Colchicine composition for external use and preparation method thereof
A composition for external use, the technology of colchicine, applied in colchicine liniment, the field of colchicine external composition for preventing or treating gouty arthritis, can solve the problem of not yet formed, inconsistent severity of toxicity, absorption of vitamin B12 It can relieve pain, take effect quickly, and have no systemic side effects.
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Embodiment 1
[0032] Embodiment one, the prescription research of colchicine liniment
[0033] 1 Instruments and reagents
[0034] 1.1 Instrument
[0035] Agilont 1260 high performance liquid chromatograph (Agilent company) includes G131K quaternary gradient pump, G13298 sample injector, G1316A column thermostat, G1315D DAD detector, and the workstation is: Chemstation for LC 3D systems. VV-1800 UV-Vis Spectrophotometer (Shimadzu, Japan); KS-2500 Ultrasonic Instrument (Ningbo Kesheng Instrument Factory); pH 211A Acidity Meter (Italy HANNA); BP211D Precision Electronic Balance (Sartorius, Germany); ZORBAX C 18 Chromatographic column (150mm×4.60mm, 5μm, Agilent company); YB-3 clarity detector (Tianjin University Precision Instrument Factory); DHG-9140A electric heating constant temperature blast drying oven (Shanghai-Heng Technology Co., Ltd.); SDC- Type II high-purity water device (Institute of Health Equipment, Academy of Military Medical Sciences); SHZ-D (III) circulating water vacuum p...
Embodiment 2
[0100] Embodiment 2, the anti-inflammatory effect of colchicine liniment on gout model animals
[0101] 1. Materials and methods
[0102] 1.1 Drugs and reagents Colchicine liniment (prescription 4 in Table 1-1, also 2.5.1 prescription i in Example 1, colchicine content is 0.2w / v%), colchicine (Yunnan Kunming Pharmaceutical Co., Ltd. Company pharmaceutical factory, content 99.79%), sodium urate (provided by Sigma company), prostaglandin E2 (PGE2) radioimmunoassay kit (provided by Beijing East Asia Institute of Immunology Technology), tumor necrosis factor-α (TNF-α) kit ( Institute of Military Medical Sciences).
[0103] 1.2 Experimental animals SD rats, male, clean grade, weighing 200-250g, were provided by the Experimental Animal Center of the Academy of Military Medical Sciences, and were tested after 3 days of normal feeding in the laboratory.
[0104] 1.3 Method
[0105] 1.3.1 Establishment of acute gouty arthritis model according to CODERRE classic method (Coderre TJ, W...
Embodiment 3
[0125] Example 3: Research on irritation and sensitization of colchicine liniment to skin
[0126] Toxicology research is a key link in drug research and development, which determines whether the drug can enter the clinic and whether the drug is safe to use. Chemical drug irritation and allergy refer to chemical drug preparations administered through eyes, ears, nose, oral cavity, respiratory tract, joint cavity, skin, rectum, vagina, vein, artery, muscle, subcutaneous, paravenous and intrathecal, etc. Drugs, local toxicity (such as irritation and allergy, etc.) and / or systemic toxicity (such as anaphylaxis and hemolysis, etc.) produced by the drug. It is an integral part of the preclinical safety evaluation.
[0127] The colchicine liniment of the present invention is a novel dosage form of colchicine. The invention of this dosage form is based on the fact that the effective therapeutic dose under the oral dose of the colchicine tablet is close to the systemic poisoning dose, ...
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