Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro

A micro-ecosystem, simulation experiment technology, applied in the field of human gastrointestinal system, can solve the problem of incomplete response to the digestive system, etc.

Inactive Publication Date: 2012-08-08
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Since these methods are more about the biochemical behavior of chemicals in the stomach and small intestine, and relatively less in the large intestine, they cannot fully reflect the situation of the entire digestive system

Method used

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  • Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro
  • Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro
  • Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro

Examples

Experimental program
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Embodiment 1

[0022] Embodiment 1: In the present embodiment, the process and steps of the experimental method are as follows:

[0023]1. Model establishment: The SHIME model includes five glass jars including stomach, small intestine, ascending colon, transverse colon, and descending colon. Each glass jar has a glass jar with an interlayer to store digestive juice, and the interlayer of each glass jar is connected by a plastic tube. And connected to 37 ℃ constant temperature water bath to achieve constant temperature effect. Gastric and intestinal digestive motility was simulated by stirring with a magnetic stirrer under each glass jar. The upper end of the glass jar is sealed with plexiglass, and there are several holes in the glass for adding or taking out the digestive juice in the glass jar, and the gastric acid and small intestinal juice of the stomach and small intestine are automatically added from there through automatic control (see figure 1 and figure 2 ). Based on the growth...

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Abstract

The invention relates to a simulator for the reappearance of human gastrointestinal tract and microbial ecosystem in vitro. On the basis of simulator of Human Intestinal Microbial Ecosystem (SHIME) technology of the University of Ghent in Belgium, and through technological improvement aiming at living habits of easterners, the simulator realizes the reappearance of the human gastrointestinal tract system in vitro. The simulator belongs to the technical field of analysis and determination of organic substances in microbiology, environmental science, chemistry, nutriology and pharmacology.

Description

technical field [0001] The present invention is based on the Simulator oI Human Intestinal Microbial Ecosystem (SHIME) technology of the University of Ghent, Belgium, and aims at the living habits of the oriental population to achieve technical improvements to reproduce the human gastrointestinal system in vitro . The invention belongs to the technical fields of microbiology, environmental science, chemistry, nutrition and pharmacology organic substance analysis and measurement. Background technique [0002] The use of human gastrointestinal tract simulation technology for in vitro experiments was initially applied to the study of the bioavailability of metal elements in nutritional foods. The method is also relatively simple to use hydrochloric acid solution to simulate gastric juice to extract metal elements in food. Due to the complex physiological conditions of the human digestive system, such a method cannot well reflect the real situation of the gastrointestinal tract...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/06C12R1/225C12R1/44C12R1/19C12R1/145
Inventor 余应新张帆李琛李俊岭韩姝媛
Owner SHANGHAI UNIV
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