Nifedipine micro-porous osmotic pump particle and preparation method thereof

A nifedipine and osmotic pump technology, applied in the field of medicine, can solve the problem that the sustained release time can only reach more than 6 hours, and achieve the effects of avoiding the fluctuation of blood drug concentration, reducing the number of times of taking the medicine, and improving the correlation between the body and the body.

Inactive Publication Date: 2018-03-09
QINGDAO HUANGHAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sustained release time can only reach more than 6 hours

Method used

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  • Nifedipine micro-porous osmotic pump particle and preparation method thereof
  • Nifedipine micro-porous osmotic pump particle and preparation method thereof
  • Nifedipine micro-porous osmotic pump particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] prescription

[0034]

[0035] Preparation Process:

[0036] 1. Preparation of pills containing:

[0037] Screen 300g of polyoxyethylene coagulant particles with a particle size of 150~250μm, and place them in a DPP-II fluidized bed granulating and coating machine; weigh the prescribed amount of nifedipine, hypromellose E5, sodium chloride, and lactose , Dispersed in 95% ethanol, evenly dispersed. Turn on the fluidized bed blast volume 15±2 (m 3 / h) / kg, atomizing pressure 1.5±0.2bar, spraying speed 15±1g / min, inlet air temperature 50±2℃, material temperature 30±2℃, after spraying, continue drying in the fluidized bed , Get nifedipine-containing pills.

[0038] 2. Semi-permeable membrane coating

[0039] Weigh the prescribed amount of cellulose acetate, polyethylene glycol 4000, and hypromellose E5 and dissolve them in acetone-water solution. After the dissolution is complete, place the above-mentioned nifedipine-containing pills in the DPP-II fluidized bed granulation package ...

Embodiment 2

[0043] prescription

[0044]

[0045] Preparation Process:

[0046] 1. Preparation of pills containing:

[0047] Screen 300g of polyoxyethylene 303 particles with a particle size of 150-250μm, and place them in a DPP-II fluidized bed granulating and coating machine; weigh the prescription amount of nifedipine, hydroxypropyl cellulose LF, potassium chloride, and mannitol , Dispersed in 95% ethanol, evenly dispersed. Turn on the fluidized bed blast volume 15±2 (m 3 / h) / kg, atomizing pressure 1.5±0.2bar, spraying speed 14±1g / min, inlet air temperature 50±2℃, material temperature 30±2℃, after spraying, continue drying in fluidized bed , Get nifedipine-containing pills.

[0048] 2. Semi-permeable membrane coating

[0049] Weigh the prescribed amount of cellulose acetate, triethyl citrate, and hydroxypropyl cellulose LF and dissolve them in an acetone-water solution. After the dissolution is complete, place the nifedipine-containing pills in the DPP-II fluidized bed granulation bag In the...

Embodiment 3

[0053] prescription

[0054]

[0055] Preparation Process:

[0056] 1. Preparation of pills containing:

[0057] Screen 300g of polyoxyethylene 303 particles with a particle size of 150-250μm, and place them in a DPP-II fluidized bed granulating and coating machine; weigh the prescription amount of nifedipine, hypromellose E5, sodium chloride, and lactose, Disperse in 95% ethanol, evenly dispersed. Turn on the fluidized bed blast volume 16±2(m 3 / h) / kg, atomizing pressure 1.6±0.2bar, spraying speed 18±1g / min, inlet air temperature 50±2℃, material temperature 30±2℃, after spraying, continue drying in the fluidized bed , Get nifedipine-containing pills.

[0058] 2. Semi-permeable membrane coating

[0059] Weigh the prescription amount of ethyl cellulose, polyethylene glycol, and hypromellose E5 and dissolve it in acetone-water solution. After the dissolution is completed, place the nifedipine-containing pills in the DPP-II fluidized bed granulation bag In the clothes machine, spray th...

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Abstract

The invention belongs to the technical field of medicines and in particular discloses a nifedipine micro-porous osmotic pump particle taking polyoxyethylene-containing particles as an expanded pill core and a preparation method thereof. The micro-porous osmotic pump particle takes the polyoxyethylene particles as the expanded pill core. The nifedipine micro-porous osmotic pump particle prepared bythe invention is capable of releasing drugs at a nearly zero release rate and is simple in production process and capable of easily realizing industrialized enlargement.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to nifedipine microporous osmotic pump particles containing polyoxyethylene particles as expanded pellet cores and a preparation method thereof. Background technique [0002] Nifedipine (Nifedipine), chemical name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester, calcium One of the ion antagonists is the drug of choice for variant angina pectoris. It is clinically suitable for the prevention and treatment of coronary heart disease angina pectoris, suitable for various types of hypertension, and has a good effect on refractory and severe hypertension. [0003] Hypertension is one of the most common cardiovascular diseases in the world today, and it is also a major risk factor for cardiovascular and cerebrovascular diseases. The prevalence of hypertension in my country is about 12%. The number of hypertensive patients currently exceeds 100...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K9/22A61K31/4422A61K47/10A61K47/38A61P9/12
CPCA61K9/2081A61K9/5078A61K31/4422A61K47/10A61K47/38
Inventor 李普成赵月芳丁姣姣胡关容解雨婷朗悦王美闫忠辉
Owner QINGDAO HUANGHAI PHARM CO LTD
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