Preparation method and application of keggin type silicotungstate sustained-release capsules

A technology of silicotungstic acid salt and capsule, which is applied in the field of medicine and achieves the effects of small impurity increment, reduced toxic and side effects, and low price.

Active Publication Date: 2021-03-16
JINLIN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Keggin type silicotungstate M 5 [SiFe(H 2 O)W 11 o 39 ]·nH 2 O(M=K,Rb,Cs) has been reported as an effective catalyst for the oxidation of alcohols, but its application as an antitumor drug has not been reported, and there is no Keggin type silicotungstate anticancer drug on the market. tumor preparation

Method used

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  • Preparation method and application of keggin type silicotungstate sustained-release capsules
  • Preparation method and application of keggin type silicotungstate sustained-release capsules
  • Preparation method and application of keggin type silicotungstate sustained-release capsules

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A preparation method of anti-cancer Keggin type silicotungstate sustained-release capsules, prepared according to the following steps:

[0028] 1.K 8 SiW 11 o 39 13H 2 Preparation of O:

[0029] (1) Weigh 1.1 kg (5 mol) of sodium metasilicate and place it in a beaker, add 10 L of distilled water, stir and dissolve to obtain solution A;

[0030] (2) Add 1.82kg sodium tungstate (55mol) into 30L boiled distilled water, stir and dissolve to obtain solution B, then add 16.5L hydrochloric acid (4mol / L) to solution B within 30min, stir to dissolve, and then add the solution A, and quickly add 5L hydrochloric acid (4mol / L) to make the solution pH value 5.0~6.0, continue to stir and keep the solution boiling for 1 hour, then cool to room temperature, filter, then add 15kg potassium chloride, and then continue to stir until White precipitate, filter, collect the white precipitate, then wash the white precipitate with 5L saturated potassium chloride solution, wash twice, wash...

Embodiment 2

[0049] A preparation method of anti-cancer Keggin type silicotungstate sustained-release capsules, prepared according to the following steps:

[0050] 1. Rb 5 SiFe(OH 2 )W 11 o 39 ·7H 2 O(RbSiW 11 Fe) Preparation:

[0051] Prepare K by the preparation method of Example 1 5 SiFe(OH 2 )W 11 o 39 14H 2 O, then K 5 SiFe(OH 2 )W 11 o 39 14H 2 Dissolve O in distilled water. After the dissolution is complete, cool to 2°C, and then pass this solution through H at a temperature of 2±0.5°C. + Type ion exchange resin was exchanged twice. Weigh an appropriate amount of Rb 2 CO 3 , dissolved in ice water, then slowly added to the exchanged acid solution, stirred for 30 minutes, then added an equal volume of 1:3 (v / v) ice methanol-ethanol mixed solution to produce a yellow precipitate, suction filtered, and the product Recrystallize in water at 80°C to achieve the purpose of purifying the product. Collect the precipitate and dry at room temperature to obtain the target p...

Embodiment 3

[0059] A preparation method of anti-cancer Keggin type silicotungstate sustained-release capsules, prepared according to the following steps:

[0060] 1. The preparation of slow-release pellets: get the Rb that embodiment 2 makes 5 SiFe(OH 2 )W 11 o 39 ·7H 2 O80g, lactose 100g, ethyl cellulose 20g, hypromellose 30g, silicon dioxide 10g, then take the above materials and pulverize them through a 100-mesh sieve respectively, mix them and put them in a three-dimensional motion mixer, and mix them for 10 minutes to get a mixed powder , for subsequent use; take another 2000 g of ethanol solution with a volume fraction of 60%, slowly add the above-mentioned mixed powder under stirring conditions, continue to stir for 60 minutes to completely disperse, and obtain a mixed powder dispersion, for subsequent use; the above-mentioned mixed powder The dispersion liquid is placed in a spray dryer for spray granulation, set the inlet air temperature at 100°C, the peristaltic pump speed a...

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Abstract

A preparation method of an anticancer Keggin type silicotungstate sustained / controlled-release capsule comprises preparation of sustained-release pellets, coating of an adsorption water leading layer,coating of a controlled-release coating layer and final capsule filling to prepare the anticancer Keggin type silicotungstate sustained / controlled-release capsule, wherein the sustained-release pellets consist of Keggin type silicotungstate, lactose, ethyl cellulose, hydroxypropyl methylcellulose and silicon dioxide; and the adsorption water leading layer consists of an adsorbent and a hydrophilic agent. The anticancer Keggin type silicotungstate sustained / controlled-release capsule is uniformly released in vitro, the average release rate every 2 hours in an in-vitro release rate test of thecapsule is 10%-15%, the capsule is released more uniformly than a conventional controlled / sustained-release preparation and can be released at a constant speed for about 16 hours, and the shelf life of the product is as long as 24 months. The Keggin type silicotungstate sustained / controlled-release capsule is high in antitumor activity, low in toxicity, low in price, wide in antitumor cell range and applicable to treatment of human hepatoma cells (HepG-2), human lung cancer cells (A549), human breast cancer cells (MCF-7) and human colon cancer cells (CT26 and HT29).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method and application of an anti-cancer Keggin type silicotungstate slow-controlled release capsule. Background technique [0002] As one of the diseases with the highest mortality rate in human beings, cancer poses a great threat to human health and life. Its main feature is the uncontrollable growth and spread of abnormal cells. At present, the survival rate of cancer is generally low. One of the main reasons is that the early diagnosis of cancer patients is not timely, which further deteriorates the condition and misses the best opportunity for treatment; secondly, the lack of reliable and effective treatment methods prevents cancer from be effectively eradicated. Drug therapy plays an important role in the treatment of malignant tumors. Although the existing anti-tumor drugs can cure some tumors and have a certain effect on most tumors, they have problems su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K33/26A61K47/02A61K47/38A61P35/00
CPCA61K9/501A61K9/5042A61K9/5073A61K9/5089A61K33/26A61P35/00
Inventor 薛莹雪于泓崔桂花李文亮韩丽琴
Owner JINLIN MEDICAL COLLEGE
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