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Intelligent numerical control bionic drug dissolubility tester

Dissolution and measuring instrument technology, applied in the field of intelligent numerical control biomimetic drug dissolution measuring instrument, can solve the problem that the drug dissolution rate cannot be well predicted, the drug dissolution instrument cannot well simulate peristalsis and the process of digestion and absorption, and the drug dissolution rate Poor correlation, etc.

Inactive Publication Date: 2012-01-11
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this kind of drug dissolution apparatus cannot well simulate the peristalsis and digestion and absorption process of the gastrointestinal tract in the human body, so that the in vivo and in vitro correlation of the detected drug dissolution rate is relatively poor, and the drug dissolution in vivo cannot be well predicted. , leading to errors in the test results of drug dissolution in vitro, which cannot truly reflect the absorption and utilization of drugs in the body

Method used

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  • Intelligent numerical control bionic drug dissolubility tester
  • Intelligent numerical control bionic drug dissolubility tester
  • Intelligent numerical control bionic drug dissolubility tester

Examples

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Embodiment 1

[0044] Embodiment 1 of the intelligent numerical control bionic drug dissolution tester of the present invention is as follows: Figure 1 to Figure 5As shown, it includes a gastrointestinal bionic device 1, a sampling tank 2 and a controller 3. The gastrointestinal bionic device 1 is provided with a sampling port and a sampling port, and the sampling tank 2 is provided with a through hole 23, which passes through the first The silicone tube 4 is in communication with the sampling port, and the sampling port is in communication with the second silicone tube 5; the gastrointestinal bionic device 1 includes a bionic stomach 11, a bionic intestinal tract 12 communicated with the bionic stomach 11, a peristaltic pump 13 and an extrusion gear 14, The peristaltic pump 13 and the extruding gear 14 are in conflict with the outer surface of the bionic stomach 11 and the outer surface of the bionic intestinal tract 12. The transmission shaft of the peristaltic pump 13 and the transmission...

Embodiment 2

[0087] Embodiment 2 of the intelligent numerical control bionic drug dissolution tester of the present invention is as follows: Figure 6 to Figure 8 As shown, the main technical solution of this embodiment is the same as that of Embodiment 1, the difference is that the peristaltic pump 13 includes a transmission shaft 135, a gear fixing plate 134, a first gear 131 connected to the gear fixing plate 134, a second gear 132, the third gear 133, the transmission shaft 135 is connected with the DC motor, the transmission shaft 135 is covered with a transmission gear 136, and the transmission gear 136 meshes with the first gear 131, the second gear 132, and the third gear 133 respectively, and the first gear 131 , The axes of the second gear 132 and the third gear 133 are arranged in an equilateral triangle.

[0088] Preferably, the number of teeth of the extrusion gear 14 , the first gear 131 , the second gear 132 and the third gear 133 is set to 40-50.

[0089] Preferably, the cre...

Embodiment 3

[0091] Embodiment 3 of the intelligent numerical control bionic drug dissolution tester of the present invention is as follows: figure 1 As shown, the main technical solution of this embodiment is the same as that of Embodiment 2, the difference is that the intelligent numerical control bionic drug dissolution tester also includes a waste liquid treatment device 9, the waste liquid input end of the waste liquid treatment device and the bionic intestine The liquid medicine output end of channel 12 is connected. Since the medicinal liquid contains various chemical substances, direct discharge will pollute the environment. Therefore, using the waste liquid treatment device 9 to process the medicinal liquid discharged from the medicinal liquid output end of the bionic intestine has the advantage of environmental protection.

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Abstract

Relating to the technical field of drug examination equipment, the invention especially relates to an intelligent numerical control bionic drug dissolubility tester, which comprises a stomach and intestine bionic device, a loading slot and a controller. The stomach and intestine bionic device includes a bionic stomach, a bionic intestinal tract communicated with the bionic stomach, a peristaltic pump and an extruding gear. The peristaltic pump and the extruding gear are against the external surface of the bionic stomach and the external surface of the bionic intestinal tract. The invention makes bionic design for the stomach and intestine in vitro, and simulates human body gastrointestinal peristalsis and the process of digestion and absorption. With the advantages of high automation degree, good detection result reappearance, and good?in vitro and in vivo correlation, the tester can better predict the drug dissolubility in vivo.

Description

technical field [0001] The invention relates to the technical field of drug testing equipment, in particular to an intelligent numerically controlled bionic drug dissolution tester, which is suitable for drug dissolution testing, new drug development, and research on establishing in vivo and in vitro correlations. Background technique [0002] The drug dissolution rate directly affects the absorption and utilization of the drug in the body, and is an important internal index for evaluating the quality of the drug. This index needs to be investigated in the inspection of drug production, clinical efficacy, and drug stability. [0003] The detection instrument of drug dissolution mainly relies on manually extracting the liquid medicine from the dissolution apparatus at the beginning, and after filtering, it is detected by analysis methods such as ultraviolet spectrophotometry and HPLC. This method of manual sampling for detection is not highly automated and manual There are ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15G01N1/36F04B43/12
Inventor 赵文昌宋丽军温凯航吕思敏姚卫武林玉燕李伟舜
Owner GUANGDONG MEDICAL UNIV
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