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Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof

A technology of facial redness and composition, which is applied in the direction of drug combination, pharmaceutical formula, skin care preparation, etc., can solve the problems of pigmentation and inflammatory reaction, high price, poor curative effect, etc.

Active Publication Date: 2015-04-29
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Improper care after treatment can easily cause side effects such as pigmentation and inflammatory reactions, and the price is relatively expensive, which many patients cannot accept
(Desiate A, Cantore S, Tullo D, Profeta G, Grassi FR, Ballini A. 980nm diode lasers in oral and facial practice: current state of the science and art. Int J Med Sci, 2009, 6(6): 358- 64; Wang Juan. Clinical efficacy of intense pulsed light 540nm combined with recombinant bovine basic fibroblast growth factor in the treatment of facial telangiectasia. Chinese Journal of Medical Aesthetics and Cosmetology, 2010, 16(4): 220-223) In fact, facial red blood It can be treated with external skin care products. At present, only a few French medicinal cosmetic companies (Avène, La Roche-Posay, L’Oreal) have launched cosmetics specifically for red blood vessels. Their functional ingredients are mainly for repairing capillaries, and the curative effect is not good.

Method used

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  • Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof
  • Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof
  • Pharmaceutical composition for treating facial telangiectasis and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] At room temperature, take 10 kilograms (80 kilograms in total) of pearl grass, chrysanthemum chrysantha, Tianjihuang, Gynostemma pentaphyllum, Centella asiatica, Malan, mulberry leaves and Bawangbian, soak and extract with 800 kilograms of ethanol with a volume concentration of 70%. The soaking time is 24 hours, and the residue is soaked in 800 kg of ethanol with a volume concentration of 70% for 24 hours to extract, then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 20 times under reduced pressure, and then the concentrated solution is poured into a large The porous resin is eluted with ethanol with a volume concentration of 50%, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 2

[0107] At room temperature, take 8 kg of pearl grass, 8 kg of chrysanthemum, 8 kg of Tianjihuang, 12 kg of Gynostemma, 12 kg of Centella asiatica, 12 kg of Malan, 12 kg of mulberry leaves, and 8 kg of Bawang whip (80 kg in total) , soak and extract with 800 kg of ethanol with a volume concentration of 50%, and the soaking time is 24 hours. , concentrated under reduced pressure for 40 times, and then the concentrated solution was applied to a macroporous resin, and eluted with ethanol with a volume concentration of 40%, and the collected eluate contained the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 3

[0109] At room temperature, take 8 kg of pearl grass, 8 kg of chrysanthemum, 15 kg of tianjihuang, 15 kg of gynostemma, 15 kg of centella asiatica, 15 kg of malan, 15 kg of mulberry leaves, and 8 kg of bawang whip (99 kg in total) , soak and extract with 1980 kg of ethanol with a volume concentration of 80%, and the soaking time is 24 hours. Concentrate for 25 times, then apply the concentrated solution to a macroporous resin, and elute with ethanol with a volume concentration of 60%. The collected eluent contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

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Abstract

The invention discloses a pharmaceutical composition for treating facial telangiectasis and a preparation method and use thereof. Raw materials of the pharmaceutical composition are all natural soothing ingredients and are nonirritant to skin. The pharmaceutical composition with a facial telangiectasis treating effect is prepared from phyllanthus urinaria, polygala fallax hemsl, hypericum japonicum, gynostemma pentaphyllum, centella asiatica, kalimeris indica, mulberry leaves and euphorbia royleana, wherein the weight percent of any ingredient is not higher than 30% the overall weight. The raw materials of the pharmaceutical composition disclosed by the invention are simply obtained, and the preparation method is convenient. Proved by clinical trial results, the pharmaceutical composition disclosed by the invention has a good effect on the treatment of the facial telangiectasis, is nonirritant and non-allergic to the skin, is easily accepted by mass consumers, and has good application prospect and market prospect.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its preparation method and use, in particular to a cosmetic pharmaceutical composition with the effect of treating facial redness and its preparation method and use, suitable for adding to ointments, creams, milks, Face cosmetics of the liquid type (except perfume). Background technique [0002] Facial red blood streaks, also known as facial telangiectasia in medicine, means that the elasticity of the capillary wall decreases, the fragility increases, and the blood vessels continue to expand unevenly or even rupture, resulting in redness of the facial skin and dilated capillaries visible to the naked eye. Accompanied by red or purple spots, dots, lines or stars, etc., called telangiectasia. (Domingo DS, Camouse MM, Hsia AH, Matsui M, Maes D, Ward NL, Cooper KD, Baron ED. Anti-angiogenic effects of epigallocatechin-3-gallate in human skin. Int J Clin Exp Pathol, 2010,3(7 ): 705-709) At ...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61K8/97A61P17/00A61Q19/00
Inventor 王恩瀚
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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