Application of BAPTA derivative in the preparing process of clinical medicine

A technology of derivatives and drugs, which is applied in the application field of BAPTA derivatives in the preparation of clinical drugs, can solve the problems of no BAPTA derivatives medicinal research, can not be used in human body, and unsolved key problems of pharmacy, so as to reduce the blood pressure of blood vessels. Permeability, inhibition of cerebral edema, and effect of reducing brain index

A technology of derivatives and drugs, which is applied in the application field of BAPTA derivatives in the preparation of clinical drugs, can solve the problems of no BAPTA derivatives medicinal research, can not be used in human body, and unsolved key problems of pharmacy, so as to reduce the blood pressure of blood vessels. Permeability, inhibition of cerebral edema, and effect of reducing brain index

CN1273125CInactive Publication Date: 2006-09-06HENGXING PHARMA INST HEFEI
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  • Application of BAPTA derivative in the preparing process of clinical medicine
  • Application of BAPTA derivative in the preparing process of clinical medicine
  • Application of BAPTA derivative in the preparing process of clinical medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Non-limiting examples are described as follows:

[0029] 1. Preparation of liposomes

[0030] Dissolve 0.1mmol of phospholipid, 0.1mmol of cholesterol and 0.08mmol of BAPTA-AM (hereinafter referred to as TM) in chloroform, and use a thin film rotary evaporator to decloud the chloroform under vacuum. A uniform dry film is attached to the wall of the device, and then add phosphoric acid micro Wash solution or Tris buffer solution, and use ultrasonic treatment until the solution is clear and transparent.

[0031] 2. Preparation of microcapsules:

[0032] Mix and stir TM and gelatin aqueous solution to obtain an o / w emulsion, raise the temperature to 50°C, add dilute acetic acid to adjust the pH to about 3.5, add Na 2 SO 4 solution to condense into microcapsules and disperse in the emulsion, and continue to add Na 2 SO 4 The solution causes the microcapsules to settle, cool down to below 15°C, add formaldehyde solution, adjust the pH to 8-9 with NaOH to solidify the mi...

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Abstract

The present invention features that BAPTA derivative is applied in preparing medicine for treating acute great area cell death clinically. The medicine is prepared into particle preparation for the clinical salvage and treatment of acute great area cell death diseases, such as cerebral infarction, myocardial infarction, liver necrosis, ischemic kidney necrosis, necrotic pencreatitis, etc.

Description

1. Technical field [0001] The present invention relates to a novel use of a derivative of a known compound, specifically the application of BAPTA and its derivatives in the preparation of clinical medicines. It is used for the rescue and treatment of patients with acute massive cell death. 2. Background technology [0002] Ischemia and hypoxia are the main causes of acute mass cell death in the human body, such as ischemic stroke and myocardial infarction leading to the death of brain cells and cardiomyocytes. In recent years, the research on the mechanism of cell death related to ischemia and hypoxia has made great progress, which points out the direction and provides a theoretical basis for the research and development of powerful drugs to protect cells from death. [0003] Mr. Zhang Juntian, a famous pharmacologist, discussed intracellular calcium overload in the book "Modern Pharmacological Experimental Methods" and pointed out that intracellular calcium overload caused...

Claims

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Application Information

Patent Timeline
06 Sep 2006
Publication
CN1273125C
IPC
A61K31/195; A61K31/21; A61P43/00; A61P9/10; A61K31/205; A61K31/225
CPC
A61K31/195; A61K31/205; A61K31/225; A61P9/10; A61P39/04; A61P43/00
Inventors
宋必卫; 刘经星