Composition comprising the extract of actinidia arguta and related species for the prevention and treatment of allergic disease and non-allergic inflammatory disease

Abstract

The present invention provides a pharmaceutical composition comprising the extract of hardy kiwifruit as an active ingredient in an effective amount to treat and prevent allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum and reducing the level of Th2 cytokines and IgE in serum. The present invention also provides a use of above extract for the preparation of pharmaceutical composition. The present invention also provides a health food or food additives, a cosmetic composition, a feed or feed additives comprising above extract for prevention or alleviation of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This application is a continuation patent application of U.S. Provisional Application No. 60 / 405,295 filed on Aug. 23, 2002, which was now abandoned.DESCRIPTION [0002] 1. Field of the Invention [0003] The present invention relates to an extract of Actinidia arguta and related species and a composition comprising the same having preventing and treating activity of allergic disease and non-allergic inflammatory disease. [0004] 2. Background of the Invention [0005] Allergic diseases such as anaphylaxis, allergic rhinitis, asthma, atopic dermatitis, food allergies and urticaria, inflict up to 20% of the population in many countries and are increasing in prevalence (Wuthrich B., Int. Arch. Allergy Appl. Immunol., 90, pp 3-10, 1989). [0006] Allergic diseases are mediated by immunoglobulin E (IgE), while the type-2 T helper (Th2) cell, mast cell and eosinophil are proven to play important roles in that process (Maggi E., Immunotechnology, 3, pp...

AI Technical Summary

Benefits of technology

[0016] The present invention provides a pharmaceutical composition comprising the extract of hardy kiwifruit as an active ingredient in an effective amount to treat and prevent allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum and reducing the level of Th2 cytokines and IgE in serum.

[0018] The present invention also provides a health food or food additives comprising above extract for prevention or alleviation of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.

[0019] The present invention also provides a feed or feed additives comprising above extract for treatment and prevention of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.

[0020] The present invention also provides a cosmetic composition comprising above extract as an active ingredient in an effective amount to treat, prevent and improve allergic skin disease and non-allergic inflammatory skin inflammation disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.

Problems solved by technology

This late-phase response can lead to chronic tissue inflammation continuously exposed to antigens.

These drugs are useful mainly for symptomatic effects, and fail to provide with such treatments that the fundamental cure of allergic diseases such as alleviating excessive humoral immunity or suppressing IgE production is required.

However, there have been no report or suggestion about the treatment and prevention of allergic disease and non-allergic inflammatory disease using by Actinidia fruit.

However, there has been not reported or disclosed about anti-allergic and anti-inflammatory action of hardy kiwifruit extract in any of above literatures.

Images