain, and the catalyst is suitable for mass production.

This invention relates to the field of organic heat transfer fluid technology, providing a biphenyl-based semi-synthetic organic heat transfer fluid, its preparation method, and its applications. The biphenyl-based semi-synthetic organic heat transfer fluid comprises a biphenyl compound, polyethylbenzene, and an alkylnaphthalene, wherein the alkylnaphthalene includes ethylnaphthalene and / or propylnaphthalene; the content of polyethylbenzene in the biphenyl-based semi-synthetic organic heat transfer fluid is 20wt%–35wt%; the mass ratio of the biphenyl compound to the alkylnaphthalene is 1:(0.05–1). The biphenyl-based semi-synthetic organic heat transfer fluid provided by this invention has a simple composition, requires no functional additives, effectively reduces costs and the difficulty of controlling the product preparation process, and possesses a high auto-ignition point and closed-cup flash point, thus exhibiting better thermal stability. This ensures that all performance indicators fully meet the performance requirements of the L-QC320 type product in GB23971-2009, giving it strong market competitiveness.

The present application relates to a kind of visible light catalytic adjacent wood reaction palladium / perovskite material and preparation method and application.The present application belongs to the cross field of inorganic chemistry, organic chemistry, material chemistry.The palladium / perovskite material prepared in the present application has the chemical formula Pd / CsPbBr3, wherein the particle size of CsPbBr3 is 40-300nm, the size of palladium nanoparticle is 2-5nm, the visible light absorption range of palladium / perovskite material for visible light catalytic adjacent wood reaction can be extended to 532nm, photo-generated charge is generated by visible light excitation, and visible light catalytic suzuki reaction is carried out, to produce a series of biphenyl compounds connected with different substituents.The method of the present application is simple to operate, cost-saving, and mild reaction conditions, which has important significance in the field of visible light catalytic suzuki reaction technology.

This invention relates to the field of nanomaterials, and discloses a composite nanoparticle, its preparation method, and its application. The preparation method includes: mixing noble metal nanoparticles with an organic synthetic oil and then heating the mixture to react; wherein the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. The composite nanoparticle includes a core and a shell covering the core; the core is a noble metal nanoparticle, and the shell is carbon quantum dots; wherein the carbon quantum dots are carbonized products of the organic synthetic oil; and the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. This composite nanomaterial exhibits excellent stability and light absorption properties.

A kind of biphenyl compound shown in formula (I), its preparation method and application. It is also related to pharmaceutical compositions comprising the compound as active ingredient. The compound is a novel small molecule immunomodulator with excellent oral absorption characteristics, which can be used for treating and / or preventing a variety of diseases related to immunity.

This invention discloses a method for preparing biphenyl compounds from hawthorn leaves and their applications, belonging to the field of pharmaceutical technology. The biphenyl compounds from hawthorn leaves, as shown in the structural formula below, are obtained by separating the 70% ethanol extract from the dried leaves of hawthorn (Crataegus pinnatifida Bge.), a plant of the Rosaceae family, using various column chromatography and HPLC methods. DPPH free radical scavenging activity tests show that compounds 1 and 2 have good DPPH free radical scavenging activity, and their activity is stronger than that of the positive control drug VC. ABTS free radical scavenging activity tests show that compounds 1 and 2 have good ABTS free radical scavenging activity, and their activity is stronger than that of the positive control drug VC. Compounds 1 and 2 provided by this invention exhibit superior antioxidant activity; therefore, the biphenyl compounds described in this invention have the potential to be used in the preparation of clinical antioxidant drugs.

The application provides a liquid crystal oligomer, a liquid crystal phthalonitrile resin with intrinsic high thermal conductivity and a preparation method and application thereof. The liquid crystal oligomer is obtained by condensation polymerization of the following raw materials: diphenyl ether compounds, biphenyl compounds and nitro phthalonitrile; the raw material of the liquid crystal phthalonitrile resin of the application comprises the liquid crystal oligomer. The liquid crystal phthalonitrile of the application can be used in the fields of aerospace, military and national defense, rail transit, electronic appliances and the like, and is expected to make high-temperature-resistant and high-thermal-conductivity structural parts (such as aerospace vehicles) more lightweight, and can improve the heat dissipation capacity of equipment (such as radars, vehicle-mounted thermal control systems and integrated chips) and maintain the insulation properties, thereby prolonging the service life of the equipment.

The application relates to a negative electrode dispersant, a preparation method thereof and a lithium ion battery. The negative electrode dispersant comprises a cellulose polymer, the cellulose polymer comprises an alkaline cellulose compound and a crosslinking agent, the crosslinking agent comprises a biphenyl compound, the biphenyl compound comprises at least one biphenyl group, and further comprises one or more of an aldehyde group, an acyl group, an ester group and a carboxyl group. The scheme provided by the application can reduce the addition amount of CMC, improve the energy density of the battery, and does not affect the cycle performance and rate performance of the battery.

This invention discloses a method for the electro-oxidative synthesis of fluoroalkyl-substituted dibenzocycloheptanone compounds, relating to the field of organic synthesis technology. Specifically, it discloses an electrochemical reaction of an o-propynoyl biphenyl compound and a sodium fluoroalkyl sulfinate compound to obtain fluoroalkyl-substituted dibenzocycloheptanone compounds. Using an o-propynoyl biphenyl compound and a sodium fluoroalkyl sulfinate compound as raw materials, the two are subjected to a constant current electrochemical reaction in an electrolyte solution. Under specific reaction temperature and current conditions, the fluoroalkyl sulfinate anion is oxidized to a fluoroalkyl radical. This radical attacks the α-position of the carbonyl group of the ketene reactant to obtain an alkenyl radical. The alkenyl radical then undergoes 7-endo-trig cyclization to another benzene ring to construct a seven-membered ring. Finally, deprotonation yields the fluoroalkyl-substituted dibenzocycloheptanone compounds.

The invention discloses a preparation method and application of a series of cyclic molecular carbon. The core is efficient and accurate synthesis of a series of cyclic molecular carbon. Specifically, a benzyloxy selectively-substituted polyphenyl compound is designed, and a series of benzyloxy-substituted biphenyl aromatic hydrocarbon macrocycles are synthesized in a directional and high-yield manner by utilizing a Friedel-Crafts reaction; then, carrying out efficient removal of benzyl, a trifluoromethylsulfonyl esterification reaction and a Suzuki coupling reaction to obtain a series of conjugated extended biphenyl aromatic hydrocarbon macrocycles; further carrying out a demethylation reaction and a trifluoromethylsulfonyl esterification reaction to obtain a series of trifluoromethylsulfonyl ester substituted biphenyl aromatic hydrocarbon macrocycles; finally, through controllable intramolecular coupling reaction of the biphenyl aromatic hydrocarbon, the biphenyl aromatic hydrocarbon is efficiently converted into a series of cyclic molecular carbon. Functional studies find that the obtained cyclic molecular carbon shows very excellent recognition capability on footballene and is a novel footballene solubilizer, and the solubility of C60 and C70 in chloroform is improved by 15 times and 20 times respectively.

The invention discloses a biphenyl compound and application thereof. The invention provides a biphenyl compound as shown in a formula I or a formula II, a pharmaceutically acceptable salt of the biphenyl compound, a solvate of the biphenyl compound or a solvate of the pharmaceutically acceptable salt of the biphenyl compound. The biphenyl compound has an inhibition effect on PD-1 / PD-L1 binding, and can be used for treating or diagnosing related diseases such as tumors and the like.

The invention provides an isoxazole biphenyl compound with CBP BRD and BRD4 BD2 inhibitory activity as well as a preparation method and application of the isoxazole biphenyl compound, and also provides an isoxazole biphenyl compound with CBP BRD and BRD4 BD2 inhibitory activity or a pharmaceutically acceptable salt of the isoxazole biphenyl compound, and the isoxazole biphenyl compound has a structural formula shown as a general formula (I) and a general formula (II). The invention also provides application of the isoxazole biphenyl compound or the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the isoxazole biphenyl compound in preparation of drugs for preventing or treating cancers, inflammations and metabolic diseases related to CBP and BRD4. The invention has the following technical effects: a novel molecule is designed and synthesized, and the structure is optimized, so that a compound with specific inhibitory activity on two targets of CBP BRD and BRD4 BD2 at the same time is obtained. The invention further provides a synthesis method of the compound, and the target compound can be efficiently prepared.

The application provides a novel biphenyl compound and application thereof in preparation of a drug for treating pulmonary fibrosis, relates to the technical field of medicines, and the biphenyl compound is shown as general formula I. The compound can significantly improve BLM-induced pulmonary fibrosis in mice, and specific performance is as follows: reducing the range of pulmonary consolidation, repairing lung tissue structure, improving the survival rate of mice, reducing the lung coefficient, reducing pulmonary interstitial thickening, inflammatory cell infiltration and fibroblast focus formation, reducing abnormal deposition of collagen fibers in the pulmonary interstitium, and having a clear dose-effect relationship and good biological safety. The application provides a solid experimental basis for the application of the compound in preparation of the drug for treating pulmonary fibrosis, and has a wide application prospect.

Provided is a compound having excellent plant disease control efficacy. The compound represented by formula (A) can be used for controlling plant diseases.

The application belongs to the technical field of organic synthesis, and particularly relates to a Suzuki-Miyaura coupling reaction based on a low-loading palladium catalytic system and using di-tert-butyl phenyl phosphine as a key ligand, which can efficiently prepare substituted biphenyl compounds by using only 0.002% equivalent of palladium catalyst. The method uses 3,4-dichlorobenzene boronic acid and 2-chloro-4-fluoro nitrobenzene as reaction substrates, and uses the synergistic effect of palladium acetate as a transition metal catalyst, di-tert-butyl phenyl phosphine as a ligand and sodium hydroxide as a base to successfully realize Suzuki-Miyaura cross coupling in a green solvent water, and the target is converted into a structure diverse biphenyl compound. The application successfully develops a new process for one-pot synthesis of biphenyl compounds by precisely constructing a palladium catalytic system, which not only has the characteristics of mild reaction conditions and simple operation, but also shows significant technical advantages in economy, substrate universality and process expandability.

Antibiotic resistance leads to deadly hospital-acquired infections globally. The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have identified priority bacteria, including Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and particularly those carbapenem- resistant strains, also found in Enterobacterales (CRE) such as Escherichia coli and Klebsiella, as requiring new antibiotics. The present disclosure provides a chemical class of drugs less susceptible to existing mechanisms of antibiotic resistance and targeting difficult-to-treat bacterial infections. It more particularly provides compounds of formula (I), and compositions and uses thereof.

The invention discloses an Escherichia coli DH5alpha-A strain and a method for degrading polychlorinated biphenyl by using the Escherichia coli DH5alpha-A strain, and relates to application of the Escherichia coli strain DH5alpha-A with the preservation number of CCTCC (China Center For Type Culture Collection) NO: M20242004 in degradation of the polychlorinated biphenyl, in particular to application of the Escherichia coli strain DH5alpha-A in degradation of the polychlorinated biphenyl and application of the Escherichia coli strain DH5alpha-A in degradation of the polychlorinated biphenyl. The polychlorinated biphenyl is a biphenyl compound with the chlorine number larger than or equal to 3 and comprises 2, 2 ', 3, 3'-tetrachlorobiphenyl or trichlorobiphenyl; the method for degrading the polychlorinated biphenyl comprises the following steps: inoculating the Escherichia coli strain DH5 alpha-A in the claim 1 into a culture medium containing the polychlorinated biphenyl for culturing, and taking the polychlorinated biphenyl as a unique or main carbon source in the culture medium. In the invention, the Escherichia coli DH5 alpha-A is successfully separated and identified by directionally screening and enriching the polluted soil around a polychlorinated biphenyl production enterprise. Compared with the conventional Escherichia coli, the Escherichia coli has a remarkable difference in polychlorinated biphenyl degradation capability.

The invention discloses a preparation method of low-absorbance phenol-biphenylene phenolic resin, which comprises the following steps: mixing raw materials including phenol, biphenyl compounds and a cocatalyst, and introducing inert gas from the bottom of a reaction container to carry out condensation polymerization, thereby obtaining the low-absorbance phenol-biphenylene phenolic resin. According to the invention, the inert gas is forcibly filled in the reaction process to take away the micromolecular by-products, and the cocatalyst is combined to improve the reaction efficiency and selectivity, so that the purification step is simplified, the molecular weight distribution of the product is controllable, the production efficiency is improved, and the cost is reduced. The prepared phenol-biphenylene phenolic resin shows the characteristic of low absorbance, especially has high transparency at the wavelength of 400nm, and widens the application in the fields of optics, coatings and the like.

Disclosed in the present invention are a biphenyl compound, a method of preparation thereof, and an intermediate, a pharmaceutical composition and its uses. Specifically provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof. Said compound has good activity and selectivity at a γ retinoic acid receptor agonist, has virtually no agonistic activity at α and / or β retinoic acid receptors, and is thus beneficial for reducing systemic side effects.Preferably, the compound has a rather partial agonistic activity, has low skin irritation and few adverse reactions while maintaining its efficacy, and thus has good safety and compliance, such that the problems commonly present in existing RAR compounds are effectively resolved, and the compound can be used to treat and prevent diseases related to retinoic acid receptor γ.

To provide a method for producing a poly-substituted biphenyl compound in high regioselectivity without requiring complicated catalyst preparation.SOLUTION: The method for producing a poly-substituted biphenyl compound represented by general formula (2) includes a step of oxidatively dimerizing an aromatic compound represented by general formula (1) in the presence of a platinum compound and a copper compound.SELECTED DRAWING: None