External liquid traditional Chinese medicine preparation for skin pruritus caused by eczema and urticaria

Abstract

The invention provides an external liquid traditional Chinese medicine preparation for skin pruritus caused by eczema and urticaria, and relates to the field of traditional Chinese medicines. The external liquid traditional Chinese medicine preparation for skin pruritus caused by eczema and urticaria is prepared from the following raw materials in parts by weight: 0-15 parts of belvedere fruit, 0-15 parts of honeysuckle, 0-15 parts of divaricate saposhnikovia root, 0-15 parts of Chinese thorowax root extract and 100 parts of special water. The traditional Chinese medicine composition is prepared from the raw materials of the traditional Chinese medicine composition, has the characteristics of easily available raw materials, simple process, low cost and high efficiency, is beneficial to pharmaceutical production and quality control of pharmaceutical enterprises, is low in product price and easy to accept by patients, and has the effects of clearing away heat and toxic materials, inhibiting bacteria, diminishing inflammation, relieving itching and the like through mutual cooperation and coordination of the raw materials; the traditional Chinese medicine has a good curative effect on eczema and urticaria.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an external liquid traditional Chinese medicine preparation for skin itching caused by eczema and urticaria. Background Art

[0002] Eczema: Eczema is a skin inflammatory reaction with severe itching caused by a variety of internal and external factors. The incidence of eczema is about 10% to 20%, and the incidence in adults is about 1% to 3%. Eczema usually starts in infancy, before the age of 5, and some patients may persist for a lifetime; Urticaria: The cause of urticaria is very complicated, and about 3 / 4 of patients cannot find the cause, especially chronic urticaria. Common causes include: food and food additives, inhalants, infection, drugs, physical factors such as mechanical stimulation, cold and heat, sunlight, insect bites, mental factors and endocrine changes, genetic factors, etc.

[0003] At present, Western medicine for treating urticaria mainly uses ketotifen, chlorpheniramine, cyproheptadine, cetirizine, loratadine and other antihistamines or glucocorticoids to treat urticaria, and the drugs for treating eczema are mainly topical drugs and oral drugs. Topical drugs mainly include hormone creams, such as mometasone furoate cream, hydrocortisone butyrate cream, etc., and oral drugs are mainly antihistamines, such as loratadine and cetirizine. Antihistamines and hormone drugs are prone to more serious adverse reactions. Many topical ointments are generally effective. It is difficult for many patients to quickly curb the itching condition, and it is easy to relapse. Therefore, those skilled in the art provide a topical liquid Chinese medicine preparation for eczema and urticaria skin itching to solve the problems raised in the above background technology. Summary of the invention

[0004] 1. Technical issues to be solved

[0005] In view of the deficiencies in the prior art, the present invention provides an external liquid Chinese medicine preparation for eczema and urticaria skin itching, which solves the problem that current therapeutic drugs are prone to more serious adverse reactions and recurrence.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical scheme: an external liquid Chinese medicine preparation for skin itching caused by eczema and urticaria, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0008] Preferably, it is made from the following raw materials in parts by weight: 0-15 parts by weight of Kochia scoparia, 0-15 parts by weight of honeysuckle, 0-15 parts by weight of siler, 0-15 parts by weight of radix siler, 0-15 parts by weight of bupleurum and 100 parts of special water, and the specific extraction steps are as follows:

[0009] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0010] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0011] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0012] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0013] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0014] Preferably, the special water is low nuclear magnetic small molecule water that is easily absorbed by cells and is formed by calcining medical stone, ginger stone and rare earth at high temperature, and the half-width peak of oxygen 17 in the water is less than 80 Hz.

[0015] Preferably, the Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0016] (III) Beneficial effects

[0017] The present invention provides a liquid Chinese medicine preparation for external use for treating eczema and urticaria skin itching. It has the following beneficial effects:

[0018] 1. The present invention is made of traditional Chinese herbal medicines, which are combined in an orderly manner to form an external liquid Chinese medicine preparation that is effective in treating itching. It can be bottled and sprayed on the patient's skin surface. It has the characteristics of being less likely to relapse for the itching caused by eczema and urticaria, being safe and reliable, and having no toxic side effects.

[0019] 2. In the present invention, the raw materials of the Chinese medicine composition are adopted, which has the characteristics of easy availability of raw materials, simple process, low cost and high efficiency, which is beneficial to pharmaceutical companies to carry out drug production and quality control, and the product price is low and easily accepted by patients. DETAILED DESCRIPTION

[0020] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0021] Embodiment 1:

[0022] The embodiment of the present invention provides an external liquid Chinese medicine preparation for treating eczema and urticaria skin itching, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0023] The invention is prepared from the following raw materials in parts by weight: extracts of 1 part by weight of Kochia scoparia, 10 parts by weight of honeysuckle, 2 parts by weight of Saposhnikovia divaricata, 3 parts by weight of bupleurum and 100 parts of special water, and the liquid preparation is filtered after soaking for three days. The specific extraction steps are as follows:

[0024] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0025] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0026] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0027] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0028] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0029] Special water is made from medical stone, ginger stone and rare earth stone which are fired at high temperature to form low nuclear magnetic small molecule water that is easily absorbed by cells. The half-width peak of oxygen 17 in water is less than 80Hz.

[0030] The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0031] Embodiment 2:

[0032] A liquid Chinese medicinal preparation for external use for treating itchy skin caused by eczema and urticaria, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0033] The preparation is made from the following raw materials in parts by weight: extracts of 1 part by weight of Kochia scoparia, 1 part by weight of honeysuckle, 1 part by weight of Saposhnikovia divaricata, 1 part by weight of Bupleurum chinense and 100 parts of special water, and the liquid preparation is filtered after soaking for three days. The specific extraction steps are as follows:

[0034] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0035] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0036] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0037] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0038] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0039] Special water is made from medical stone, ginger stone and rare earth stone which are fired at high temperature to form low nuclear magnetic small molecule water that is easily absorbed by cells. The half-width peak of oxygen 17 in water is less than 80Hz.

[0040] The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0041] Embodiment three:

[0042] A liquid Chinese medicinal preparation for external use for treating itchy skin caused by eczema and urticaria, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0043] The preparation is made from the following raw materials in parts by weight: extracts of 10 parts by weight of Kochia scoparia, 10 parts by weight of honeysuckle, 10 parts by weight of Saposhnikovia divaricata, 10 parts by weight of bupleurum and 100 parts of special water, and the liquid preparation is filtered after soaking for three days. The specific extraction steps are as follows:

[0044] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0045] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0046] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0047] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0048] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0049] Special water is made from medical stone, ginger stone and rare earth stone which are fired at high temperature to form low nuclear magnetic small molecule water that is easily absorbed by cells. The half-width peak of oxygen 17 in water is less than 80Hz.

[0050] The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0051] Embodiment 4:

[0052] A liquid Chinese medicinal preparation for external use for treating itchy skin caused by eczema and urticaria, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0053] The preparation is made from the following raw materials in parts by weight: extracts of 15 parts by weight of Kochia scoparia, 15 parts by weight of honeysuckle, 15 parts by weight of Saposhnikovia divaricata, 15 parts by weight of bupleurum and 100 parts of special water. The liquid preparation is filtered after soaking for three days. The specific extraction steps are as follows:

[0054] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0055] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0056] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0057] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0058] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0059] Special water is made from medical stone, ginger stone and rare earth stone which are fired at high temperature to form low nuclear magnetic small molecule water that is easily absorbed by cells. The half-width peak of oxygen 17 in water is less than 80Hz.

[0060] The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0061] Embodiment five:

[0062] A liquid Chinese medicinal preparation for external use for treating itchy skin caused by eczema and urticaria, comprising the following raw materials: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

[0063] The invention is prepared from the following raw materials in parts by weight: 5 parts by weight of Kochia scoparia, 10 parts by weight of honeysuckle, 5 parts by weight of Saposhnikovia divaricata, 10 parts by weight of bupleurum and 100 parts of special water, and the liquid preparation is filtered after soaking for three days. The specific extraction steps are as follows:

[0064] S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients;

[0065] S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined;

[0066] S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract;

[0067] S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature;

[0068] S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

[0069] Special water is made from medical stone, ginger stone and rare earth stone which are fired at high temperature to form low nuclear magnetic small molecule water that is easily absorbed by cells. The half-width peak of oxygen 17 in water is less than 80Hz.

[0070] The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.

[0071] Among them: Kochia seeds have the functions of clearing away heat and dampness, dispelling wind and relieving itching;

[0072] Honeysuckle is sweet and cold in nature, aromatic in smell, and can clear away heat without hurting the stomach. Its aromatic fragrance can also dispel pathogens, and can be used for various febrile diseases, such as fever, rash, spots, heat-toxic sores, sore throat, etc. Honeysuckle has the effects of dispersing wind-heat, clearing away heat and detoxifying.

[0073] Saposhnikovia root: pungent, sweet, warm, has the functions of dispelling wind, removing dampness, and stopping spasms, and has the effects of treating rheumatic pain, rashes and itching;

[0074] Bupleurum: Nature and flavor: slightly cold, bitter, pungent, enters the liver meridian and gallbladder meridian, has the effects of soothing the liver and gallbladder, soothing qi and relieving depression, and dispersing fire. Function: Mainly penetrate the surface to release heat, soothe the liver and relieve depression, and raise Yang Qi.

[0075] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A liquid Chinese medicine preparation for external use for treating eczema and urticaria, characterized in that: Including the following ingredients: Kochia scoparia, honeysuckle, siler, bupleurum and special water.

2. A liquid Chinese medicine preparation for external use for treating eczema and urticaria according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: extracts of Kochia scoparia seeds 0-15 parts by weight, honeysuckle flowers 0-15 parts by weight, siler leaves 0-15 parts by weight, bupleurum 0-15 parts by weight, and 100 parts of special water. The specific extraction steps are as follows: S1. Prepare the medicinal materials, rinse the Kochia scoparia, honeysuckle, Saposhnikovia divaricata and Bupleurum chinense with clean water, clean the dirt and impurities on the surface of the medicinal materials, cut the medicinal materials into pieces of appropriate size or crush them into coarse powder to facilitate the extraction of effective ingredients; S2. Extraction: extract the medicinal materials by water extraction. First, put the prepared medicinal materials into an extraction container, add an appropriate amount of water inside, soak for 4 hours to one night, so that the medicinal materials can fully absorb water and swell. Then, heat the soaked medicinal materials to boiling, and then keep boiling for 1 to 2 hours to extract the effective ingredients. In order to improve the extraction efficiency, multiple extractions can be performed and the extracts are combined; S3. Filtration: After the extraction is completed, use filter cloth or filter paper to perform coarse filtration to remove the medicinal material residue, and then finely filter the extract after coarse filtration. A microporous filter membrane or other fine filtration equipment can be used to obtain a clear extract; S4. Concentrate, put the filtered extract into a rotary evaporator, heat and evaporate under reduced pressure to remove the solvent and concentrate the extract. In order to protect heat-sensitive components, the concentration process is carried out at a relatively low temperature; S5. Drying: freeze the concentrate and then sublimate the water under vacuum conditions to obtain a dry extract by using freeze-drying technology.

3. The external liquid Chinese medicine preparation for eczema and urticaria skin itching according to claim 1, characterized in that: The special water is a low-nuclear magnetic small-molecule water that is easily absorbed by cells and is prepared by high-temperature calcination of medical stone, ginger stone and rare earth. The half-width peak of oxygen 17 in the water is less than 80 Hz.

4. The external liquid Chinese medicine preparation for eczema and urticaria skin itching according to claim 1, characterized in that: The Chinese medicine composition according to any one of claims 1 or 3 is a liquid external preparation.