38 results about "Th2 cytokines" patented technology

A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.

A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced.

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means suchas viral infections like HIV and AIDS, or the development of neoplasms in a mammalian subject. The methods and compositions of the invention are effective for inhibiting de novo HIV infection, upregulating viral expression from latent provirus, inhibiting HIV-induced cytopathic effects, down regulating the HIV receptor, increasing ThI cytokine expression, decreasing Th2 cytokine expression, increasing ERK phosphorylation, inducing apoptosis in malignant cells, inducing remission, maintaining remission, as chemotherapeutic agents, as well as for decreasing symptoms of cytopathic diseases and opportunistic infections that may accompany such diseasesl. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent such as those used in HAART protocols, therapeutic agents used to treat opportunistic infections due to HIV, or chemotherapeutic agents to yield more effective treatment tools against cytopathic diseases in mammalian subjects.

The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase-mediated interaction of T-bet with GATA-3, as well as methods of use therefore.

The present invention provides a pharmaceutical composition comprising the extract of hardy kiwifruit as an active ingredient in an effective amount to treat and prevent allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum and reducing the level of Th2 cytokines and IgE in serum. The present invention also provides a use of above extract for the preparation of pharmaceutical composition. The present invention also provides a health food or food additives, a cosmetic composition, a feed or feed additives comprising above extract for prevention or alleviation of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.

The present invention relates to altering the levels of Th2 cytokine production, and in particular, biasing the cytokine expression profile towards Th2 cytokine production through mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1), the screening of agents that increase Th2 cytokine production, and the treatment of Th1 associated autoimmune diseases in vivo. In one embodiment, the present invention relates to agents including but not limited to reducing the activity of MEKK1, leading to increased levels of Th2 cytokine production.

This invention provides improved methods for production of monoclonal antibodies against a protein of interest. The present methods are based on immunization of an animal with a fusion protein between a protein of interest and a Th2 cytokine such as IL-4, IL-5, IL-13 and IL-31.

The invention discloses application of bamboo shaving polysaccharides in immunoregulation and tumor resisting. The bamboo shaving polysaccharides have the polysaccharide content not lower than 94.2% and are free of protein; tumors comprise gastric cancer, lung cancer, liver cancer and the like. According to the application, the bamboo shaving polysaccharides (BSPs) are applied to the preparation of anticancer drugs and immunoregulators, and the expression of Th1/Th2 cytokines is enhanced, so that the bamboo shaving polysaccharides are applied for cancer therapy.

A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders, methods for diagnosing susceptibility to, and assessing treatment of atopic allergy or asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. The use of this protein as a therapeutic agent for the treatment of autoimmune diseases is also indicated.

The present invention aims to provide a DNA vaccine for Alzheimer's disease.

The present invention provides a recombinant vector which comprises DNA encoding amyloid β and DNA encoding a Th2 cytokine, as well as a DNA vaccine for Alzheimer's disease which comprises this vector.

The invention discloses application of tetrahydrocurcumin in treating allergic asthma. The therapeutic action of the tetrahydrocurcumin (THC) on allergic asthma is firstly found and proved; from the perspective of immunity, the THC can be beneficial to alleviating nose allergy and itching, inhibiting lung eosinophilic granulocyte infiltration, reducing lung goblet cell grume generation, reducing lung collagen deposition, and inhibiting Th2 cell factor production, can provide beneficial information for clinic disease evaluation, and has a favorable application prospect in asthma treatment.

Methods are provided for the treatment of allergic and other immune disorders associated with overproduction of Th2 type cytokines by antigen specific T cells. Immunotherapy with adjuvants, as provided in the present invention, greatly inhibits the development of airway hyperreactivity and airway inflammation. Such immunotherapy is shown to reverse ongoing airway disease, and convert allergic inflammatory responses into protective immune responses. Conditions of particular interest include allergic conditions associated with production of Th2 cytokines and/or IgE antibodies, asthma, allergic rhinitis, and anaphylactic reactions. The addition of adjuvant induces a Th1-type immune response and can redirect an established Th2-type response to a Th1-type response for the selected antigen. Preferably, antigen-specific IgE production is reduced without altering the intensity of the antigen-specific proliferative response. One particularly preferred adjuvant for use in accordance with the present invention is a Listeria adjuvant.

The invention belongs to the technical field of genetic engineering and specifically relates to an inference sequence capable of inhibiting diabetes mellitus type I specificity-related gene expression as well as a recombinant vector thereof and an application of the recombinant vector in preparing a medicine for treating diabetes mellitus type I. The recombinant vector constructed by the inference sequence is used for transfecting mouse T lymphocytes, so that secretion of Th1/Th2 cell factors can be affected, and therefore, the recombinant vector plays an important role in insulitis at a prediabetic state, and blocks a process of the diabetes mellitus type I. The invention provides a novel means for treating the diabetes mellitus type I.

The present invention is about a pharmaceutical composition, an oral preparation, and an injection preparation containing a G protein-coupled Receptor19 (GPCR19) agonist, specifically sodium taurodeoxycholate (HY2191) and its derivative, as an active ingredient for preventing or treating allergic skin diseases. The present invention is also about an external preparation and a cosmetic composition containing said pharmaceutical composition for preventing and improving allergic skin diseases. The said pharmaceutical composition shows an excellent efficacy in treating and improving allergic dermatitis compared with the steroid ointments or immunosuppressive ointments currently used. The said pharmaceutical composition reduces the level of serum IgE, which is a major factor causing allergic dermatitis, increases TH1 cytokine alleviating allergic dermatitis and reduces TH2 cytokine that exacerbates allergic dermatitis. The said pharmaceutical composition also reduces infiltration of a mast cell, eosinophil, and neutrophil in dermis and ameliorates clinical symptoms such as erythema, hemorrhage, edema, excoriation, erosion, scaling and dryness. Thus, the said pharmaceutical composition can be used to prevent and treat allergic skin diseases.

The invention discloses a reverse transcription primer which can be applied to relative quantification detection of relevant cell factors of a Thl/Th2 cell, a plurality of associatively amplified gene specific primers and a kit. The kit comprises a reagent A: 50muL of 5muM reverse transcription primer, a reagent B: 50muL of 20U/muL M-MuLV reverse transcriptase, a reagent C: 200muL of 5*reverse transcription buffer solution containing 5mM of dNTP (deoxy-ribonucleoside triphosphate) including dATP (deoxyadenosine triphosphate), dCTP (deoxycytidine triphosphate), dGTP (deoxyguanosine triphosphate) and dTTP (deoxythymidine triphosphate)], 250mM of Tris-HCl, 250mM of KCl, 20mM of MgCl2 and 50nM of DTT (dithiothreitol), a reagent D: 2*PCR (Polymerase Chain Reaction) buffer solution, wherein 1mL of buffer solution contains 100 U of taq enzyme, 600nM of ROX (roxithromycin), Green I dye, 2mM of dNTPs (including dATP, dCTP, dGTP and dTTP), 80mM of Tris-HCl, 80mM of KCl, 40mM of (NH4)2SO4 and 6mM of MgSO4, and 24 primer-containing PCR 8 cascade reaction tubes. The entire set of kit provided by the invention can be applied to relative quantification of the cell factors of the Thl/Th2 cell; moreover, relative quantification analysis can be performed on mRNA (messenger ribonucleic acid) fragments of six types of cell factors of different types of T cells, and the immune state of an individual can be estimated according to a result.

The invention belongs to the field of airway inflammation medicine application, and relates to application of itaconic acid in preparation of a medicine for treating or relieving allergic airway inflammation diseases. In the application, itaconic acid inhibits lung tissue inflammatory cell infiltration, mucus secretion, Th2 cytokine generation, NLRP3 inflammasome activation and oxidative stress injury in a targeted mode for treating or relieving allergic airway inflammation. According to the application, the immune metabolite itaconic acid is introduced into the treatment of the allergic airway inflammation disease for the first time, a new method for treating or relieving the allergic airway inflammation is found, and a new target and a brand new idea are provided for preparing the medicine for treating the allergic airway inflammation disease. The itaconic acid is an endogenous immune metabolite and has the characteristics of high safety and low toxicity, and the application of the itaconic acid to the development process of drugs related to the allergic airway inflammation diseases broadens the types of drugs for treating the allergic airway inflammation diseases such as asthma, allergic bronchitis and allergic rhinitis.

The invention belongs to the technical field of medicine and particularly discloses use of ulinastatin in the preparation of drugs for treating multiple sclerosis. It is proved herein that by treating a multiple sclerosis rat (EAE model) with ulinastatin, weight reduction can be significantly reduced for the EAE rat, death rate of the EAE rat can be significantly reduced, onset latency can be significantly delayed, and neural protection can be achieved; in addition, ulinastatin can also increase TGF-beta and IL-10 expression, restore the balance of Th1/Th2 cell factors and relieve EAE process by reducing IL-2, IFN-gamma and TNF-alpha expression and can accelerate EAE recovery b adjusting apoptosis-promoting Bax and Fas proteins and inhibiting Bcl protein expression. The ulinastatin of the invention has low toxic and side effect, is high in safety, can protect heart, liver, kidney and lung, is low in cost and has a promising development prospect as a drug for treating multiple sclerosis.

The present disclosure relates to methods for diagnosing and staging keloids, and to methods of treating keloids using therapeutic compositions that inhibit the Th2 cytokine signaling pathway.