16 results about "Mitral regurgitations" patented technology

The invention provides a mitral valve regurgitation severity assessment method based on PCG signals, which comprises the following steps: firstly, synchronously acquiring signals from a heart sound area and an environmental background by adopting a dual-channel audio acquisition technology, eliminating environmental noise and operation interference (such as clothes friction and non-uniform pressing force of a stethoscope) through a self-adaptive noise elimination algorithm, and calculating the severity of the mitral valve regurgitation severity; and carrying out segmentation processing on continuous heart sound signals of the de-noised heart sound by adopting a dynamic time window segmentation strategy to generate short-time heart sound fragments, evaluating the quality of the short-time heart sound fragments in real time by using a model based on a lightweight convolutional neural network, and filtering low-quality fragments. Then, nonlinear features are directly extracted from the short-time heart sound fragments through a deep neural network model based on a clique block, after each effective fragment is subjected to four classifications, classification results of all the fragments are integrated through a majority voting mechanism, and final mitral valve regurgitation severity judgment is generated. The classification robustness is effectively improved through multi-fragment information fusion, and the random error of single-fragment analysis is reduced.

The present invention relates to a device for transcatheter treatment of mitral valve reflux, in particular a coaptation aid element for implantation across the valve; comprising the apposition aid element and an anchor for implantation; comprising the apposition aid element and a delivery catheter; and methods for transcatheter implantation of involution elements across a heart valve.

A prosthetic device for treating a native valve of a heart includes a sealing element and an anchoring element. The sealing element comprises a braided mesh material. The sealing element is dimensioned to be deployed at the native valve. The sealing element is configured to both be radially expanded and radially reduced while at a position between the native valve leaflets. The anchoring element is coupled to the sealing element and is configured to support the sealing element between the native valve leaflets.

The invention relates to medical application of an asparagine endopeptidase inhibitor in mitral valve mucus-like degeneration, and belongs to the technical field of biological medicine. The invention provides an application of an asparagine endopeptidase inhibitor in preparation of a medicine for treating mitral valve mucus-like degeneration. The invention relates to an application in preparation of a medicine for relieving mitral valve insufficiency. The invention relates to application in preparation of a medicine for inhibiting mitral valve thickening. The invention also discloses an application of the LGMN in preparing a medicine for treating mitral valve mucus-like degeneration by inhibiting the LGMN secreted by the in-situ macrophages. According to the application disclosed by the invention, the LGMN secreted by the macrophages is subjected to targeted antagonism, so that the myofibroblast transformation of the valvular interstitial cells is delayed, and a new target spot and a treatment path are provided for precise treatment of the mitral valve mucus-like degeneration.

The utility model relates to the technical field of medical instruments, in particular to a valve repairing device. The device comprises a rack (1), a gear (3) and a gear box (4), the gear (3) and part of the rack (1) are located in the gear box (4), the gear (3) is connected with the rack (1) in a meshed mode, and the rack (1) can be driven to move by rotating the gear (3). The device is suitable for repairing mitral valve and tricuspid valve regurgitation, the involution of the valve rings can be safely and effectively realized through the unique gear and rack structural design, and the problem that the valve leaflets are easy to damage in the traditional method is solved.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets, to inhibit prolapse into the left atrium. At least one marginal chordae is severed, to permit leaflet closure against the band.

The present invention relates in some aspects to devices for use in transcatheter treatment of mitral regurgitation, the devices comprising steerable guide wires, implantable coaptation assist devices, anchoring systems for attachment of ventricular protrusions of implantable coaptation devices, kits, and methods of using implantable coaptation assist devices, among other methods.

The present invention relates to mitral valve repair and replacement devices and methods. An implant and method for repairing and / or replacing the function of a native mitral valve, in various embodiments, is configured to reduce or eliminate mitral regurgitation and residual mitral valve leakage. A coiled anchor with a central turn that reduces in size after implantation is used to approximate the native mitral annulus size and reshape the native mitral annulus to reduce valve leakage. A clip can be further applied to the native valve leaflets to reduce the size of the native mitral annulus and reduce leakage therethrough. An artificial heart valve can be implanted in the coiled anchor to replace and further improve the function of the valve. In some cases, an artificial valve can be implanted in the clipped valve, with the clip detached from one of the native valve leaflets to provide space for the artificial valve to expand.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular implant. The transvalvular implant has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The transvalvular implant can include a wire form curved body The transvalvular implant can include eyelets and the center of the transvalvular implant can include an opening. The central portion can be positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. Tricuspid regurgitation can be treated by implanting in the tricuspid annulus a transvalvular bridge. The transvalvular bridge can have a first anchoring portion and a second anchoring portion. The transvalvular bridge can positioned so that the bridge extends transversely across a coaptive edges formed by the closure of the leaflets. The transvalvular bridge can be positioned between a midpoint of the anterior annulus and straddling the commissure between the posterior annulus and the septal annulus. The transvalvular bridge can be anchored to the anterior annulus, the posterior annulus, and the septal annulus.

An ultrasound system includes a processor circuit in communication with an array of acoustic elements and a display. The processor circuit receives B-mode and / or Doppler ultrasound data representative of mitral regurgitation associated with an orifice in a mitral valve. The processor circuit generates a model of the orifice and outputs a graphical representation of the model of the orifice to the display. The processor circuit generates a blood flow model of the mitral regurgitation based on the model of the orifice. The processor circuit compares the blood flow model to the Doppler data. The processor circuit changes the model of the orifice (e.g., a different shape, a different position, and / or a different orientation) such that the blood flow model is changed to match the Doppler data. The processor circuit outputs a graphical representation of the orifice with the different shape, the different position, and / or the different orientation to the display.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The present invention relates, in some aspects, to devices for use in transcatheter treatment of mitral valve regurgitation including a steerable guide wire, an implantable apposition aid, an anchoring system for attaching a ventricular protrusion of an implantable apposition device, kits, and methods of using an implantable apposition aid, among other methods.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The application provides a valve clamp and assembly, the valve clamp comprising a first base, a second base and a clamp; the second base is arranged at the distal end of the first base; the clamp comprises a clamp piece, a capture arm, a connecting arm and three joints; the distal end of the clamp piece is connected with the first base; the distal end of the connecting arm is rotatably connected with the second base through a joint, the proximal end of the connecting arm is rotatably connected with the capture arm through a joint, and the distal end of the capture arm is rotatably connected with the first base through a joint, so as to allow the proximal end of the capture arm to move away from or close to the clamp piece; at least one joint comprises an elastic body, the elastic body pre-stores elastic potential energy to keep the proximal end of each capture arm in a state close to the clamp piece, and the elastic body is deformed when the proximal end of the capture arm moves away from the clamp piece; when the valve clamp is used to perform edge-to-edge repair on mitral regurgitation, the clamping force of the valve clamp on the valve leaflet changes with the opening and closing of the valve, and the tearing of the valve leaflet is effectively avoided.

A control circuit for a sensorless implantable blood pump configured to determine mitral regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implantable blood pump and generate an alert if a measured amplitude of the estimated blood flow waveform does not include an inflection point between end diastole and initial systole.