50 results about "Biphenyl compound" patented technology

The invention provides a diketone biphenyl compound serving as a VAV1 degradation agent and application of the diketone biphenyl compound. Specifically provided are a compound represented by formula (I), a tautomer, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof. The compound provided by the invention is good in drug effect and can be used for preparing drugs for treating or preventing VAV1 related diseases.

A method for making the benzoate salt of 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]-2-fluoro-benzonitrile, designated compound (A), and methods for using compound (A) are provided.

The present application relates to a biphenyl compound, and a pharmaceutical composition thereof and the use thereof. Specifically, provided is a biphenyl compound as represented by formula (I), which can be used in the preparation of a drug, particularly in the preparation of a drug for preventing and / or treating diseases or conditions caused by or associated with the dysregulation of lymphocyte development or activity. Each group in formula (I) is as defined in the description.

Compounds of formula (I) capable of modulating store-operated calcium entry (SOCE) The present disclosure also relates to compositions and uses of compounds of formula (I) for treating disease conditions that depend on increased / decreased SOCE activity.

The present application relates to the technical field of oil and gas reservoir fracturing stimulation, discloses a phenolic resin biphenyl compound composition and application, an epoxy resin product and a preparation method thereof.The composition comprises a curing agent, a reinforcing agent and water; the curing agent is a bisphenol phenolic resin, the bisphenol phenolic resin comprises structural unit A shown in formula I and structural unit B shown in formula II; the reinforcing agent has a structure shown in formula III; the content of the structural unit A is 0-100 wt% and the content of the structural unit B is 0-100 wt% based on the total weight of the bisphenol phenolic resin.The composition comprises a crosslinked polymer and a reinforcing agent with a specific structure, which serves as a curing agent, and the prepared epoxy resin product has excellent high-temperature resistance and deformation resistance.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

The invention relates to the technical field of pesticides, in particular to a pentafluorosulfenyl-containing biphenyl compound, a composition and application of the pentafluorosulfenyl-containing biphenyl compound. The pentafluorosulfenyl-containing biphenyl compound is a compound as shown in a formula I, or a stereoisomer, a tautomer, an isotope derivative and a pesticide acceptable salt thereof. The biphenyl compound containing the pentafluorothio group shows an excellent prevention and control effect on various pests, particularly tetranychus cinnabarinus, tetranychus urticae, tetranychus shennieri, panonychus citri and the like, and compared with compounds disclosed in the prior art, the biphenyl compound containing the pentafluorothio group has better insecticidal or acaricidal activity and is safe to crops.

Provided is a compound having excellent plant disease control efficacy. The compound represented by formula (A) can be used for controlling plant diseases.

The invention belongs to the field of medicinal chemistry, and particularly relates to biphenyl compounds and application of the biphenyl compounds in preparation of compounds similar to colopivir. According to the synthesis route of the colopivir, the biphenyl intermediate compound is utilized, and the colopivir is prepared with high yield from cheap and easily available starting materials by adopting a simple reaction type and a cheap conventional reagent. As a one-pot synthesis strategy is adopted twice in the route, the synthesis efficiency and the operation convenience are greatly improved, the time, material and labor costs are reduced, and the method has a wide commercial development prospect.

The invention discloses a biphenyl-diketopiperazine indole alkaloid hybrid compound, which is separated from a fermentation product of a strain Aspergillus candidus HNNU0546, and has a skeleton molecule formed by hybridizing rare diketopiperazine indole alkaloid with biphenyl molecules through an isopentenylation branch chain, and the biphenyl compound can obviously inhibit the activity of crop disease fungi.

The invention discloses a modified sulfonated polyether-ether-ketone proton exchange membrane as well as a preparation method and application thereof. The modified sulfonated polyetheretherketone proton exchange membrane comprises sulfonated polyetheretherketone with the sulfonation degree of 85-90% and a triazine biphenyl compound with an isocyanate group. The mass ratio of the sulfonated polyether ether ketone to the triazine biphenyl compound with the isocyanate group is 100: (5-10). According to the proton exchange membrane, sulfonated polyether-ether-ketone is modified through a triazine biphenyl compound with an isocyanate group, under the condition that good proton conductivity is kept, the mechanical strength and dimensional stability of the high-sulfonation-degree polyether-ether-ketone proton exchange membrane can be effectively improved, the vanadium ion permeability is reduced, and the proton exchange membrane has good comprehensive use performance. The diaphragm can be used for a hydrogen fuel cell or a hydrogen production electrolytic cell.

The invention discloses a biphenyl compound as shown in a formula (I), and a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound is a novel small molecule immunomodulator having an excellent oral absorbable characteristic, and can be used for treating and / or preventing various diseases related to immunity.

The present application relates to the technical field of separation and purification of Schizonepeta tenuifolia Briq, and relates to a biphenyl compound in Schizonepeta tenuifolia Briq, a preparation method thereof and application of the biphenyl compound as an anti-inflammatory drug. The biphenyl compound in Schizonepeta tenuifolia Briq is obtained by the following steps: soaking Schizonepeta tenuifolia Briq, heating and reflux extraction, recovering and concentrating under reduced pressure, obtaining total extract of Schizonepeta tenuifolia Briq, extracting and concentrating with petroleum ether, dichloromethane and ethyl acetate, obtaining a dichloromethane part extract, gradient elution separation of the dichloromethane part extract, gradient elution separation of the fourth fraction of the obtained eight fractions, gradient elution separation of the third fraction of the obtained six fractions, gradient elution separation of the fifth fraction of the obtained eight fractions, purification and separation of the eluate, and collection of the eluate, and the biphenyl compound in Schizonepeta tenuifolia Briq is obtained at 16.4 minutes. The present application discloses the biphenyl compound in Schizonepeta tenuifolia Briq for the first time, and in vitro anti-inflammatory pharmacodynamic experiments are carried out, which prove that the biphenyl compound has a certain inhibitory effect on RAW264.7 cells and can be applied to preparation of anti-inflammatory drugs.

The present disclosure also relates to a pharmaceutical composition that comprises the compound as an active ingredient.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for catalytically synthesizing a dibenzo [b, d] azepine compound by using an N-heterocyclic carbene oxazoline cyclic palladium compound. The invention aims to provide a novel synthesis method of a dibenzo [b, d] azepine compound, and particularly relates to a method for synthesizing the dibenzo [b, d] azepine compound by using a high-catalytic-activity N-heterocyclic carbene oxazoline cyclic palladium compound as a catalyst through a carbon-nitrogen / carbon-carbon bond cascade reaction. The 2, 2 '-dihalogenated biphenyl compound and an N-alkyl substituted allylamine compound are directly synthesized into the dibenzo [b, d] azepine compound in one step. The catalyst used in the invention has high catalytic activity, and the reaction has good compatibility of products and functional groups; the catalyst is easy to synthesize, and the raw materials of the 2, 2 '-dihalogenated biphenyl compound used in the synthesis route are cheap and easy to obtain.

Disclosed herein is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also disclosed herein is a pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive. Further disclosed herein is a method for preventing or treating a disease or condition through the modulation of the glucagon receptor using a compound of formula (I), or a pharmaceutically acceptable salt thereof.

A novel disulfide biphenol ether compound and its preparation method and application for treating inflammatory skin diseases, the structural formula of the disulfide biphenol ether compound is: biphenyl diester is first dissolved in anhydrous tetrahydrofuran solvent, lithium aluminum hydroxide is added, quenched, filtered, extracted with dichloromethane, water is added to quench the reaction, extracted with dichloromethane, the organic phases are combined, after removing residual moisture, the reduced pressure rotary evaporation and recrystallization are removed to obtain intermediate 2; intermediate 2 and potassium thioacetate are added to solvent N, N-dimethylformamide and extracted, the organic phases are combined, and the solvent is evaporated and concentrated to obtain a light intermediate 3; intermediate 3 is dissolved in anhydrous methanol, sodium methoxide is added, stirred, extracted with ethyl acetate, and the organic phases are combined to obtain. The disulfide biphenyl compound prepared by the present invention has good anti-inflammatory ability, can effectively reduce inflammatory infiltration in tissue, improve the inflammatory phenotype of animal models, and can prevent and treat inflammatory skin diseases.

Disclosed in the present invention are a biphenyl compound and the use thereof. The present invention provides a biphenyl compound represented by formula I or formula II, a pharmaceutically acceptable salt and solvate thereof or a solvate of the pharmaceutically acceptable salt thereof. The biphenyl compound has an inhibitory effect on PD-1 / PD-L1 binding, and thus can be used for treating or diagnosing related diseases such as tumors.

This invention discloses a synthetic method for Cochlearol B, belonging to the field of natural product technology. The method uses commercially available 2-bromo-3-methoxy-4-hydroxyacetophenone and 2,5-dihydroxyphenylboronic acid as raw materials. After protection with tert-butyldimethylchlorosilane, Wittig olefination, and Suzuki cross-coupling, a biphenyl compound is obtained. Following a Wacker-type cross-coupling tandem reaction, the substrate is protected with methoxymethylene bromide, and the tert-butyldimethylsilyl group is removed with a fluorine reagent. Then, under high-valent iodine reagent conditions, phenol is dearomatized in the next step. After reduction, a [2+2] cycloaddition reaction occurs under light to obtain a highly substituted cyclobutane product. Finally, through reduction, Wittig olefination, epoxidation, and epoxide ring-opening rearrangement, the chemical synthesis of Cochlearol B can be achieved. This synthetic route has the advantages of being simple, efficient, easy to operate, and low-cost, making it suitable for the large-scale synthesis of Cochlearol B and providing an important material basis for the evaluation of the bioactivity of the natural product Cochlearol B.

Provided are a diketone biphenyl compound as a VAV1 degradation agent, and a use thereof. Specifically, provided are a compound represented by formula (I), and a tautomer, stereoisomer, pharmaceutically acceptable salt or prodrug thereof. The provided compound has good efficacy, and can be used for preparing a drug for treating or preventing VAV1-related diseases.

The invention provides a catalyst and a preparation method thereof, and a preparation method of a biphenyl compound. The catalyst comprises a carrier, the carrier comprises a modified molecular sieve, and the modified molecular sieve is obtained by modifying a molecular sieve through alkali metal salt; and, an active ingredient, the active ingredient comprising a noble metal cluster; wherein the active component is loaded on the surface and / or inside the modified molecular sieve; in addition, at least part of noble metal clusters are encapsulated in pore channels of the modified molecular sieve. The catalyst can be used for preparing biphenyl compounds. The preparation method of the catalyst is simple and easy to implement, raw materials are easy to obtain, and the catalyst is suitable for mass production.

This invention relates to the field of organic heat transfer fluid technology, providing a biphenyl-based semi-synthetic organic heat transfer fluid, its preparation method, and its applications. The biphenyl-based semi-synthetic organic heat transfer fluid comprises a biphenyl compound, polyethylbenzene, and an alkylnaphthalene, wherein the alkylnaphthalene includes ethylnaphthalene and / or propylnaphthalene; the content of polyethylbenzene in the biphenyl-based semi-synthetic organic heat transfer fluid is 20wt%–35wt%; the mass ratio of the biphenyl compound to the alkylnaphthalene is 1:(0.05–1). The biphenyl-based semi-synthetic organic heat transfer fluid provided by this invention has a simple composition, requires no functional additives, effectively reduces costs and the difficulty of controlling the product preparation process, and possesses a high auto-ignition point and closed-cup flash point, thus exhibiting better thermal stability. This ensures that all performance indicators fully meet the performance requirements of the L-QC320 type product in GB23971-2009, giving it strong market competitiveness.

The present application relates to a kind of visible light catalytic adjacent wood reaction palladium / perovskite material and preparation method and application.The present application belongs to the cross field of inorganic chemistry, organic chemistry, material chemistry.The palladium / perovskite material prepared in the present application has the chemical formula Pd / CsPbBr3, wherein the particle size of CsPbBr3 is 40-300nm, the size of palladium nanoparticle is 2-5nm, the visible light absorption range of palladium / perovskite material for visible light catalytic adjacent wood reaction can be extended to 532nm, photo-generated charge is generated by visible light excitation, and visible light catalytic suzuki reaction is carried out, to produce a series of biphenyl compounds connected with different substituents.The method of the present application is simple to operate, cost-saving, and mild reaction conditions, which has important significance in the field of visible light catalytic suzuki reaction technology.

The invention provides a 1, 2, 4-oxadiazole biphenyl compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a 1, 2, 4-oxadiazole biphenyl compound which has a structure as shown in a formula h. By introducing dioxin, amide bridges and chlorine atoms, the water solubility of the compound can be improved. In addition, potassium trimethylsilanolate is used as an alkali reagent of an SZUKI coupling reaction, methylbenzene is used for replacing trichloroacetic anhydride to serve as a solvent of a cyclization reaction, and a mixed solvent of dichloromethane and methanol is used as a reaction solvent of reductive amination to optimize the reaction. When the 1, 2, 4-oxadiazole biphenyl compound provided by the invention is used as a PD-L1 small-molecule inhibitor, the 1, 2, 4-oxadiazole biphenyl compound has good targeting property and anti-proliferative activity, and a basis is provided for further enriching a small-molecule inhibitor compound library and researching the structure-function relationship of the 1, 2, 4-oxadiazole inhibitor.

This invention relates to the field of nanomaterials, and discloses a composite nanoparticle, its preparation method, and its application. The preparation method includes: mixing noble metal nanoparticles with an organic synthetic oil and then heating the mixture to react; wherein the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. The composite nanoparticle includes a core and a shell covering the core; the core is a noble metal nanoparticle, and the shell is carbon quantum dots; wherein the carbon quantum dots are carbonized products of the organic synthetic oil; and the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. This composite nanomaterial exhibits excellent stability and light absorption properties.

A kind of biphenyl compound shown in formula (I), its preparation method and application. It is also related to pharmaceutical compositions comprising the compound as active ingredient. The compound is a novel small molecule immunomodulator with excellent oral absorption characteristics, which can be used for treating and / or preventing a variety of diseases related to immunity.

This invention discloses a method for preparing biphenyl compounds from hawthorn leaves and their applications, belonging to the field of pharmaceutical technology. The biphenyl compounds from hawthorn leaves, as shown in the structural formula below, are obtained by separating the 70% ethanol extract from the dried leaves of hawthorn (Crataegus pinnatifida Bge.), a plant of the Rosaceae family, using various column chromatography and HPLC methods. DPPH free radical scavenging activity tests show that compounds 1 and 2 have good DPPH free radical scavenging activity, and their activity is stronger than that of the positive control drug VC. ABTS free radical scavenging activity tests show that compounds 1 and 2 have good ABTS free radical scavenging activity, and their activity is stronger than that of the positive control drug VC. Compounds 1 and 2 provided by this invention exhibit superior antioxidant activity; therefore, the biphenyl compounds described in this invention have the potential to be used in the preparation of clinical antioxidant drugs.

The application provides a liquid crystal oligomer, a liquid crystal phthalonitrile resin with intrinsic high thermal conductivity and a preparation method and application thereof. The liquid crystal oligomer is obtained by condensation polymerization of the following raw materials: diphenyl ether compounds, biphenyl compounds and nitro phthalonitrile; the raw material of the liquid crystal phthalonitrile resin of the application comprises the liquid crystal oligomer. The liquid crystal phthalonitrile of the application can be used in the fields of aerospace, military and national defense, rail transit, electronic appliances and the like, and is expected to make high-temperature-resistant and high-thermal-conductivity structural parts (such as aerospace vehicles) more lightweight, and can improve the heat dissipation capacity of equipment (such as radars, vehicle-mounted thermal control systems and integrated chips) and maintain the insulation properties, thereby prolonging the service life of the equipment.

To provide novel compounds able to modulate Store Operated Calcium Entry (SOCE).SOLUTION: Provided is a compound of formula (I). Also provided are compositions and uses of compounds of formula (I) for treatment of disease condition depending on increased / decreased activity of SOCE.SELECTED DRAWING: None

The application relates to a negative electrode dispersant, a preparation method thereof and a lithium ion battery. The negative electrode dispersant comprises a cellulose polymer, the cellulose polymer comprises an alkaline cellulose compound and a crosslinking agent, the crosslinking agent comprises a biphenyl compound, the biphenyl compound comprises at least one biphenyl group, and further comprises one or more of an aldehyde group, an acyl group, an ester group and a carboxyl group. The scheme provided by the application can reduce the addition amount of CMC, improve the energy density of the battery, and does not affect the cycle performance and rate performance of the battery.