Azelastine composition and use

A kind of technology of azelastine and composition, applied in the field of liquid composition of azelastine

Active Publication Date: 2014-12-03
GUIZHOU YUNFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that there are many limitations of azelastine as nasal or ophthalmic administration, for example, they are usually only used clinically for the treatment of allergic seasonal rhinitis and allergic perennial rhinitis

Method used

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  • Azelastine composition and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Embodiment 1: preparation pharmaceutical composition

[0138] formula:

[0139] Azelastine Hydrochloride

[0140] Propylene Glycol

[0141] Preparation method: make azelastine or its pharmaceutically acceptable salt and transdermal absorption enhancer miscible with the polyhydric alcohol; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol fatty acid Esters to the full amount, that is, too. The liquid drug composition can be further subpackaged into liniment and spray containers respectively to make liniment and spray, so as to facilitate clinical use (all the following embodiments can be handled in this way).

Embodiment 2

[0142] Embodiment 2: preparation pharmaceutical composition

[0143] formula:

[0144] Azelastine Hydrochloride

[0145] Preparation method: make azelastine or its pharmaceutically acceptable salt and transdermal absorption enhancer miscible with the polyhydric alcohol; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol fatty acid Esters to the full amount, that is, too.

Embodiment 3

[0146] Embodiment 3: preparation pharmaceutical composition

[0147] formula:

[0148] Azelastine Hydrochloride

[0149] Preparation method: make azelastine or its pharmaceutically acceptable salt and transdermal absorption enhancer miscible with the polyhydric alcohol; then mix the obtained mixed solution with an appropriate amount of polyhydric alcohol fatty acid ester, and add polyhydric alcohol fatty acid Esters to the full amount, that is, too.

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PUM

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Abstract

The invention relates to an azelastine composition and use, specifically relates to liquid compositions of azelastine, particularly relates to liquid compositions of azelastine hydrochloride and more particularly relates to a nonaqueous liquid composition. In one embodiment, the pharmaceutical composition contains azelastine or pharmaceutical salt thereof, polyhydric alcohol, polyethylene glycol and polyhydric alcohol fatty acid ester. The invention further relates to a preparation method of the liquid composition and pharmaceutical use of the liquid composition, for example, the invention further relates to the use of the composition in the treatment, relief or prevention of symptoms related to allergic and non-allergic diseases and the use in the treatment of dermatitis, such as allergic and / or contact dermatitis. The pharmaceutical composition disclosed by the invention can be in the dosage form of liniment or spray, so as to facilitate clinical use.

Description

technical field [0001] The present invention relates to a liquid composition of azelastine, in particular to a liquid composition of azelastine hydrochloride, and more particularly to a non-aqueous liquid composition. The invention also relates to processes for the preparation of such liquid compositions and their pharmaceutical use, for example the use of such compositions for the treatment, alleviation or prevention of symptoms associated with allergic and non-allergic diseases, and for example in the treatment of dermatitis For example use in allergic and / or contact dermatitis. The compositions of the present invention have unexpected pharmaceutical properties. In particular, the liquid composition of azelastine of the present invention can be provided in a suitable pharmaceutical packaging form, so as to be provided for clinical use in conventional liniments or sprays. Background technique [0002] Azelastine, its hydrochloride (azelastine hydrochloride) is commonly us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/08A61K31/55A61K47/10A61K47/14A61P37/08A61P17/00A61P11/02
Inventor 高永良黄维崧
Owner GUIZHOU YUNFENG PHARMA
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