366results about How to "Minimize adverse effects" patented technology

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.

A tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. The tissue shaping device includes a proximal anchor, a distal anchor, and a connector disposed between the proximal anchor and the distal anchor, the connector having a moment of inertia that varies along its length, such as by varying the connector thickness as a function of distance from one of its ends, with the smallest thickness being in the central portion of the connector.

A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes a distal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; a proximal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; and a connector disposed between the distal anchor and the proximal anchor.

Certain embodiments of the present invention provide a proximity detector having a simple configuration and an imaging system including the proximity detector. In an embodiment, a proximity detector mainly comprises: a single electrode mounted on a subject-side end of a movable member; a current feeding device for feeding a constant current to an electrostatic capacitor formed between the electrode and a ground; a discharging device for releasing charge from the electrostatic capacitor at intervals of a certain cycle; a binary-coding device for binary-coding the potential at the electrode relative to a ground based on a threshold; and a smoothing device for smoothing an output signal of the binary-coding device.

One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.

An exemplary embodiment of the present invention described and shown in the specification and drawings is a transceiver with a receiver, a transmitter, a local oscillator (LO) generator, a controller, and a self-testing unit. All of these components can be packaged for integration into a single IC including components such as filters and inductors. The controller for adaptive programming and calibration of the receiver, transmitter and LO generator. The self-testing unit generates is used to determine the gain, frequency characteristics, selectivity, noise floor, and distortion behavior of the receiver, transmitter and LO generator. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.

Various injectable or insertable uterine fibroid treatment formulations are provided, which comprise a uterine fibroid treatment agent in an amount effective to cause shrinkage or elimination of uterine fibroids. The injectable or insertable formulations are typically solids, semi-solids or high-viscosity fluids. Other aspects of the invention are directed to systems and methods for treatment of uterine fibroids.

A fluid vessel includes a base member in the form of a plate of which one surface has a concave channel and a cover plate which is bonded to the base plate so as to close an opening surface of the channel. The base member and the cover plate are bonded through a double-faced adhesive sheet. The double-faced adhesive sheet has an opening which corresponds to a formation pattern of the channel. The double-faced adhesive sheet includes a flat and smooth sheet substrate which is made of a plastic sheet having a chemical resistance as well as adhesive layers which are laminated onto both surfaces of the sheet substrate. In a state in which the cover plate is bonded to the base member, a space between the cover plate and a periphery of the channel opening is filled with an inner peripheral wall portion which defines the opening of the double-faced adhesive sheet.

A method and system of screening a player for a gaming opportunity, including obtaining disparate data of a player from a plurality of data sources, weighting the player data based on at least one business rule, and applying the weighted player data to at least one decision model to generate at least one composite score indicative of a scale of eligibility of the player for the gaming opportunity.

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

In a power supply unit, a printed circuit board is provided on which two or more different-shape components are mounted. Such components include semiconductor devices. The printed circuit board has a designated mounting surface of the board. The housing is also provided, which houses the printed circuit board and comprises a cooling member for cooling a first space formed between the mounting surface and an opposed surface in the housing. The opposed surface is opposed to the mounting surface. The cooling member is arranged at part of the opposed surface, the part of the opposed surface projects toward the semiconductor devices, and the opposed surface is opposed to the two or more types of different-shape components.

A method is provided for depositing a hard wear resistant surface onto a porous or non-porous base material of a medical implant. The wear resistant surface of the medical implant device may be formed by a Laser Based Metal Deposition (LBMD) method such as Laser Engineered Net Shaping (LENS). The wear resistant surface may include a blend of multiple different biocompatible materials. Further, functionally graded layers of biocompatible materials may be used to form the wear resistant surface. Usage of a porous material for the base may promote bone ingrowth to allow the implant to fuse strongly with the bone of a host patient. The hard wear resistant surface provides device longevity, particularly when applied to bearing surfaces such as artificial joint bearing surfaces or a dental implant bearing surfaces. An antimicrobial material such as silver may be deposited in combination with a metal to form an antimicrobial surface deposit.

A detector includes a smoke detecting section that includes a light-receiving unit at a position at which the light-receiving unit does not directly receive light emitted by a light-emitting unit in a chamber in which a labyrinth for preventing light from directly entering from the outside and an insect net covering the rim of the labyrinth are provided, the light-receiving unit receiving light scattered by smoke flowing into the chamber. An opening hole is formed open in the surface of the cover receiving hot air current, of the detector. In the cover behind the opening hole, an electrochemical gas sensor is placed to bring gas generated by a fire through the opening hole into contact with an electrolyte solution to detect the gas by an electrode.

A compensating advanced feature patch panel that can include removable modular or fixed electronic components located directly on the patch panel which are separately or in combination capable of providing advanced features such as device detection and power insertion. The patch panel provides communications between an insulation displacement connector (IDC) at a PD/User end, and any standard interface type using unshielded twisted pair cables, such as an RJ45 connector at a switch end at performance levels of at least category 3, 5, 5e, 6 and/or higher (e.g. 6e or 7) and equivalent performance levels as required by compensating for the active electronics used in providing advanced features through the use of inductive, capacitive and reactive circuit elements to compensate for advanced feature electronics.

A fuel cell with a gas diffusion media having a hydrophobic layer adjacent a flow field plate and a hydrophilic layer adjacent the membrane electrode assembly of the fuel cell. The two layers enable balanced humidification of reactant gas along with a basis for managing capillary water addition into the gas diffusion media. The combination of balanced moisture flux (via the hydrophobic layer) and the retention of water (via the hydrophilic layer) for humidifying reactant gas sustains hydration of the proton exchange membrane while preserving the catalyst at full activity.

A non-contact system utilizing an air-propagated ultrasound for monitoring biometric parameters is disclosed. A non-contact sensor transmits an ultrasonic wave toward a subject. The wave is reflected by the subject's skin surface back toward the sensor. Electronics in the sensor measure the small changes in displacement of the skin surface to derive a plurality of biometric parameters, including but not limited to respiration rate, heart rate, eye motion, and limb movement.

An exemplary embodiment of the present invention described and shown in the specification and drawings is a transceiver with a receiver, a transmitter, a local oscillator (LO) generator, a controller, and a self-testing unit. All of these components can be packaged for integration into a single IC including components such as filters and inductors. The controller for adaptive programming and calibration of the receiver, transmitter and LO generator. The self-testing unit generates is used to determine the gain, frequency characteristics, selectivity, noise floor, and distortion behavior of the receiver, transmitter and LO generator. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.