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Tazarotene gelata and preparation method thereof

A kind of Roten gel, tazarotene technology, applied in tazarotene gel and its preparation, the field of pharmaceutical external preparations, can solve the hydrolysis of ethyl carboxylate group and propose a solution, gel matrix material The selection of complex problems can achieve the effect of less variety, easy coating and good stability

Inactive Publication Date: 2014-11-12
江苏小林制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the prior art, the selection of gel matrix materials is complicated, such as cetyl alcohol, vaseline, liquid paraffin, glyceryl monostearate, glycerin, solubilizers, emulsifiers, ethylparaben, etc., but none of them are effective for how Inhibition of Hydrolysis of Ethyl Carboxylate Groups in Drugs Proposes a Solution

Method used

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  • Tazarotene gelata and preparation method thereof
  • Tazarotene gelata and preparation method thereof
  • Tazarotene gelata and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Tazarotene gel prescription and preparation process

[0029]

[0030] Preparation Process:

[0031] (1) Dissolve the prescribed amount of methyl cyclodextrin in 20ml of water, add the prescribed amount of tazarotene, stir to dissolve, and obtain solution Ⅰ;

[0032] (2) Dissolve the prescribed amount of sodium alginate and ethyl p-hydroxybenzoate in 60ml of water to obtain solution II;

[0033] (3) Mix solution I and solution II, add water to 100ml, stir evenly to obtain a gel.

Embodiment 2

[0034] Embodiment 2 Tazarotene gel prescription and preparation process

[0035]

[0036] Preparation Process:

[0037] (1) Dissolve the prescribed amount of methyl cyclodextrin in 15ml of water, add the prescribed amount of tazarotene, stir to dissolve, and obtain solution I;

[0038] (2) Dissolve the prescribed amount of sodium alginate and ethyl p-hydroxybenzoate in 70ml of water to obtain solution II;

[0039] (3) Mix solution I and solution II, add water to 100ml, stir evenly to obtain a gel.

Embodiment 3

[0040] Embodiment 3 Tazarotene gel prescription and preparation process

[0041]

[0042] Preparation Process:

[0043] (1) Dissolve the prescribed amount of methyl cyclodextrin in 20ml of water, add the prescribed amount of tazarotene, stir to dissolve, and obtain solution Ⅰ;

[0044] (2) Dissolve the prescribed amount of sodium alginate and sodium benzoate in 60ml of water to obtain solution II;

[0045] (3) Mix solution I and solution II, add water to 100ml, stir evenly to obtain a gel.

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Abstract

The invention discloses a tazarotene gelata and a preparation method thereof. The preparation is prepared form the active ingredient tazarotene and auxiliary materials. The auxiliary materials include methyl cyclodextrin and sodium alginate. The preparation method includes: dissolving methyl cyclodextrin in water, adding a prescribed amount of quantity of tazarotene, conducting stirring for dissolving so as to obtain a solution I; dissolving sodium alginate and a bacteriostatic agent in water to obtain a solution II; and mixing the two solutions and stirring the mixture evenly, thus obtaining the gelata. The tazarotene gelata provided by the invention has the advantages of simple preparation process, good gel stability, few variety of auxiliary materials, and easy coating.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for external use, in particular to a tazarotene gel and a preparation method thereof. Background technique [0002] Acne is a chronic pilosebaceous gland disease caused by a combination of factors. Histological changes are first abnormal keratosis. In the infundibulum of the hair follicle, the cutin accumulates to form a plug, resulting in the formation of microcomedone. Increased sebum and further accumulation of keratinocytes make microcomedones become open or closed comedones, i.e. blackheads or whiteheads (non-inflammatory acne). The above environment is conducive to the reproduction of Propionibacterium acnes. The latter release chemokines, which cause infiltration of neutrophils, leading to the rupture of comedones, which develop into inflammatory papules or pustules (inflammatory acne). Therefore, rapidly and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/40A61K47/36A61K31/455A61P17/10
Inventor 王福东姜和平殷雨林赵亚美叶强邓建华
Owner 江苏小林制药有限公司
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