Application of BAPTA derivative in the preparing process of clinical medicine
A technology of derivatives and drugs, which is applied in the application field of BAPTA derivatives in the preparation of clinical drugs, can solve the problems of no BAPTA derivatives medicinal research, can not be used in human body, and unsolved key problems of pharmacy, so as to reduce the blood pressure of blood vessels. Permeability, inhibition of cerebral edema, and effect of reducing brain index
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[0028] Non-limiting examples are described as follows:
[0029] 1. Preparation of liposomes
[0030] Dissolve 0.1mmol of phospholipid, 0.1mmol of cholesterol and 0.08mmol of BAPTA-AM (hereinafter referred to as TM) in chloroform, and use a thin film rotary evaporator to decloud the chloroform under vacuum. A uniform dry film is attached to the wall of the device, and then add phosphoric acid micro Wash solution or Tris buffer solution, and use ultrasonic treatment until the solution is clear and transparent.
[0031] 2. Preparation of microcapsules:
[0032] Mix and stir TM and gelatin aqueous solution to obtain an o / w emulsion, raise the temperature to 50°C, add dilute acetic acid to adjust the pH to about 3.5, add Na 2 SO 4 solution to condense into microcapsules and disperse in the emulsion, and continue to add Na 2 SO 4 The solution causes the microcapsules to settle, cool down to below 15°C, add formaldehyde solution, adjust the pH to 8-9 with NaOH to solidify the mi...
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