Topical preparation for treating acne and hirsutism

a technology for acne and hirsutism, applied in the field of topical preparations for treating acne and hirsutism, can solve the problems of no treatment approved for interfering with the conversion of testosterone to dht, no adapalene has significant comedolytic activity, and the response may take longer

Inactive Publication Date: 2002-10-24
GOODMAN DAVID S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such precursors enhance hormone responsive illness such as hirsuitism or acne in women as an undesirable side effect.
Responses on the trunk may take longer because of thicker skin in these areas and slower penetration of the products into hair follicles.
None of these approved treatments acts by interfering with the conversion of testosterone to DHT nor with the binding of DHT to androgen receptors.
First, adapalene has significant comedolytic activity, i.e., it opened comedones or clogged pores.
Third, adapalene has anti-inflammatory effects both in vitro and in vivo.

Method used

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  • Topical preparation for treating acne and hirsutism
  • Topical preparation for treating acne and hirsutism
  • Topical preparation for treating acne and hirsutism

Examples

Experimental program
Comparison scheme
Effect test

examples 1-14

[0084] Tables I and II below provide examples of preparations of the invention. The SPBE in this table is provided by Saw Palmetto Harvesting Company, Frostproof, Fla. and has a phytosterol concentration of 0.16 wt. %. The topical vehicle may be chosen appropriate to the use of the preparation as a liquid gel, a foam, a cleanser, or a pad dampened with a liquid. All percentages are by weight.

5TABLE I Constituent - % Ex. 1 Ex. 2 Ex. 3 Ex. 4 Ex. 5 Ex. 6 Ex. 7 Ex. 8 SPBE 31.25 40.0 60.0 80.0 31.25 31.25 31.25 31.25 Adapalene 0.1 -- -- -- -- -- --glycolic acid -- 5.0 -- -- -- -- --tretinoin gel or -- -- 0.025 -- -- -- --tretinoin gel micro-sponges Retinaldehyde -- -- -- 0.1 -- -- --azelaic acid -- -- -- -- 20 -- --tazarotene, -- -- -- -- -- 0.1 --salicylic acid, -- -- -- -- -- -- 2.0 retinol 1.0 Topical B B B B B B B B Vehicle B stands for Balance of the Composition

[0085]

6TABLE II Constituent - % Ex. 9 Ex. 10 Ex. 11 Ex. 12 Ex. 13 Ex. 14 Ex. 15 Ex. 16 SPBE 31.25 31.25 31.25 31.25 31.25 3...

examples 15-21

[0087] Table III below provides examples of preparations of the invention. The SPBE in this table has been purified from the SPBE provided by Saw Palmetto Harvesting Company, Frostproof, Fla. by extraction with an aqueous alkaline solution and has a phytosterol concentration of 0.5 wt %. The topical vehicle may be chosen appropriate to the use of the preparation as a liquid, a gel, a foam, a wash or a pad dampened with a liquid. All percentages are by weight.

7TABLE III Constituent - % Ex. 17 Ex. 18 Ex. 19 Ex. 20 Ex. 21 Ex. 22 Ex. 23 Ex. 24 SPBE 15.0 20.0 30.0 10.0 10.0 10.0 10.0 10.0 Adapalene 0.05 0.05 -- -- --glycolic acid 5.0 -- 1.0 5.0 -- 5.0 5.0 2.0 Tretinoin -- -- 0.025 -- 0.05 --retinaldehyde -- -- .1 -- --retinol 1.0 azelaic acid -- -- -- 15 10 -- --Tazarotene -- -- ---- -- 0.1 --salicylic acid -- 2.0 -- -- -- -- --polyolprepolymer-2 10 10 10 10 10 10 10 Topical Vehicle B B B B B B B

[0088] B Stands for Balance of the Composition

[0089] Various modifications may be made to the...

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Abstract

An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, and preferably one or more low irritability constituents that enhance penetration of the extract into hair follicle sebaceous glands. The low irritability penetration aid may be selected from the group consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, tazarotene, beta hydroxy acids (salicylic acid), azelaic acid, and alpha hydroxy acids (glycolic acid) as well as polyolprepolymer-2.

Description

[0001] This application is a Continuation-in-Part of U.S. Ser. No. 09 / 563,555 filed May 3, 2000 for the instant inventor.[0002] This invention relates to an improved preparation and method for treating both acne and hirsutism, or unwanted facial and body hair in women; and more particularly to a preparation comprising a topically active extract of saw palmetto berries, with one or more compounds which exhibit low irritability and enhance penetration of the extract into hair follicles and sebaceous glands.Pathogenens of Acne[0003] Acne is caused by a complex interaction of excessive sebum production colonization of hair follicles by Proprionibasterium acnes, and follicular plugging or comedone formation.[0004] Sebum is the oily secretion of sebaceous glands. These glands drain directly into hair follicles and are present mainly on the face, chest and back. Sebum production is predominantly controlled by androgens manufactured in the testes, adrenal glands, and ovaries. High levels of...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/04A61K8/362A61K8/365A61K8/368A61K8/37A61K8/63A61K8/67A61K8/92A61K8/97A61Q5/00A61Q5/06A61Q7/00
CPCA61K8/046A61K8/362A61K8/365A61K8/368A61K8/37A61Q7/00A61K8/671A61K8/92A61K8/97A61Q5/00A61Q5/06A61K8/63A61K8/9789
Inventor GOODMAN, DAVID S.
Owner GOODMAN DAVID S
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