Simulator for reappearance of human gastrointestinal tract and microbial ecosystem in vitro
A micro-ecosystem, simulation experiment technology, applied in the field of human gastrointestinal system, can solve the problem of incomplete response to the digestive system, etc.
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Embodiment 1
[0022] Embodiment 1: In the present embodiment, the process and steps of the experimental method are as follows:
[0023]1. Model establishment: The SHIME model includes five glass jars including stomach, small intestine, ascending colon, transverse colon, and descending colon. Each glass jar has a glass jar with an interlayer to store digestive juice, and the interlayer of each glass jar is connected by a plastic tube. And connected to 37 ℃ constant temperature water bath to achieve constant temperature effect. Gastric and intestinal digestive motility was simulated by stirring with a magnetic stirrer under each glass jar. The upper end of the glass jar is sealed with plexiglass, and there are several holes in the glass for adding or taking out the digestive juice in the glass jar, and the gastric acid and small intestinal juice of the stomach and small intestine are automatically added from there through automatic control (see figure 1 and figure 2 ). Based on the growth...
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Application Information
- IPC
- C12Q1/06; C12R1/225; C12R1/44; C12R1/19; C12R1/145
- Inventors
- 余应新; 张帆