82 results about "Sebaceous gland secretion" patented technology

The invention relates to an application of a stable silicic acid aqueous solution in preparation of a product for treating acne, and the mass concentration of the stable silicic acid aqueous solution is 0.5-2%. The product taking the stable silicic acid aqueous solution as an active ingredient can be used for treating acne or preventing and / or treating sebaceous gland homeostasis imbalance, can fade the color of sebaceous gland spots at the mass concentration of 0.5-2%, and has an anti-acne effect, and meanwhile, the stable silicic acid aqueous solution is low in raw material cost, environment-friendly, safe and suitable for industrial production. The tretinoin can be used as a traditional tretinoin substitute medicine with a good curative effect.

The invention provides an application of acetyl tetrapeptide-5 in preparation of an oil control product. According to the invention, the effect of acetyl tetrapeptide-5 on human sebaceous gland cells (SZ95) is researched through cell experiments. The compound reduces the lipid content.

The invention provides a composition with oil-controlling, acne-removing, barrier-repairing effects and application thereof, and belongs to the field of cosmetics. The composition is prepared from a baropetalum beetle leaf extract, a roselle flower extract, totarol and a cryptomeria fortunei bud extract. The baropetalum chinense leaf extract has the effects of balancing grease secretion and shrinking pores; the roselle flower extract is rich in organic acid and anthocyanin, and has the effects of dissolving pore keratosuppository, controlling oil, resisting inflammation, smoothing acne skin, preserving moisture and removing redness; as a bacteriostatic agent, totarol has a natural preservative effect on gram-positive bacteria and partial negative bacteria, and has the effects of removing acnes, sterilizing, diminishing inflammation, whitening and the like; the cryptomeria fortunei bud extract can promote skin tissue structure regeneration and strengthen skin barriers. The composition effectively regulates and controls excessive secretion of sebaceous gland grease and pox skin specific protein through the synergistic effect of various components, promotes the health of pox skin, repairs the skin barrier and enhances the self-protection ability of the skin at the same time.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

The present invention provides an anti-wrinkle and firming composition containing collagen and its application in cosmetics, the composition comprises the following components in parts by weight: 20-40 parts by weight of posiin, 0.5-2.5 parts by weight of pterostilbene, 0.5-2.5 parts by weight of soluble collagen, 0.5-2.5 parts by weight of ergothioneine, 0.02-0.1 parts by weight of palmitoyl tripeptide-5 and an appropriate amount of solvent component. After posiin, pterostilbene, soluble collagen, ergothioneine and palmitoyl tripeptide-5 are matched and coordinated with each other, a very thin film layer can be formed on the surface of the skin, thereby making the skin plump and wrinkles stretched, achieving control of sebaceous gland secretion to reduce oil discharge, locking collagen, and keeping the skin fresh, and finally improving the elasticity of the skin and reducing skin wrinkles.

The invention belongs to the technical field of natural products, and provides application of fucoxanthin in preparation of oral anti-alopecia drugs. Animal experiments find that long-term high-fat diet can lead to large-piece shedding of hair accompanied by skin inflammation, and fucoxanthin has a treatment effect on high-fat diet induced mouse back hair shedding and skin inflammation, can obviously relieve high-fat diet induced subcutaneous cholesterol crystal accumulation and sebaceous gland cell hypertrophy, and has the effects of preventing and treating the high-fat diet induced mouse back hair shedding and skin inflammation and preventing and treating the high-fat diet induced mouse back hair shedding and the high-fat diet induced sebaceous gland cell hypertrophy. And skin epidermal hyperplasia and cuticle thickening induced by high fat diet can be improved. Besides, cell experiments also find that fucoxanthin intervention can reduce oleic acid infiltration of the hair follicle stem cells and reduce oleic acid induced death and apoptosis of the hair follicle stem cells, and prove that fucoxanthin has a protection effect on the hair follicle stem cells, has low toxic and side effects on cells and animals as a natural algae extract, and has a good application prospect. Good clinical application prospects are realized.

The invention discloses a composition containing saccharomycetes / rice fermentation product filtrate, which has the effects of controlling oil and repairing hair. The composition comprises saccharomycetes / rice fermentation product filtrate, a rice husk extract, a tuber melanosporum extract and a millet seed extract. The invention also provides an application of the composition in preparation of oil-controlling, repairing and washing products, shampoo containing the composition and a preparation method of the shampoo. Experimental results show that the composition can significantly inhibit grease secretion of human sebaceous gland cells, repair hair and improve smoothness and glossiness of hair. The composition disclosed by the invention has the advantages of strong synergistic effect of all components, safety, no irritation, simple preparation process and suitability for industrial production.

The invention belongs to the technical field of compositions capable of generating foam, and particularly relates to a composition containing a thiohydantoin compound. The composition contains a compound of formula (I) or a pharmaceutically acceptable salt thereof. The foam composition is convenient to use and high in stability, and can be used for treating, preventing or relieving androgen-mediated disorders, diseases or symptoms, such as acne, hirsutism, sebaceous gland enlargement or androgenetic alopecia.

The invention discloses an oil-controlling and skin-astringing composition as well as a preparation method and application thereof, and particularly belongs to the field of preparations for dressing and makeup. The composition for controlling oil and astringing skin is prepared from the following components in parts by weight: 1.5 to 2.1 parts of tea leaf extract, 7.1 to 8.6 parts of hamamelis virginiana water, 0.003 to 0.01 part of moso bamboo leaf extract, 0.036 to 0.051 part of lotus corniculatus seed extract and 0.6 to 1.2 parts of alkanet extract. The oil-controlling and skin-astringing composition provided by the invention has excellent performance of inhibiting grease secretion of human sebaceous gland cells, and has an excellent deep oil-controlling effect on skin; the resident skin external preparation provided by the invention has excellent effects of short-time oil control, lasting oil control and skin astringing.

The present invention provides a novel promoter for lipid synthesis in sebaceous gland cells. By using the novel promoter for lipid synthesis in sebaceous gland cells, a skin barrier damage repairing agent and cosmetics with a skin barrier damage repairing function can be prepared, so that cosmetics for repairing skin barrier damage of at least one type selected from skin dryness, premature skin aging, skin aging, skin pruritus, and senile sebaceous deficiency eczema caused by hypofunction of sebaceous glands and / or reduced sebum secretion can be developed.

The present application belongs to the field of daily chemicals, and particularly relates to a skin care composition containing Physocarpus fruit extract, which comprises the following components calculated by weight percentage: Physocarpus fruit extract 0.01-6.0%; humectant 0.1-15.0%; oil 5.0-30.0%; emulsifier 1.0-10.0%; thickening agent 0.1-5.0%; preservative 0.5-2.0%; and the balance of pure water. The skin care composition of the present application not only can improve the symptom of excessive secretion of sebaceous glands, dredge the blocked pores, effectively reduce the generation of comedones and inflammatory acne, but also has excellent soothing and redness fading ability, can quickly calm the existing red and swollen acne skin, and reduce the stinging and uncomfortable feeling caused by acne. In addition, after using the composition of the present application, the secretion of sweat and oil can be reduced, so as to achieve the effect of reducing body odor.

A method of treating Hidradenitis Suppurativa (HS) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

To provide a method for evaluating the therapeutic and / or prophylactic action of a skin disease caused by the obstruction and / or inflammation of a pilosebaceous gland system.SOLUTION: A method for evaluating a therapeutic and / or prophylactic action of a substance or agent on a skin disease, the method comprising: bringing the substance or agent into contact with sebocytes or progenitor cells thereof; and evaluating the sebocytes or progenitor cells thereof, wherein the skin disease is a skin disease caused by obstruction and / or inflammation of the pilosebaceous unit.SELECTED DRAWING: None

The invention provides a sebum management liquid and a preparation method thereof, and the sebum management liquid comprises the following components by mass: 2.3-4.61% of a composite plant exosome; the content of the nano-micelle is 10.45 percent to 26.2 percent; 5.3% to 18.9% of a plant extract; 2.25% to 3.35% of a conditioning agent; and the balance of water. According to the invention, the exosome derived from fresh plants is used as a nano-scale carrier, and interacts with the nano-micelles, so that more efficient active substance loading capacity and natural targeting property are ensured, and the active substances can be more accurately delivered to specific sebaceous gland cells; through combination of an exosome preparation technology and a nano-micelle technology, grease is disintegrated, excessive secretion of sebum is reduced, and formation of blackheads and acnes is prevented by reducing grease oxidation.

A method of treating Sebaceous Hyperplasia (SH) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

The invention relates to the technical field of cosmetics, in particular to a Keemun black tea-fruit composition with effects of minimizing pores and controlling oil as well as a preparation method and application of the Keemun black tea-fruit composition. The Keemun black tea-fruit composition with the effects of minimizing pores and controlling oil comprises the following components in parts by weight: 1-5 parts of a Keemun black tea extract, 0.5-3 parts of a sword bean fruit extract and 1-4 parts of a kochia scoparia fruit extract. The Keemun black tea extract, the sword bean fruit extract and the kochia scoparia fruit extract are compounded, so that the effects of minimizing pores and controlling oil are synergistically enhanced through multiple targets, 5a-reductase is effectively inhibited, the sensitivity of sebaceous glands is adjusted, and grease production is reduced from the source; the components can also act together to improve hair follicle blockage, enhance skin supporting force and shrink pores, and have cosmetic application prospects.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

This invention belongs to the field of skin care technology and discloses an oil-controlling composition, its uses, and skin care products. The oil-controlling composition, by weight, comprises 0.5-1 parts of zinc PCA, 4-9 parts of niacinamide, 0.5-2 parts of pink passionflower extract, and 0.3-0.7 parts of acetyl tetrapeptide-5. The oil-controlling composition of this invention not only inhibits 5α-reductase activity but also promotes autophagy in sebaceous gland cells, thereby enhancing the oil-controlling efficacy of the composition.

The invention discloses oil-controlling and dandruff-removing shampoo and a preparation method thereof. The shampoo comprises an anti-malassezia single-domain antibody with an amino acid sequence as shown in SEQ ID NO: 1 and an asparagus cochinchinensis root extract obtained through supercritical carbon dioxide extraction. The activity retention rate of the antibody is not lower than 80% after the antibody is stored in a shampoo matrix at 40 DEG C for 28 days. The total polyphenol content of the extract is not less than 5%. Chessboard microdilution determination shows that the antibody and the extract have a synergistic effect in the aspect of inhibiting malassezia, and the synergistic index is less than 0.9. Cell experiments show that the extract can down-regulate gene expression of 5 alpha-reductase in human sebaceous gland cells. A human body test result shows that after the shampoo is used for 4 weeks, the dandruff score of a subject is reduced by 82.5%, the scalp grease content is reduced by 64.1%, the malassezia quantity is reduced by 47.8%, and the effect is superior to that of a single component and a commercially available chemical dandruff removing product. The shampoo has excellent stability, synergistic effect and clinical application effect, and has a relatively high industrial application prospect.

The application discloses a plant extract for reducing oil secretion, which comprises 5-25 parts of citrus by weight, 3-15 parts of sophora, 3-15 parts of compositae, 3-15 parts of seaweed plant and 1-10 parts of camellia by weight; and the preparation raw material further comprises a solvent. The grapefruit, sophora and dandelion are combined to inhibit 5alpha-reductase activity from the source, inhibit sebaceous gland cell activity and reduce skin oil secretion. The large leaf seaweed and green tea are combined to have good antioxidant effect, can relieve the irritation of peroxide squalene to the skin caused by skin lipid oxidation, and avoid inflammation; meanwhile, the moisturizing component contained can reduce skin water loss, avoid excessive oil secretion caused by dry skin, and solve the problems that the existing oil control skin care and color cosmetic products cannot fundamentally solve oil secretion, have obvious side effects, have insufficient effect, and are prone to recurrence.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

Incorporation of lipids into a growing hair fibre is provided by a composition comprising at least one of: 1) 0.05 to 8 wt % of a lipid precursor selected from the group consisting of a fatty acid having a chain of 6 to 24 carbon atoms, an ester or an acylglycerol thereof and mixtures thereof; 2) 0.05 to 8.0% of a "gene activator material" that modulates the biosynthesis of lipids in the hair follicle or sebaceous gland, selected from a) at least one activator of a peroxisome proliferator-activated receptor (PPAR activator), b) at least one activator of a liver X receptor (LXR), and c) at least one activator of a retinoid X receptor (RXR); and 3) a fatty alcohol having a chain of 6 to 24 carbon atoms, preferably 8 to 20 carbon atoms, most preferably 10 to 18 carbon atoms; and mixtures thereof; and a cosmetically acceptable carrier.

The present disclosure relates, in part, to a method of treating acne, excessive sweating, unwanted hair, and / or unwanted blood vessels. The method can include providing a needle array comprising a plurality of needles; inserting the plurality of needles into a dermis of a treatment area; detecting a location of an enlarged sebaceous gland; and exciting one or more of the plurality of needles to treat the sebaceous gland, one or more sweat glands, a vascular lesion, an unwanted hair follicle, and / or an unwanted blood vessel.

To provide a technique relating to total secretion regulation of sebaceous gland cells.SOLUTION: The present invention provides a total secretion regulator comprising a compound selected from the group consisting of oligosaccharides and macrolide compounds as an active ingredient.SELECTED DRAWING: None

The invention provides application of an autoinducible factor 2 in preparation of a product for preventing or treating acne. Experiments show that the expression quantity of the autoinducible factor 2 in diseased skin tissues and sebum secretions of acne patients is obviously higher than that of healthy people; in an acne cell model, the autoinducible factor 2 can significantly up-regulate expression of inflammatory factors such as IL-1, IL-6, TNF-alpha and the like by activating an NF-kappa B pathway, and meanwhile, the secretion amount of sebum in sebaceous gland cells is promoted. Therefore, the autoinducible factor 2 serves as a new target for acne treatment, related inhibition products of the autoinducible factor 2 have definite prevention and treatment effects on acne, the autoinducible factor 2 has huge potential of being developed into corresponding drugs, medical instruments or skin care products, and meanwhile a new technical direction is provided for solving the problems of drug resistance, side effects and the like of existing acne treatment.

The present disclosure relates to phages functionalized with pharmacologically active molecules for the treatment of acne. Such phages are useful in the treatment of infectious diseases, as they target pharmacological substances to tissue colonized by bacteria. In an embodiment herein, the functionalized phages of the present invention correspond to lytic phages of the Caudoviricetes class having activity against Cutibacterium acnes with pharmacologically active molecules, specifically with isotretinoin, having properties of interest for the treatment of acne caused by Cutibacterium acnes, because it acts at the sebaceous gland level, reducing inflammation, hyperproduction of sebum, and keratosis.

The present invention refers to a composition including a fermented supernatant of Lactobacillus casei or paracasei species The species is characterized by having in its DNA genome at least one DNA sequence essentially identical to one of the sequences selected from the group consisting of: SEQ ID No 1 to 5, and proper diluents and / or carriers and / or excipients. The compositions can be used in the treatment and / or prevention of skin and / or dermatological diseases related to inflammation, allergic reactions, contact hypersensitivity reactions and intolerance, excessive sebaceous secretion, exfoliation or microbial dysbiosis, preferably of the epidermis.

The invention discloses a new application of isopentadecanoic acid, and discloses an application of isopentadecanoic acid in preparation of skin care cosmetics, isopentadecanoic acid has the effects of up-regulating expression of hBD-2 and silk protein in human immortalized keratinocytes, reducing expression synthesis of ROS and TRPV1 in the human immortalized keratinocytes, inhibiting release of NO by mouse macrophages, and inhibiting expression of the human immortalized keratinocytes. And the secretion of sebaceous gland cell grease is reduced.