The application discloses a combination of intestinal microbial functional markers for diagnosing allergic risk of infants and young children and a construction method and application of a model thereof. The combination of intestinal microbial functional markers for diagnosing allergic risk of infants and young children and the kit thereof can accurately and efficiently diagnose the microecological allergic risk of infants and young children of different ages. By integrating multi-dimensional characteristics such as functional
gene abundance and KEGG
metabolic pathway function
activity level, the model can reveal the core mechanism of affecting the
host immunity from the perspective of the function of the
flora, thereby improving the prediction efficiency and enhancing the biological
interpretability of the model. The AUC of the method reaches 0.84 on the
test set, indicating that the method has good ability to distinguish allergic and non-allergic individuals. The models of different
age groups all have high consistency, proving that the method is stable and reliable and can meet the accuracy requirements of clinical auxiliary decision-making.