Application of composition of isoliquiritigenin (glycoside), licochalcone and ethnic group thereof in personal care products

Abstract

The invention discloses an application of a composition of isoliquiritigenin (glycoside), licochalcone and ethnic groups thereof in personal care products, and relates to the technical field of daily chemicals, and the composition is an anti-allergy soothing composition prepared based on a natural plant licorice extract isoliquiritigenin or a glycoside compound isoliquiritigenin thereof, licochalcone A and ethnic groups of licochalcone B, C, D, E and G. The traditional Chinese medicine composition has multiple functions of resisting allergy, relieving, resisting bacteria, diminishing inflammation, improving skin itch and stabbing pain and the like, does not contain hormones and antibiotics, has no toxic or side effect, is mild in effect and non-irritant to skin, can be used for treating skin allergy, red and swollen skin, itch and stabbing pain caused by various reasons, is applied to cosmetics and skin care products, such as gel, cream, masks and facial cleansers, and can be used for treating skin allergy, red and swollen skin, pruritus and stabbing pain caused by various reasons. The skin care product is mild to human bodies, safe and non-irritant, is suitable for sensitive skin, is suitable for people of all ages to use, has strong market competitiveness, and has relatively high economic and social benefits and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemicals, in particular to a cosmetic raw material, and specifically to the application of a composition of isoliquiritigenin (glycoside) and licochalcone and a group thereof in personal care products. Background Art

[0002] The skin is the largest organ in the human body, in direct contact with the external environment. It protects, eliminates waste, regulates body temperature, and senses external stimuli. Skin health has a crucial impact on human well-being. The health of exposed skin, such as the face and hands, directly reflects a person's mental state and how others perceive them. With the accelerated pace of life, increased work pressure, and changes in dietary patterns, the number of people suffering from allergies is rapidly increasing.

[0003] Natural extracts are generally mildly irritating, making them a valuable resource for treating sensitive skin. Traditional Chinese Medicine (TCM) posits that "skin-based treatments" are based on the principle of "treating skin with skin." Skin-based treatments penetrate the skin, reaching the affected area and providing a beautifying effect. For example, poplar bark, magnolia bark, and pomegranate bark are commonly used in TCM for skin conditioning.

[0004] Isoliquiritigenin, a flavonoid extracted from licorice, inhibits tyrosinase, a key enzyme in melanin synthesis, contributing to skin whitening. Furthermore, by regulating the TLR4 / NF-kB signaling pathway, it reduces the release of inflammatory factors, exerting anti-allergic and soothing effects. It can be used to relieve itching, redness, and swelling.

[0005] Isoliquiritin is a flavonoid glycoside compound derived from the genus Glycyrrhiza in the Leguminosae family. Its chemical structure is composed of isoliquiritigenin as the aglycone, connected to glucose groups via glycosidic bonds. This ingredient has multiple biological activities: in terms of antioxidant activity, it can scavenge reactive oxygen species (ROS) such as hydroxyl free radicals and superoxide anions, inhibit lipid peroxidation, and reduce oxidative stress damage to cells; in terms of anti-inflammatory and soothing effects, it can alleviate skin inflammatory reactions by inhibiting the release of inflammatory mediators such as TNF-α and IL-6, downregulating the activity of cyclooxygenase (COX) and lipoxygenase (LOX); in terms of whitening and regulating, it can inhibit tyrosinase activity and regulate melanosome transport, reducing epidermal pigmentation. Due to its high safety, isoliquiritin is often used as a functional ingredient in antioxidant, soothing and repairing, and whitening and spot-lightening products.

[0006] Licorice chalcone A and its subgroups, Licorice chalcone B, C, D, E, and G, are derived from the natural plant licorice and belong to the flavonoid class. Compared to other flavonoids, chalcone has the advantages of low toxicity and non-mutagenicity. It is an effective anti-allergic and anti-inflammatory active ingredient in licorice and is often used in cosmetic products. Pharmacological studies have confirmed that it can inhibit tyrosinase activity to reduce melanin biosynthesis, exerting a whitening and freckle-removing effect. At the same time, this ingredient has both anti-inflammatory and soothing activities, can reduce skin inflammatory reactions, improve facial flushing and capillary dilation (redness), and inhibit the formation of acne and blackheads associated with Propionibacterium acnes. In addition, chalcone has antibacterial, antioxidant, and moisturizing effects.

[0007] There are some allergy-relieving products on the market. Most of these products only offer soothing and antipruritic properties. Their diverse and complex raw materials, combined with a single efficacy, fail to meet consumer needs. Furthermore, the extraction process is complex and the equipment is expensive. None of these inventions have been tested for safety, posing a certain risk.

[0008] Therefore, it is of great practical significance to develop a natural extract composition that is more convenient to use and has a better improvement effect on the skin. Summary of the Invention

[0009] To overcome the deficiencies in the background art, the present invention provides an application of a composition of isoliquiritigenin (glycoside) and licorice chalcone and its family in personal care products. The composition utilizes isoliquiritigenin and its glycoside compound isoliquiritigenin, licorice chalcone A and its family licorice chalcone B, C, D, E, and G. Through synergistic action, the composition has the significant effects of soothing sensitivity, calming and relieving itching, removing redness and swelling, and repairing after allergic reactions. In addition, the plant composition of the present invention is safe and non-irritating and can be used in skin care products.

[0010] In order to achieve the above-mentioned purpose of the invention, the present invention adopts the following technical solution:

[0011] The invention discloses an application of a composition of isoliquiritigenin (glycoside) and licorice chalcone and its family in personal care products. The composition is added to a facial mask, essence, gel, skin care ointment, face cream, or sunscreen personal care product at a concentration of 0.005% to 10% (w / w). The components of the composition include isoliquiritigenin or its glycoside compound isoliquiritigenin, licorice chalcone A and its family of licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G, or any combination of two or more thereof. The isoliquiritigenin or its glycoside compound isoliquiritigenin accounts for 1 to 99% of the total weight of the composition by weight, and the licorice chalcone A and its family of licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G accounts for 1 to 99% of the total weight of the composition by weight.

[0012] The composition of isoliquiritigenin (glycoside) and licorice chalcone and its group is used in personal care products, and the weight ratio of the isoliquiritigenin or its glycoside compound isoliquiritigenin to licorice chalcone A and its group of licorice chalcone B or licorice chalcone C or licorice chalcone D or licorice chalcone E or licorice chalcone G is 1:99 to 99:1.

[0013] The isoliquiritigenin (glycoside) and licorice chalcone and their group compositions are used in personal care products. The raw material purity of the isoliquiritigenin or its glycoside compound isoliquiritigenin is 5-99.99%.

[0014] The composition of isoliquiritigenin (glycoside) and licochalcone and its group is used in personal care products. The raw material purity of licochalcone B, licochalcone C, licochalcone D, licochalcone E or licochalcone G in the licochalcone A and its group is 5-99.99%.

[0015] By adopting the above technical solution, the present invention has the following advantages:

[0016] The components of the present invention are an anti-allergic and soothing composition made from isoliquiritigenin, a natural plant licorice extract, or its glycoside compound isoliquiritin, and licorice chalcone A and its group licorice chalcone B, C, D, E, and G. The composition has multiple functions such as anti-allergic and soothing, antibacterial and anti-inflammatory, and improvement of skin itching and stinging. At the same time, the composition does not contain hormones and antibiotics, has no toxic side effects, has a mild effect, and is non-irritating to the skin. It can be used to treat skin allergies, redness, swelling, itching, and stinging caused by various reasons. It can be used in cosmetics and skin care products such as gels, creams, facial masks, facial cleansers, etc. It is gentler on the human body, safer and non-irritating, suitable for sensitive skin, and suitable for people of all ages. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is the inhibition rate of the anti-allergic soothing composition on TRPV1 receptor activity in a specific embodiment of the present invention;

[0018] Figure 2 It is the inhibition rate of hyaluronidase in vitro by the anti-allergic soothing composition in a specific embodiment of the present invention. DETAILED DESCRIPTION

[0019] The present invention can be explained in more detail by the following examples, but the present invention is not limited to the following examples;

[0020] The present invention discloses an application of a composition of isoliquiritigenin (glycoside) and licorice chalcone and its family in personal care products. The composition is added to a facial mask, essence, gel, skin care cream, face cream, or sunscreen personal care product at a concentration of 0.005% to 10% (w / w). The composition comprises isoliquiritigenin or its glycoside compound isoliquiritigenin, licorice chalcone A and its family of licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G, or any combination of two or more thereof. The isoliquiritigenin or its glycoside compound isoliquiritigenin accounts for 1 to 99% of the total weight of the composition by weight, and the licorice chalcone A and its family of licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G accounts for 1 to 99% of the total weight of the composition by weight.

[0021] During implementation, the weight ratio of the isoliquiritigenin or its glycoside compound isoliquiritin to licorice chalcone A and licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E or licorice chalcone G in the group thereof is 1:99 to 99:1.

[0022] Furthermore, the raw material purity of the isoliquiritigenin or its glycoside compound isoliquiritigenin is 5 to 99.99%.

[0023] Furthermore, the raw material purity of the licorice chalcone A and licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E or licorice chalcone G in the group thereof is 5 to 99.99%.

[0024] In the embodiments of the present invention, isoliquiritigenin and its glycoside compound isoliquiritin and chalcone (A, B, C, D, E, G) are prepared using existing technology equipment, and other cosmetic excipients are all commercially available products.

[0025] Element percentage(%) Isoliquiritigenin or its glycoside compound isoliquiritigenin 54 Chalcone (A, B, C, D, E, G) 46

[0026] (1) placing a plant extract containing isoliquiritigenin or its glycoside compound isoliquiritigenin and chalcone (A, B, C, D, E, G) in an oven at 40-60° C. for 12-36 hours until the extract is completely dried;

[0027] (2) Weighing a plant extract containing isoliquiritigenin and its glycoside compound isoliquiritin and chalcone (A, B, C, D, E, G) in proportion, placing it in a grinder, grinding it for 15 to 30 minutes, and then passing it through a 60-100 mesh sieve after it is completely ground;

[0028] (3) placing the sieved extract into a mixer and mixing for 1 to 2 hours to obtain a composition containing a natural plant extract;

[0029] (4) Store in a dry place.

[0030] The present invention has the following application embodiments:

[0031] The acne-removing composition particles prepared by the present invention are added to polyol for dissolution, and cosmetic excipients are added at the same time, and the composition can be applied to anti-inflammatory and acne-removing cosmetics and skin care products.

[0032] Commonly used excipients in cosmetics are one or more of solubilizers, surfactants, emulsifiers, thickeners, humectants, preservatives, emollients, pH regulators and fragrances.

[0033] The solubilizing agent in this embodiment is selected from one or two of ethanol, ethylene glycol, propylene glycol, glycerol, butylene glycol, pentanediol, and hexylene glycol.

[0034] The surfactants described in this embodiment are selected from at least two of coconut oil monoethanolamide, coconut oil diethanolamide, monolauryl phosphate, and disodium lauryl iminodiacetate.

[0035] The emulsifier in this embodiment is selected from one or two of cetearyl glucoside, PEG-100 stearate, and cetearyl alcohol.

[0036] The thickener in this embodiment is selected from one or two of carbomer, hydroxyethyl cellulose, xanthan gum, sodium alginate, and ammonium acryloyldimethyltaurate.

[0037] The moisturizing agent in this embodiment is at least one of propylene glycol, butylene glycol, allantoin, polyglutamic acid, and glycerin.

[0038] The chelating agent described in this embodiment is selected from disodium EDTA.

[0039] The preservatives in this embodiment are at least two selected from benzyl alcohol, methylchloroisothiazolinone, and methylisothiazolinone.

[0040] The emollient in this embodiment is selected from at least one of jojoba oil, cyclopolydimethylsiloxane, polydimethylsiloxane, and glyceryl stearate.

[0041] The pH regulator in this embodiment is selected from aminomethyl propanol and triethanolamine.

[0042] The spices described in this embodiment are selected from any one of essences and essential oils.

[0043] Example 1 Gel containing the natural plant extract composition of the present invention

[0044] The gel containing the natural plant extract composition of the present invention in Example 1 of the present invention comprises the following raw materials, calculated by mass percentage:

[0045]

[0046] Preparation method:

[0047] S1: Place the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritigenin and chalcone (A, B, C, D, E, G) in an oven at 50°C for 24 hours until the extract is completely dried;

[0048] S2: Put the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritin and chalcone (A, B, C, D, E, G) in a ratio of 55:45 into a grinder, grind for 20 minutes, and then pass through a 100-mesh sieve after being completely ground;

[0049] S3: putting the sieved powder into a mixer and mixing for 2 hours to obtain a natural plant extract composition, and then obtaining a natural plant anti-allergic soothing composition C;

[0050] S4: Add water to phase A to disperse and swell. After swelling is complete, add it to the emulsifier together with phase B. Heat and stir at 85℃ to dissolve completely. Keep warm for 20 minutes, then defoam and cool down.

[0051] S5: Dissolve phase D in water. When the temperature drops to 45°C, add the mixture of phases A and B into phase D and stir evenly to obtain a mixed solution.

[0052] S6: When the temperature drops to about 37°C, add phase C to the mixed solution in S6 and stir evenly. Then add phase E and mix evenly. After the plate is aligned and qualified, discharge the material to obtain a gel containing the natural plant extract composition of the present invention.

[0053] Example 2 Facial mask containing the natural plant extract composition of the present invention

[0054] The facial mask containing the natural plant extract composition of the present invention in Example 2 of the present invention comprises the following raw materials, calculated by mass percentage:

[0055]

[0056] Preparation method:

[0057] S1: Place the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritigenin and chalcone (A, B, C, D, E, G) in an oven at 45°C for 24 hours until the extract is completely dried;

[0058] S2: Place the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritin and chalcone (A, B, C, D, E, G) in a ratio of 60:40 into a grinder, grind for 15 minutes, and then pass through an 80-mesh sieve after complete grinding;

[0059] S3: placing the sieved powder into a mixer and mixing for 1.5 hours to obtain a composition containing natural plant extracts, thereby obtaining a natural plant anti-allergic soothing composition C;

[0060] S4: Place phase A in a homogenizer, heat to 85°C and homogenize for 5 minutes to completely dissolve it; add phase B to phase A and stir to dissolve, keep warm for 30 minutes and then start cooling;

[0061] S5: When the temperature drops to about 40°C, add phase C and stir evenly;

[0062] S6: When the temperature drops to about 35°C, add phase D, stir evenly, and discharge the material after it passes the plate alignment to obtain a facial mask liquid containing the natural plant extract composition of the present invention;

[0063] S7: Soaking the facial mask paper in the facial mask liquid described in S7 to prepare a facial mask containing the natural plant extract composition of the present invention.

[0064] Example 3 Anti-allergic soothing skin cream containing the natural plant extract composition of the present invention

[0065] Example 3 of the present invention is an anti-allergic and soothing skin care cream containing the natural plant extract composition of the present invention, which comprises the following raw materials by mass percentage:

[0066]

[0067]

[0068] Preparation method:

[0069] S1: Place the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritigenin and chalcone (A, B, C, D, E, G) in an oven at 50°C for 18 hours until the extract is completely dried;

[0070] S2: Place the plant extract containing isoliquiritigenin or its glycoside compound isoliquiritigenin and chalcone (A, B, C, D, E, G) in a ratio of 54:46 into a grinder, grind for 20 minutes, and then pass through an 80-mesh sieve after complete grinding;

[0071] S3: putting the sieved powder into a mixer and mixing for 1 hour to obtain a natural plant anti-allergic soothing composition;

[0072] S4 dissolving the anti-allergic soothing composition in butylene glycol to obtain C;

[0073] S5: Heat phase A and phase B to 85°C separately to completely dissolve them and keep warm for 30 minutes;

[0074] S6: Add phase B to phase A and stir thoroughly to mix evenly;

[0075] S7: When the temperature drops to about 65°C, add B2 and keep warm for 30 minutes;

[0076] S8: When the temperature drops to about 45° C., add phase C and stir evenly to obtain an anti-allergic and soothing skin care cream containing the natural plant extract composition of the present invention.

[0077] Comparative Examples 1 to 4

[0078] The skin care creams of Comparative Examples 1 to 4 comprise the following raw materials, calculated by mass percentage:

[0079]

[0080]

[0081] The preparation method is similar to that of Example 3.

[0082] The gels of Comparative Examples 5 to 8 comprise the following raw materials, calculated by mass percentage:

[0083]

[0084]

[0085] The preparation method is similar to that of Example 1.

[0086] Test Example 1: Inhibition of TRPV1 receptor activity by the anti-allergic soothing composition of the present invention

[0087] Cell model construction:

[0088] (1) Experimental cell selection: The TRPV1-HACT cell model was selected for this experiment because it has high expression of TRPV1, which facilitates signal detection.

[0089] (2) Culture conditions: 37°C, 5% CO2, DMEM medium containing 10% FBS.

[0090] Drug treatment and grouping:

[0091] (1) Concentration of anti-allergic soothing composition: 0.002% (M / V).

[0092] (2) Control group setting: Positive activation group (2% capsaicin)

[0093] TRPV1 functional assay:

[0094] (1) Calcium ion fluorescence method (rapid screening)

[0095] Probe loading: Fluo-4 AM (2 μM) incubated for 30 minutes.

[0096] Stimulation conditions: Chemical activation: pH 5.0 buffer.

[0097] Data collection: The fluorescence intensity (Ex / Em=488 / 525 nm) was recorded by a microplate reader, and the ΔF / F0 peak inhibition rate was calculated.

[0098] (2) Patch clamp technique (mechanism verification)

[0099] Whole-cell recordings were performed in voltage clamp mode (-60 mV) to observe the inhibitory effect of chalcone on capsaicin-induced currents.

[0100] Molecular mechanism expansion:

[0101] (1) TRPV1 protein expression: Western Blot was used to detect changes in TRPV1 protein levels after chalcone treatment.

[0102] (2) Association with inflammatory factors: ELISA was used to detect the release of inflammatory factors such as IL-6, and to analyze whether chalcone indirectly regulates TRPV1 by inhibiting IL-6.

[0103] Calculation of inhibition rate:

[0104]

[0105] Positive result criteria: inhibition rate > 50% and significant dose dependence

[0106] The inhibitory effect of the anti-allergic soothing compositions of Examples 1 and 3 and Comparative Examples 1 to 8 on hyaluronidase in vitro is detailed in Figure 1 Taking Comparative Examples 1 and 5 as controls, the anti-allergic soothing composition of Example 1 has the highest inhibition rate on TRPV1 receptor activity, that is, the anti-allergic soothing composition of Example 1 has the highest anti-allergic efficacy.

[0107] Test Example 2 In vitro hyaluronidase inhibition experiment of the anti-allergic soothing composition of the present invention.

[0108] Preparation of experimental reagents:

[0109] (1) Acetate buffer solution (pH = 5.6): Measure 1155 μL of glacial acetic acid, dilute to 100 mL, mix thoroughly, and take 4.8 mL of it as solution A. Weigh 2.72 g of sodium acetate crystals, dissolve in water, and dilute to 100 mL, mix thoroughly, and take 45.2 mL of it as solution B. Mix solutions A and B, dilute to 100 mL with water, and mix thoroughly. Accurately measure the pH value and adjust to 5.6 with solution A or B.

[0110] (2) Hyaluronidase solution: Weigh 0.0100 g of hyaluronidase into a beaker and add 4 mL of acetate buffer solution to a final working concentration of 1250 u / mL.

[0111] (3) 0.5 mg / mL sodium hyaluronate solution: Weigh 0.0050 g of sodium hyaluronate into a beaker and add 10 mL of acetic acid buffer solution.

[0112] (4) Ehrlich reagent: Weigh 0.8 g of p-dimethylaminobenzaldehyde and dissolve it in 15 mL of concentrated hydrochloric acid and 15 mL of anhydrous ethanol. It can be stored for two months.

[0113] (5) Acetylacetone solution: Dissolve 3.5 mL of acetylacetone in 50 mL of 1.0 mol / L sodium carbonate solution. Prepare this solution before use.

[0114] Experimental methods:

[0115] The hyaluronidase in vitro inhibition test was conducted using the Elson-Morgan method. 0.1 mL of 0.25 mmol / L CaCl2 solution and 0.5 mL of hyaluronidase solution were incubated at 37°C for 20 minutes. 0.5 mL of the anti-allergic soothing composition prepared in Examples 1 and 3 and Comparative Examples 1-8 was added, and the mixture was incubated at 37°C for another 20 minutes. 0.5 mL of sodium hyaluronate solution was added, incubated at 37°C for 30 minutes, and then allowed to stand at room temperature for 5 minutes. 0.1 mL of 0.4 mol / L NaOH solution and 0.5 mL of acetylacetone solution were added, and the mixture was heated in a boiling water bath for 15 minutes, followed by immediate cooling with ice water for 5 minutes. 1.0 mL of Ehrlich reagent was added and diluted with 3.0 mL of anhydrous ethanol. The mixture was allowed to stand for 20 minutes for color development, and the absorbance was measured using a spectrophotometer.

[0116] Anti-allergic activity calculation formula:

[0117]

[0118] Where: A——ABS value of control solution (using acetate buffer solution instead of sample solution)

[0119] B——ABS value of blank solution (using acetate buffer solution instead of sample solution and enzyme solution)

[0120] C——ABS value of sample solution

[0121] D - ABS value of sample blank solution (acetic acid buffer solution is used instead of enzyme solution). During the experiment, the wavelength of group A samples is first scanned in the range of 450-700nm to determine the maximum absorption wavelength. Then, deionized water is used as a reference and the ABS value is measured at the maximum absorption wavelength.

[0122] The difference between two measured values ​​of the same anti-allergic soothing composition should not exceed 10% of the average value of the two measurements.

[0123] The inhibitory effect of the anti-allergic soothing compositions of Examples 1 and 3 and Comparative Examples 1 to 8 on hyaluronidase in vitro is detailed in Figure 2 Taking Comparative Examples 1 and 5 as controls, the anti-allergic soothing composition of Example 1 has the highest in vitro inhibition rate of hyaluronidase, that is, the anti-allergic soothing composition of Example 1 has the highest anti-allergic efficacy.

[0124] Test Example 3 Anti-inflammatory experiment of the anti-allergic soothing composition of the present invention.

[0125] A mouse ear sensitization inflammation model was induced by applying xylene. Male mice weighing 20 to 28 g were selected and randomly divided into 11 groups, with 15 mice in each group. The samples prepared in Examples 1 and 3, and Comparative Examples 1-8 were used as experimental samples, and 30% was added to pure mineral ester and stirred evenly to make an ointment, which was used as the experimental group. The pure mineral ester ointment without addition was used as the control group, and they were marked as Groups 1-11 in sequence. 0.2 g of the corresponding sample was applied to the right ear of each group of mice. After 30 minutes, about 0.04 ml of xylene was applied to the front and back of the right auricle of each mouse for sensitization, and the left auricle was used as the normal control. After 30 minutes of sensitization, each group was smeared with the corresponding sample once again. After 1 hour, a 6 mm punch was used to punch round ear pieces in the same part of both ears, and the pieces were weighed with a precision balance. The weight difference (mg) of the two ear pieces was used as the degree of swelling, and the differences between the groups were compared.

[0126] Ointments prepared with 30% addition of the antioxidant and anti-inflammatory composition were prepared using Examples 1 and 3 and Comparative Examples 1-8. The swelling of the ears of mice smeared with the ointments was lower than that of the control group, as shown in the following table:

[0127] Addition concentration Swelling degree (x±s, mg) P-value Example 3 30 1.98 <0.01 Comparative Example 1 30 6.37 <0.01 Comparative Example 2 30 4.26 <0.01 Comparative Example 3 30 2.89 <0.01 Comparative Example 4 30 3.43 <0.01 Example 1 30 1.86 <0.01 Comparative Example 5 30 6.54 <0.01 Comparative Example 6 30 4.38 <0.01 Comparative Example 7 30 2.53 <0.01 Comparative Example 8 30 3.84 <0.01

[0128] From the above table, it can be seen that the composition of the present invention has a significant inhibitory effect on allergic inflammation caused by xylene, among which Example 1 has the highest inhibition rate on allergic inflammation caused by xylene, which also shows that the composition has a significant anti-inflammatory effect.

[0129] The parts not described in detail in this invention are prior art.

[0130] The embodiments selected herein for the purpose of disclosing the invention are presently considered suitable, but it should be understood that the invention is intended to include all variations and modifications of the embodiments that fall within the scope of the concept and invention.

Claims

1. An application of a composition of isoliquiritigenin (glycoside) and licochalcone and a group thereof in personal care products, characterized by: The composition is added to a facial mask, essence, gel, skin care ointment, cream, or sunscreen personal care product at a concentration of 0.005% to 10% (w / w). The components of the composition include isoliquiritigenin or its glycoside compound isoliquiritin, licorice chalcone A, and any one or any combination of two or more of licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G in its family. The isoliquiritigenin or its glycoside compound isoliquiritin accounts for 1 to 99% of the total weight of the composition by weight, and the licorice chalcone A, and its family group licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E, or licorice chalcone G account for 1 to 99% of the total weight of the composition by weight.

2. The use of the composition of isoliquiritigenin (glycoside) and licochalcone and their groups in personal care products according to claim 1, characterized in that: The weight ratio of the isoliquiritigenin or its glycoside compound isoliquiritin to licorice chalcone A and licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E or licorice chalcone G in its group is 1:99 to 99:

1.

3. The use of the composition of isoliquiritigenin (glycoside) and licochalcone and their groups in personal care products according to claim 1, characterized in that: The raw material purity of the isoliquiritigenin or its glycoside compound isoliquiritigenin is 5-99.99%.

4. The use of the composition of isoliquiritigenin (glycoside) and licochalcone and their groups in personal care products according to claim 1, characterized in that: The raw material purity of the licorice chalcone A and licorice chalcone B, licorice chalcone C, licorice chalcone D, licorice chalcone E or licorice chalcone G in the group thereof is 5-99.99%.

Images