The invention relates to a preparation method of Cs5SiFe (OH2) W11O39. 6H2O sustained and
controlled release capsules. The preparation method comprises the following steps of by taking Cs5SiFe (OH2) W11O39. 6H2O as a
raw material and
lactose, ethylcellulose, hydroxypropyl methylcellulose,
silicon dioxide,
montmorillonite,
sodium chloride,
cellulose acetate,
dibutyl phthalate, dimethicone,
magnesium stearate,
sodium bisulfite and lauryl
sodium sulfate as auxiliary materials, respectively preparing sustained-release
pellets, performing wrapping with an adsorption
water diversion layer, performing wrapping with a controlled-release
coating layer, and finally, performing
capsule filling to obtain the controlled-release capsules. According to the invention, in-vitro release is uniform, the
controlled release effect can be achieved, the average release rate per 2 hours in an in-vitro release rate test is 10-15%, compared with a traditional
controlled release preparation, the sustained and controlled release capsules are more uniform in release, the constant-speed
release time is nearly 14 hours, the
shelf life of the sustained and controlled release capsules is long and can reach 24 months, the
impurity increment in the placing process is small, and the
impurity increment is only 0.13% after the sustained and controlled release capsules are placed for 24 months. The sustained and controlled release capsules are high in anti-tumor activity, low in
toxicity and low in price, and can be used for treating human hepatoma
carcinoma cells (HepG-2),
human lung cancer cells (A549), humanbreast
cancer cells (MCF-7) and
human colon cancer cells (CT26 and HT29).