28 results about "Mitral regurgitations" patented technology

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The invention provides a mitral valve regurgitation severity assessment method based on PCG signals, which comprises the following steps: firstly, synchronously acquiring signals from a heart sound area and an environmental background by adopting a dual-channel audio acquisition technology, eliminating environmental noise and operation interference (such as clothes friction and non-uniform pressing force of a stethoscope) through a self-adaptive noise elimination algorithm, and calculating the severity of the mitral valve regurgitation severity; and carrying out segmentation processing on continuous heart sound signals of the de-noised heart sound by adopting a dynamic time window segmentation strategy to generate short-time heart sound fragments, evaluating the quality of the short-time heart sound fragments in real time by using a model based on a lightweight convolutional neural network, and filtering low-quality fragments. Then, nonlinear features are directly extracted from the short-time heart sound fragments through a deep neural network model based on a clique block, after each effective fragment is subjected to four classifications, classification results of all the fragments are integrated through a majority voting mechanism, and final mitral valve regurgitation severity judgment is generated. The classification robustness is effectively improved through multi-fragment information fusion, and the random error of single-fragment analysis is reduced.

A method for processing a sparsely populated data source, method for generating a training set for training a model to predict mitral regurgitation from echocardiograph data, and method of predicting heart failure from echocardiograph data including the steps of: retrieving echocardiograph measurement data from a plurality of patient records comprising echocardiography reports; analysing the echocardiograph data to determine unpopulated data fields; populating the unpopulated data fields with imputed echocardiograph data determined by a machine learning model; calculating a probability output from a trained model; analysing echocardiograph measurement data of individual patient records from the echocardiograph data to determine a prediction of the presence of a disease state in the patient on the basis of the calculated probability output; and associating the presence of the disease state to a prediction of heart failure in the patient.

The present invention relates to a device for transcatheter treatment of mitral valve reflux, in particular a coaptation aid element for implantation across the valve; comprising the apposition aid element and an anchor for implantation; comprising the apposition aid element and a delivery catheter; and methods for transcatheter implantation of involution elements across a heart valve.

The present invention discloses devices and methods for treating or repairing regurgitant heart valves such as the mitral valve and / or the tricuspid valve. Exemplary valvuloplasty devices can be placed in the coronary sinus to re-shape the mitral valve and reduce mitral regurgitation as well as tricuspid regurgitation. The present disclosure also provides improved techniques for cardiac pacing.

A prosthetic device for treating a native valve of a heart includes a sealing element and an anchoring element. The sealing element comprises a braided mesh material. The sealing element is dimensioned to be deployed at the native valve. The sealing element is configured to both be radially expanded and radially reduced while at a position between the native valve leaflets. The anchoring element is coupled to the sealing element and is configured to support the sealing element between the native valve leaflets.

The invention relates to medical application of an asparagine endopeptidase inhibitor in mitral valve mucus-like degeneration, and belongs to the technical field of biological medicine. The invention provides an application of an asparagine endopeptidase inhibitor in preparation of a medicine for treating mitral valve mucus-like degeneration. The invention relates to an application in preparation of a medicine for relieving mitral valve insufficiency. The invention relates to application in preparation of a medicine for inhibiting mitral valve thickening. The invention also discloses an application of the LGMN in preparing a medicine for treating mitral valve mucus-like degeneration by inhibiting the LGMN secreted by the in-situ macrophages. According to the application disclosed by the invention, the LGMN secreted by the macrophages is subjected to targeted antagonism, so that the myofibroblast transformation of the valvular interstitial cells is delayed, and a new target spot and a treatment path are provided for precise treatment of the mitral valve mucus-like degeneration.

The utility model relates to the technical field of medical instruments, in particular to a valve repairing device. The device comprises a rack (1), a gear (3) and a gear box (4), the gear (3) and part of the rack (1) are located in the gear box (4), the gear (3) is connected with the rack (1) in a meshed mode, and the rack (1) can be driven to move by rotating the gear (3). The device is suitable for repairing mitral valve and tricuspid valve regurgitation, the involution of the valve rings can be safely and effectively realized through the unique gear and rack structural design, and the problem that the valve leaflets are easy to damage in the traditional method is solved.

The present invention discloses a transcatheter implantable heart valve clip. The heart valve clip includes a fixed arm, a clamping arm, and a push rod. The fixed arm is an integral structure with two symmetric left fixed arms and right fixed arms. At the proximal end of the fixed arm, there is a fixed arm hook for connecting with the sheath hook. The clamping arm is an integral structure with two symmetric left clamping arms and right clamping arms. At the same circumferential position of the left clamping arm and the right clamping arm, there are two symmetric left pulling arms and right pulling arms. The push rod can move inside the fixed arm and the clamping arm to control the deployment angle of the pulling arms. The fixed arm is fixed together with the clamping arm fixing piece. The fixed arm can control the deployment angle through the pulling wire, and the clamping arm controls the deployment angle through the pulling arms. This heart valve clip can be implanted through a catheter and fix the heart valve by the mutual extrusion between the fixed arm and the clamping arm. It has the characteristics of simple structure and complete retrievability, and can treat heart valve diseases such as mitral regurgitation and tricuspid regurgitation.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets, to inhibit prolapse into the left atrium. At least one marginal chordae is severed, to permit leaflet closure against the band.

The present invention relates in some aspects to devices for use in transcatheter treatment of mitral regurgitation, the devices comprising steerable guide wires, implantable coaptation assist devices, anchoring systems for attachment of ventricular protrusions of implantable coaptation devices, kits, and methods of using implantable coaptation assist devices, among other methods.

The present invention relates to mitral valve repair and replacement devices and methods. An implant and method for repairing and / or replacing the function of a native mitral valve, in various embodiments, is configured to reduce or eliminate mitral regurgitation and residual mitral valve leakage. A coiled anchor with a central turn that reduces in size after implantation is used to approximate the native mitral annulus size and reshape the native mitral annulus to reduce valve leakage. A clip can be further applied to the native valve leaflets to reduce the size of the native mitral annulus and reduce leakage therethrough. An artificial heart valve can be implanted in the coiled anchor to replace and further improve the function of the valve. In some cases, an artificial valve can be implanted in the clipped valve, with the clip detached from one of the native valve leaflets to provide space for the artificial valve to expand.

The present invention discloses a valve clip with a plugging function, which includes an upper clip assembly, a lower clip assembly, a base, a locking mechanism, a connecting rod arm and a plugging mesh; the upper clip assembly and the lower clip assembly are equal in number and are matched in opening and closing to form a clamping part. The lower part of the upper clip assembly is fixedly arranged on one side of the locking mechanism, and the lower clip assembly is movably connected to the locking mechanism and is located below the upper clip assembly; the plugging mesh is arranged on the other side of the locking mechanism, that is, on both sides of the clamping part; when the upper clip assembly and the lower clip assembly are clamped, the plugging mesh is in an open state to plug the gaps on both sides of the clamping part. The valve clip effectively prevents the residual backflow leakage beside the clips after the edge-to-edge valve clip repair by arranging the plugging mesh on both sides of the clamping part, and plays a better role in reducing mitral regurgitation; through the application of the clip, the operation time can be effectively shortened, and the operation difficulty, operation risk and medical cost are reduced.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular implant. The transvalvular implant has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The transvalvular implant can include a wire form curved body The transvalvular implant can include eyelets and the center of the transvalvular implant can include an opening. The central portion can be positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. Tricuspid regurgitation can be treated by implanting in the tricuspid annulus a transvalvular bridge. The transvalvular bridge can have a first anchoring portion and a second anchoring portion. The transvalvular bridge can positioned so that the bridge extends transversely across a coaptive edges formed by the closure of the leaflets. The transvalvular bridge can be positioned between a midpoint of the anterior annulus and straddling the commissure between the posterior annulus and the septal annulus. The transvalvular bridge can be anchored to the anterior annulus, the posterior annulus, and the septal annulus.

An ultrasound system includes a processor circuit in communication with an array of acoustic elements and a display. The processor circuit receives B-mode and / or Doppler ultrasound data representative of mitral regurgitation associated with an orifice in a mitral valve. The processor circuit generates a model of the orifice and outputs a graphical representation of the model of the orifice to the display. The processor circuit generates a blood flow model of the mitral regurgitation based on the model of the orifice. The processor circuit compares the blood flow model to the Doppler data. The processor circuit changes the model of the orifice (e.g., a different shape, a different position, and / or a different orientation) such that the blood flow model is changed to match the Doppler data. The processor circuit outputs a graphical representation of the orifice with the different shape, the different position, and / or the different orientation to the display.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The present invention relates, in some aspects, to devices for use in transcatheter treatment of mitral valve regurgitation including a steerable guide wire, an implantable apposition aid, an anchoring system for attaching a ventricular protrusion of an implantable apposition device, kits, and methods of using an implantable apposition aid, among other methods.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

A system for treating mitral regurgitation may include an outer sheath having a lumen extending to a distal end of the outer sheath, an intermediate sheath slidably disposed within the lumen of the outer sheath, the intermediate sheath having a lumen extending to a distal end of the intermediate sheath, and an inner sheath slidably disposed within the lumen of the intermediate sheath, wherein the inner sheath includes a first anchor disposed within a lumen of the inner sheath, the first anchor being configured to penetrate and secure to a first papillary muscle. The intermediate sheath may include a tissue grasping mechanism at the distal end of the intermediate sheath, the tissue grasping mechanism being configured to hold and stabilize the first papillary muscle for penetration and securement of the first anchor to the first papillary muscle.

The present invention discloses a transcatheter heart valve clamping system, which includes a heart valve clamp part and a delivery system part. The heart valve clamp includes an upper clamping arm and a lower clamping arm, and the delivery system includes a delivery catheter and an operating handle. This system fixes the heart valve by the mutual clamping between the upper and lower clamping arms, and has the characteristics of simple structure, precise operation, and complete retrievability, and can treat heart valve diseases such as mitral regurgitation and tricuspid regurgitation.

The application provides a valve clamp and assembly, the valve clamp comprising a first base, a second base and a clamp; the second base is arranged at the distal end of the first base; the clamp comprises a clamp piece, a capture arm, a connecting arm and three joints; the distal end of the clamp piece is connected with the first base; the distal end of the connecting arm is rotatably connected with the second base through a joint, the proximal end of the connecting arm is rotatably connected with the capture arm through a joint, and the distal end of the capture arm is rotatably connected with the first base through a joint, so as to allow the proximal end of the capture arm to move away from or close to the clamp piece; at least one joint comprises an elastic body, the elastic body pre-stores elastic potential energy to keep the proximal end of each capture arm in a state close to the clamp piece, and the elastic body is deformed when the proximal end of the capture arm moves away from the clamp piece; when the valve clamp is used to perform edge-to-edge repair on mitral regurgitation, the clamping force of the valve clamp on the valve leaflet changes with the opening and closing of the valve, and the tearing of the valve leaflet is effectively avoided.

The invention is a prosthetic device for improving function of a mitral valve. The device includes a sealing member configured for positioning between mitral valve leaflets. The device also includes an expandable anchor frame configured to be positioned within one or more heart chambers, for maintaining the sealing member at a desired position between valve leaflets. The sealing member reduces mitral regurgitation be filling the gap that can occur between opposing leaflets of a damaged mitral valve, thus restoring proper mitral valve closure.

The utility model relates to a valve leaflet enhancing device and system, the valve leaflet enhancing device can enter the heart through a conveying device, release at the valve and capture a lesion unilateral valve leaflet, and the valve leaflet enhancing device can be used for enhancing the valve leaflet by changing the shape of the valve leaflet, shortening the distance between the valve leaflet and increasing the closing area and cooperative movement of the mitral valve. Therefore, the valve leaflet is repaired and enhanced, normal closing of the mitral valve is promoted, and related symptoms caused by incomplete closing of the mitral valve are relieved. In addition, the valve leaflet reinforcing device does not damage the original state of the valve leaflet, and the opportunity of a secondary operation is reserved.

The invention is a prosthetic device for improving function of a mitral valve. The device includes an adjustable and axisymmetrical-or-elongated sealing member configured for positioning between mitral valve leaflets. The device also includes an expandable anchor frame configured to be positioned within one or more heart chambers, for maintaining the sealing member at a desired position and size / shape between valve leaflets. The sealing member reduces mitral regurgitation be filling the gap that can occur between opposing leaflets of a damaged mitral valve, thus restoring proper mitral valve closure.

The present invention discloses a method for identifying the envelope of the mitral regurgitation spectrum and a method for measuring left atrial pressure, belonging to the field of curve correction technology. The method includes building a BCD-Unet deep learning model to complete the preliminary envelope of the Doppler spectrum curve; then post-processing the BCD-Unet deep learning model, designing a curve correction module to deal with the problem of curve misalignment, and designing a curve filling module to deal with the problem of curve breakage caused by the failure of some curves to be detected. In order to better integrate the information generated by the filling curve and the correction curve, a curve fusion module is also designed to further fuse the features of the two curves, combine the advantages of the two curves and obtain the final edge curve to meet the requirements of accurate measurement; iteratively train the model using data collected by the hospital, thereby continuously optimizing the model. The trained deep learning model has the ability to automatically track the envelope.

A control circuit for a sensorless implantable blood pump configured to determine mitral regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implantable blood pump and generate an alert if a measured amplitude of the estimated blood flow waveform does not include an inflection point between end diastole and initial systole.

To provide a prosthetic device for improving the function of a mitral valve.SOLUTION: A device includes an axisymmetrical or elongated, adjustable sealing member configured to be positioned between mitral valve leaflets. The device also includes an expandable anchor frame configured to be positioned within one or more heart chambers, for maintaining the sealing member at a desired position and size / shape between valve leaflets. The sealing member reduces mitral regurgitation by filling the gap that can occur between opposing leaflets of a damaged mitral valve, thus restoring proper mitral valve closure.SELECTED DRAWING: Figure 2A