The invention relates to effective emulsified paste for treating skin wound inflammation and a manufacturing method thereof. The effective emulsified paste for treating skin wound inflammation mainly comprises the following components in part by weight: 500 parts of Vaseline, 5 parts of camellia oil, 30 parts of powdered calamine, 0.3 part of vitamin A, 0.5 part of amoxicillin, and 2.4 parts of penicillin sodium in 4 million units. The effective emulsified paste is suitable for treating skin wounds of human body, skin diseases, water and fire burns, wound infection, herpes, balanitis, external candial infection, tinea cruris, pruritus vulvae, vaginal canker, anabrosis, nameless sores or boils, perianal abscess, ulcer, crystalli, impetigo, eczema, rhinitis, beriberi, dermatitis, itch, freckle removing and acne removing, has the characteristics of low production cost and obvious action effect, can effectively diminish swelling, relieve pain, eliminate necrotic tissues, promote granulation, promote growth of muscle cells of human body, accelerate the growth of skin cells, eliminate toxin, beautify skin, clear heat, promote diuresis, sterilize and relieve itching.