4 results about "Metal Chelator" patented technology

The present invention relates to zwitterionic metal chelators and their use as imaging agents, diagnostic agents, chemical processing agents, and therapeutic agents. These zwitterionic metal chelators have desirable properties of maximizing solubility in aqueous environments, minimizing non-specific interactions, and retaining targeting ability, resulting in improved performance in a variety of medical, agricultural, and chemical processes. In vivo and medical applications, the zwitterionic metal chelators improve signal-to-background ratios and therapeutic windows compared to other metal chelators, while retaining high stability.

This application belongs to the field of photodetector technology, and relates to a method for preparing a metal-doped A2BX5 crystal, a thin film thereof, and a photodetector. The method for preparing the metal-doped A2BX5 crystal includes providing a first mixed solution comprising AX, BX2, CX2, and a first solvent; subjecting the first mixed solution to a first heat treatment to obtain a second mixed solution; adding a metal chelating agent to the second mixed solution to obtain a third mixed solution; adding a second solvent to the third mixed solution and performing a second heat treatment to obtain a metal-doped A2BX5 crystal, wherein C is doped in the A2BX5 crystal. The metal chelating agent can bind with B ions in the third mixed solution to form a dynamic supramolecular coordination structure, thereby limiting the nucleation rate of B ions and improving the stability of the metal-doped A2BX5 crystal.

Provided herein are peptides and conjugates (e.g., radiopharmaceutical conjugates) having avidity for a somatostatin receptor and uses thereof. The conjugate can comprise a 6-mer peptide, such as a monocyclic 6-mer peptide, a metal chelator, and optionally a linker connecting the peptide to the chelator. The radiopharmaceutical conjugate can further comprise a radionuclide bound to the metal chelator. Further provided herein are methods of preparing the conjugates, and methods of treating cancer by administering the described conjugates to a subject in need thereof.

The present invention relates to zwitterionic metal chelators and their use as imaging, diagnostic, chemical processing, and treatment agents. These zwitterionic metal chelators have desirable properties that maximize solubility in aqueous environments, minimize non-specific interactions, and retain the ability to target thus resulting in an improved performance in a variety of medical, agricultural, and chemical processes. In in vivo and medical applications, zwitterionic metal chelators improve the signal-to-background ratio and therapeutic window as compared to other metal chelators while retaining high stability.