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Calcium rosuvastatin and fenofibric acid choline salt time-selecting osmotic pump controlled release tablet and preparation method thereof

A technology of fenofibric acid choline salt and rosuvastatin calcium, which is applied in the field of pharmaceutical preparations and can solve the problem of single curative effect

Inactive Publication Date: 2013-10-23
肖广常
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs all have good efficacy, but the curative effect is single and cannot meet the needs of patients. Therefore, it is of great significance to develop compound preparations with multiple curative effects.

Method used

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  • Calcium rosuvastatin and fenofibric acid choline salt time-selecting osmotic pump controlled release tablet and preparation method thereof
  • Calcium rosuvastatin and fenofibric acid choline salt time-selecting osmotic pump controlled release tablet and preparation method thereof
  • Calcium rosuvastatin and fenofibric acid choline salt time-selecting osmotic pump controlled release tablet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054]

[0055]

[0056] Preparation:

[0057] (1) According to the above prescription, the raw and auxiliary materials of the drug-containing layer and the booster layer are sieved and mixed to granulate, and the drug-containing layer and the booster layer are compressed into a double-layer tablet core by two-time tablet compression technology.

[0058] (2) Preparation of coating solution: Add cellulose acetate and polyethylene glycol to an appropriate amount of ethanol, stir until completely dissolved, continue stirring for several minutes, and set aside.

[0059] (3) Coating the prepared tablet core with the above-mentioned coating solution.

[0060] (4) Make a small hole with a diameter of about 0.6 mm on one side of the drug-containing layer with a laser or a machine.

[0061] (5) Dissolving rosuvastatin calcium, polyethylene glycol and sodium bicarbonate in 50% ethanol.

[0062] (6) Spray the above-mentioned rosuvastatin calcium solution on the osmotic pump tabl...

Embodiment 2

[0065]

[0066]

[0067] Preparation method: with embodiment 1

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Abstract

The invention provides a compound preparation consisting of calcium rosuvastatin and a fenofibric acid choline salt time-selecting osmotic pump controlled release tablet and a preparation method thereof. The compound preparation structurally comprises the following components from inside to outside in sequence: a tablet chip consisting of a medicine containing layer and a boosting layer, a controlled release coating for a medicine release hole, a calcium rosuvastatin quick release layer and a protective gastric soluble thin film coating. The preparation method comprises the following steps of: (1) preparing the medicine containing layer; (2) preparing the boosting layer; (3) pressing the tablet chip; (5) coating a control release coating; (6) punching the coating tablet; (6) coating the calcium rosuvastatin quick release layer; and (7) coating the protective gastric soluble thin film coating.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. More specifically, the present invention relates to a time-selective osmotic pump controlled-release tablet of rosuvastatin calcium and fenofibric acid choline salt and a preparation method thereof. Background technique: [0002] In recent years, with the improvement of people's living conditions and changes in eating habits, the incidence of hypercholesterolemia and mixed dyslipidemia has gradually increased. Hypercholesterolemia and mixed blood lipid abnormalities are the main causes of atherosclerosis, which in turn cause cardiovascular and cerebrovascular diseases, including coronary heart disease, stroke, myocardial infarction, etc., which seriously endanger human health. Among various diseases, the morbidity and mortality of cardiovascular and cerebrovascular diseases rank first. [0003] In the blood lipid composition, cholesterol and triglyceride are the main causes of atheros...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/32A61K31/505A61P3/06A61K31/216A61K31/205
Inventor 孙英肖广常王建华信秀灵
Owner 肖广常
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