Azelastine composition and use

Abstract

The invention relates to an azelastine composition and use, specifically relates to liquid compositions of azelastine, particularly relates to liquid compositions of azelastine hydrochloride and more particularly relates to a nonaqueous liquid composition. In one embodiment, the pharmaceutical composition contains azelastine or pharmaceutical salt thereof, polyhydric alcohol, polyethylene glycol and polyhydric alcohol fatty acid ester. The invention further relates to a preparation method of the liquid composition and pharmaceutical use of the liquid composition, for example, the invention further relates to the use of the composition in the treatment, relief or prevention of symptoms related to allergic and non-allergic diseases and the use in the treatment of dermatitis, such as allergic and / or contact dermatitis. The pharmaceutical composition disclosed by the invention can be in the dosage form of liniment or spray, so as to facilitate clinical use.

Description

technical field

[0001] The present invention relates to a liquid composition of azelastine, in particular to a liquid composition of azelastine hydrochloride, and more particularly to a non-aqueous liquid composition. The invention also relates to processes for the preparation of such liquid compositions and their pharmaceutical use, for example the use of such compositions for the treatment, alleviation or prevention of symptoms associated with allergic and non-allergic diseases, and for example in the treatment of dermatitis For example use in allergic and / or contact dermatitis. The compositions of the present invention have unexpected pharmaceutical properties. In particular, the liquid composition of azelastine of the present invention can be provided in a suitable pharmaceutical packaging form, so as to be provided for clinical use in conventional liniments or sprays. Background technique

[0002] Azelastine, its hydrochloride (azelastine hydrochloride) is commonly us...

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