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Preparation method and application of Cs5SiFe (OH2) W11O39. 6H2O sustained and controlled release capsules

A technology of capsules and sustained-release pellets, which is applied in the field of medicine, can solve the problems that anti-tumor drugs have not been reported, and there is no Keggin-type silicotungstate anti-tumor preparation, etc., and achieve small fluctuations in blood drug concentration, low price, and safety sex high effect

Active Publication Date: 2020-11-10
JINLIN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And Keggin type silicotungstate M 5 [SiFe(H 2 O)W 11 o 39 ]·nH 2 O has been reported as a catalyst for catalyzing alcohol oxidation reactions, but its application as an antitumor drug has not been reported, and there is no Keggin type silicotungstate antitumor preparation on the market

Method used

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  • Preparation method and application of Cs5SiFe (OH2) W11O39. 6H2O sustained and controlled release capsules
  • Preparation method and application of Cs5SiFe (OH2) W11O39. 6H2O sustained and controlled release capsules
  • Preparation method and application of Cs5SiFe (OH2) W11O39. 6H2O sustained and controlled release capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a Cs 5 SiFe(OH 2 )W 11 o 39 ·6H 2 The preparation method of O sustained and controlled-release capsules is prepared in the following steps:

[0023] 1.K 8 SiW 11 o 39 13H 2 Preparation of O:

[0024] (1) Weigh 1.1 kg (5 mol) of sodium metasilicate and place it in a beaker, add 10 L of distilled water, stir and dissolve to obtain solution A;

[0025] (2) Add 1.82kg sodium tungstate (55mol) into 30L boiled distilled water, stir and dissolve to obtain solution B, then add 16.5L hydrochloric acid (4mol / L) to solution B within 30min, stir to dissolve, and then add the solution A, and quickly add 5L hydrochloric acid (4mol / L) to make the solution pH value 5.8, continue to stir and keep the solution boiling for 1 hour, then cool to room temperature, filter, then add 15kg potassium chloride, then continue to stir until white precipitate is generated , filter, collect the white precipitate, then wash the white precipitate with 5L saturated potassium chloride solution, ...

Embodiment 2

[0044] a Cs 5 SiFe(OH 2 )W 11 o 39 ·6H 2 The preparation method of O sustained and controlled-release capsules is prepared in the following steps:

[0045] 1. The preparation of slow-release pellets: get the Cs that 30g embodiment 1 makes 5 SiFe(OH 2 )W 11 o 39 ·6H 2 O, 80g lactose, 30g ethyl cellulose, 20g hypromellose, and 20g silicon dioxide were respectively pulverized through a 100-mesh sieve, then placed in a three-dimensional motion mixer, mixed for 18 minutes to obtain a mixed powder, and set aside; take another volume 2000g of ethanol solution with a fraction of 65%, slowly add the above mixed powder under stirring condition, continue to stir for 60 minutes to disperse completely, and obtain the mixed powder dispersion liquid for later use; put the above mixed powder dispersion liquid in spray drying Spray granulation is carried out in the machine, the air inlet temperature is set at 100-110°C, the rotation speed of the peristaltic pump is 2.0-3.5r / min, and t...

Embodiment 3

[0050] a Cs 5 SiFe(OH 2 )W 11 o 39 ·6H 2 The preparation method of O sustained and controlled-release capsules is prepared in the following steps:

[0051] 1. The preparation of slow-release pellets: get the Cs that 60g embodiment 1 makes 5 SiFe(OH 2 )W 11 o 39 ·6H 2 O, 130g lactose, 70g ethylcellulose, 50g hypromellose, and 40g silicon dioxide were pulverized through a 100-mesh sieve respectively, then placed in a three-dimensional motion mixer, mixed for 22 minutes to obtain a mixed powder, and set aside; take another volume 3000g of ethanol solution with a fraction of 65%, slowly add the above mixed powder under stirring condition, continue to stir for 80 minutes to disperse completely, and obtain the mixed powder dispersion liquid for later use; put the above mixed powder dispersion liquid in spray drying Spray granulation is carried out in the machine, the air inlet temperature is set at 100-110°C, the rotation speed of the peristaltic pump is 2.0-3.5r / min, and t...

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Abstract

The invention relates to a preparation method of Cs5SiFe (OH2) W11O39. 6H2O sustained and controlled release capsules. The preparation method comprises the following steps of by taking Cs5SiFe (OH2) W11O39. 6H2O as a raw material and lactose, ethylcellulose, hydroxypropyl methylcellulose, silicon dioxide, montmorillonite, sodium chloride, cellulose acetate, dibutyl phthalate, dimethicone, magnesium stearate, sodium bisulfite and lauryl sodium sulfate as auxiliary materials, respectively preparing sustained-release pellets, performing wrapping with an adsorption water diversion layer, performing wrapping with a controlled-release coating layer, and finally, performing capsule filling to obtain the controlled-release capsules. According to the invention, in-vitro release is uniform, the controlled release effect can be achieved, the average release rate per 2 hours in an in-vitro release rate test is 10-15%, compared with a traditional controlled release preparation, the sustained and controlled release capsules are more uniform in release, the constant-speed release time is nearly 14 hours, the shelf life of the sustained and controlled release capsules is long and can reach 24 months, the impurity increment in the placing process is small, and the impurity increment is only 0.13% after the sustained and controlled release capsules are placed for 24 months. The sustained and controlled release capsules are high in anti-tumor activity, low in toxicity and low in price, and can be used for treating human hepatoma carcinoma cells (HepG-2), human lung cancer cells (A549), humanbreast cancer cells (MCF-7) and human colon cancer cells (CT26 and HT29).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Cs 5 SiFe(OH 2 )W 11 o 39 ·6H 2 The preparation method and application of O sustained and controlled release capsule. Background technique [0002] Malignant tumor is what people call cancer, which is a general term for more than 100 related diseases. When a cell in the body mutates, it divides continuously without the body's control, eventually forming cancer. All organs in the human body are composed of cells. Cells grow and differentiate to meet the body's needs, an orderly process that keeps people healthy. However, if the cells continue to divide, these extra large numbers of cells form a tumor. Cells of malignant tumors can invade and destroy adjacent tissues and organs. Moreover, cancer cells can pass out of the tumor and enter the blood or lymphatic system. This is how cancer forms new tumors from the original site to other organs. This process is called cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/62A61K47/38A61K47/26A61K47/02A61K47/20A61K33/24A61P35/00
CPCA61K9/501A61K9/5015A61K9/5042A61K9/5073A61K33/24A61P35/00
Inventor 薛莹雪于泓韩丽琴
Owner JINLIN MEDICAL COLLEGE
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