15 results about "Skin Pruritus" patented technology

The present invention provides a novel promoter for lipid synthesis in sebaceous gland cells. By using the novel promoter for lipid synthesis in sebaceous gland cells, a skin barrier damage repairing agent and cosmetics with a skin barrier damage repairing function can be prepared, so that cosmetics for repairing skin barrier damage of at least one type selected from skin dryness, premature skin aging, skin aging, skin pruritus, and senile sebaceous deficiency eczema caused by hypofunction of sebaceous glands and / or reduced sebum secretion can be developed.

This invention discloses a traditional Chinese medicine composition for treating senile pruritus and its preparation method. The composition consists of the following raw materials in parts by weight: Angelica sinensis 15-25 parts, Astragalus membranaceus 12-20 parts, Paeonia lactiflora 10-18 parts, Saposhnikovia divaricata 8-15 parts, Dictamnus dasycarpus 6-12 parts, Kochia scoparia 6-12 parts, Schizonepeta tenuifolia 6-10 parts, Ligusticum chuanxiong 5-10 parts, Ophiopogon japonicus 4-8 parts, and Glycyrrhiza uralensis 3-6 parts. The preparation method includes: raw material pretreatment, water extraction, alcohol extraction, consolidation and concentration, and optional addition of excipients to prepare a bath liquid or powder. This invention is based on the pathogenesis of "deficiency of Qi and blood, blood deficiency and wind dryness," using Angelica sinensis and Astragalus membranaceus as the principal herbs to invigorate Qi and nourish blood to strengthen the body's foundation, and using adjuvant herbs to dispel wind and moisten dryness to treat the symptoms, achieving both symptomatic and root-cause treatment. Comparative experiments have shown that this invention produces unexpected synergistic effects in terms of barrier repair, antipruritic effect, and extraction rate. This invention has a standardized process, is easy to use, and is suitable for widespread application.

The invention discloses an application of a composition of isoliquiritigenin (glycoside), licochalcone and ethnic groups thereof in personal care products, and relates to the technical field of daily chemicals, and the composition is an anti-allergy soothing composition prepared based on a natural plant licorice extract isoliquiritigenin or a glycoside compound isoliquiritigenin thereof, licochalcone A and ethnic groups of licochalcone B, C, D, E and G. The traditional Chinese medicine composition has multiple functions of resisting allergy, relieving, resisting bacteria, diminishing inflammation, improving skin itch and stabbing pain and the like, does not contain hormones and antibiotics, has no toxic or side effect, is mild in effect and non-irritant to skin, can be used for treating skin allergy, red and swollen skin, itch and stabbing pain caused by various reasons, is applied to cosmetics and skin care products, such as gel, cream, masks and facial cleansers, and can be used for treating skin allergy, red and swollen skin, pruritus and stabbing pain caused by various reasons. The skin care product is mild to human bodies, safe and non-irritant, is suitable for sensitive skin, is suitable for people of all ages to use, has strong market competitiveness, and has relatively high economic and social benefits and the like.

The invention relates to an external preparation for treating skin itch of a patient with jaundice and a preparation method of the external preparation, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 25-35 parts of humulus lupulus, 10-20 parts of chionanthus retusus leaves and 10-20 parts of rhizoma tupistrae chinensis. A proper amount of humulus lupulus, chionanthus retusus leaves and rhizoma tupistrae chinensis are matched and used as functional components, and the humulus lupulus, the chionanthus retusus leaves and the rhizoma tupistrae Meanwhile, by combining a gradient decompression reflux extraction mode, effective components are efficiently extracted and fully reserved, so that the improvement effect of the obtained traditional Chinese medicine composition on the skin itch symptom of the jaundice patient is remarkably improved, the treatment effect is superior to that of an existing conventional medicine, a new means is provided for treating the skin itch disease of the jaundice patient, and the application prospect is wide.

The invention provides an external preparation for treating pruritic skin diseases and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The traditional Chinese medicine composition is prepared from the following components: radix sophorae flavescentis, fructus xanthii, flos chrysanthemi indici, fructus cnidii, flos lonicerae, fructus kochiae, radix stemonae and cortex dictamni. The invention also provides a method for preparing an external preparation by using the traditional Chinese medicine composition, and the obtained external preparation is clear in clinical positioning, is suitable for external treatment of eczema, scabies, tinea of feet and hands, dermatitis, skin pruritus and other pruritus skin diseases, has better effects of relieving itching, resisting inflammation and improving skin lesion, and has a wide application prospect. Good clinical application prospects are realized in practical application.

The present invention relates to isolated live bacterial strains of the species Staphylococcus epidermidis selected from the group consisting of the bacteria deposited at the CNCM under deposit numbers I-5688, I-5689, I-5904, I-5691, I-5692, I-5693, I-5694 and I-5695, as well as compositions comprising them. The present invention also relates to the use of such strains for preventing a decline in and / or strengthening the skin barrier function in an individual, for improving skin moisturization, for improving skin quality, in particular the quality of dry skin, for preventing and / or treating cosmetic signs associated with dry skin, in particular selected from tightness, itching, discomfort, a dull complexion, rough skin and pronounced microrelief of the skin, and / or for preventing and / or treating pruritus, in particular pruritus of skin affected by skin disorders, such as atopic dermatitis, and / or for the prevention and / or treatment of atopic dermatitis, as well as to a non-therapeutic cosmetic method for caring for keratinous materials, said non-therapeutic cosmetic method comprising at least one step of topically applying such strains or compositions to said keratinous materials.

This application belongs to the field of traditional Chinese medicine technology, and relates to a traditional Chinese medicine composition for treating pruritus and its preparation method. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of peach kernel, 10-20 parts of forsythia, 12-18 parts of hibiscus bark, 5-15 parts of notopterygium root, 8-13 parts of cinnamon twig, 4-15 parts of scutellaria root, 6-12 parts of pine needle, 1-5 parts of red peony root, 3-8 parts of lily bulb, 7-14 parts of honeysuckle flower, and 2-10 parts of kochia fruit. The preparation method of the traditional Chinese medicine composition includes the following steps: enzymatically hydrolyzing peach kernel, forsythia, hibiscus bark, notopterygium root, cinnamon twig, and scutellaria root, and distilling to obtain volatile oil; pulverizing pine needle, red peony root, lily bulb, honeysuckle flower, and kochia fruit, and sieving to obtain traditional Chinese medicine powder; mixing the traditional Chinese medicine powder, volatile oil, and excipients to obtain the final product. The preparation method of this invention is simple, low-cost, and the obtained traditional Chinese medicine composition has significant therapeutic effects on pruritus, few side effects, and broad market prospects.

The present invention relates to a composition comprising, in a physiologically acceptable medium, at least one of indole-3-lactic acid, indole-3-carboxaldehyde, indole-3-acetic acid, and / or a salt thereof, and at least one adjuvant. The present invention also relates to the use of such a composition for preventing a decline in skin barrier function in an individual and / or for strengthening said skin barrier function, for improving skin moisturization, for improving skin quality, particularly the quality of dry skin, for preventing and / or treating cosmetic signs associated with dry skin, particularly those selected from tightness, itching, discomfort, a dull complexion, rough skin, and pronounced microrelief of the skin, and / or for preventing and / or treating pruritus, particularly pruritus of skin affected by skin disorders such as atopic dermatitis, and / or for preventing and / or treating atopic dermatitis. The present invention also relates to a non-therapeutic cosmetic method for caring for keratinous materials, said non-therapeutic cosmetic method comprising at least one step of topically applying such a composition to said keratinous materials.

The present invention relates to an isolated live bacterial strain of the species Staphylococcus epidermidis selected from the group consisting of bacteria preserved in CNCM according to search numbers I-5688, I-5689, I-5904, I-5691, I-5692, I-5693, I-5694 and I-5695, and compositions comprising the same. The invention also relates to the use of such a strain for preventing and / or enhancing skin barrier function in an individual, for improving skin moisturizing, for improving skin quality, in particular quality of dry skin, for preventing and / or treating cosmetic signs associated with dry skin, in particular for preventing and / or treating cosmetic signs associated with dry skin. The present invention relates to a cosmetic composition comprising cosmetic signs, in particular selected from the group consisting of tension, pruritus, uncomfortable feelings, blurred complexion, pruritus, and significant slight undulation of the skin, and / or for the prevention and / or treatment of pruritus, in particular skin pruritus affected by dermatological conditions such as atopic dermatitis, and / or for the prevention and / or treatment of atopic dermatitis, and a non-therapeutic cosmetic process for caring for a keratin material comprising at least one step of topically applying such a strain or composition to said keratin material.

The present invention discloses a traditional Chinese medicine composition with soothing and anti-allergic effects, as well as its preparation method and application. The composition comprises a Sophora flavescens extract, a Phellodendron amurense extract, and a Monkey Ear Ring extract in a mass ratio of (2-4):(1-2):(0.5-1). The composition significantly inhibits hyaluronidase activity, with an inhibition rate exceeding 67.68%. It can also rapidly relieve yam juice-induced skin pruritus within 5.5 minutes, with an antipruritic effect duration 26.5% shorter than that of the positive control group. This composition achieves a "fast antipruritic and strong soothing" effect through multi-target synergistic action, and its efficacy is significantly superior to that of single components and two-component combinations. Skin irritation experiments have verified that the composition has no allergic risk. The present invention solves the technical problems of existing chemical anti-allergic agents with high irritation and natural ingredients with limited efficacy. It can be widely used in cosmetic dosage forms such as creams and essences, providing an innovative solution for the development of safe and effective natural anti-allergic products.

The present application provides a kind of composition, preparation and its preparation method and purposes for treating skin pruritus.The composition for treating skin pruritus is composed of hydrocarbon halide and / or hydrocarbon.The hydrocarbon halide is one, two or more than three combinations of difluoromonochloromethane, difluoromethane, trifluoromonochloromethane, tetrafluoromethane, dichlorotrifluoroethane, difluoroethane, monochlorodifluoroethane, tetrafluoroethane, hexafluoroethane, chloroethane, pentafluoropropane and / or octafluoropropane.The hydrocarbon is one, two or more than three combinations of methane, ethane, propane, butane, cycloethane, cyclopropane and / or cyclobutane.The composition or preparation of the present application has excellent effects when used as a drug for treating skin pruritus, such as relieving pruritus symptoms quickly, reducing the risk of infection, shortening the course of the disease and reducing the economic burden of patients.

The present invention relates to a composition comprising, in a physiologically acceptable medium: at least indole-3-lactic acid; an indole-3-formaldehyde compound; indole-3-acetic acid; and / or one of their salts; and at least one adjuvant. It also relates to such a composition for use in preventing a reduction in and / or enhancing a skin barrier function in an individual, for improving skin moisturizing, for improving the quality of skin, in particular dry skin, for preventing and / or treating cosmetic manifestations associated with dry skin, and for preventing and / or treating cosmetic manifestations associated with dry skin. Said cosmetic exhibits, in particular, a sensation selected from the group consisting of tension, pruritus, uncomfortable feelings, blurred complexion, pruritus, and significant slight undulation of the skin, and / or for the prevention and / or treatment of pruritus, in particular skin pruritus affected by dermatological conditions such as atopic dermatitis, and / or for the prevention and / or treatment of atopic dermatitis. The invention also relates to a non-therapeutic cosmetic process for caring for a keratin material, comprising at least one step of topically applying such a composition to said keratin material.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or skin pruritus, and more specifically to a pharmaceutical composition for preventing or treating allergic skin diseases or skin pruritus, which contains ABT-751 or TN-16 as an active ingredient; a cosmetic composition for preventing or ameliorating allergic skin diseases or skin pruritus, which contains ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for moisturizing the skin, which contains ABT-751 or TN-16 as an active ingredient. It has been confirmed that the composition for preventing, ameliorating, and treating atopic dermatitis according to the present invention effectively increases filaggrin expression in skin cells and improves skin barrier function, thereby effectively improving or treating the symptoms of allergic skin diseases including atopic dermatitis or skin pruritus, and also exhibits excellent skin moisturizing effects.