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Powder injection of sarcandra and its making method

A technology of sarcophagus and powder injection, which is applied in the field of sarcophagus powder injection and its preparation, can solve problems such as turbidity, precipitation, and affecting the therapeutic effect of drugs, and achieve the effect of drug safety and stable quality of preparations

Inactive Publication Date: 2005-10-12
山东特瑞林医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the formulations of sarcocarcinoides on the domestic market include solid preparations and injections. Its anti-inflammatory, heat-clearing, detoxification, relaxing tendons, activating blood circulation and anti-tumor effects are more and more recognized by patients. However, turbidity and precipitation often appear in traditional Chinese medicine injections. and other phenomena, which affect the quality of the product, thereby affecting the therapeutic effect of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 1000g of sargassum, decoct twice with water, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.33 (70°C), add ethanol for precipitation twice, and make the alcohol content for the first time 70%, the second alcohol content is 80%, refrigerated for 48 hours each time, filtered, the filtrate recovered ethanol and concentrated to 10g of crude drug per 1ml, added an appropriate amount of freshly prepared egg protein solution, stirred, precipitated, and refrigerated for 48 hours, filter, and boil the filtrate to coagulate the excess egg protein, filter, add ethanol to the filtrate to make the ethanol content 75%, place the precipitate, filter, recycle the ethanol from the filtrate, and obtain the sarcocarp extract. Then put the sargassum extract, 100g of mannitol, and 10g of Tween 80 together in a container, add an appropriate amount of water for injection, stir to dissolve, add water for injection to dilute to 1000ml, ...

Embodiment 2

[0017] Take 5000g of sargassum, decoct twice with water, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.33 (70°C), add ethanol for precipitation twice, the first time the alcohol content is 70%, the second alcohol content is 80%, refrigerated for 48 hours each time, filtered, the filtrate recovered ethanol and concentrated to 50g of crude drug per 1ml, added an appropriate amount of freshly prepared egg protein solution, stirred, precipitated, and refrigerated for 48 hours, filter, and boil the filtrate to coagulate the excess egg protein, filter, add ethanol to the filtrate to make the ethanol content 75%, place the precipitate, filter, recover ethanol from the filtrate, add an appropriate amount of water for injection, refrigerate for 24 hours, filter After filtering, the filtrate was adjusted to pH 9.0 with sodium hydroxide solution, added activated carbon to make it a concentration of 0.05%, boiled for 30 minutes, and f...

Embodiment 3

[0019] Take 10000g of sargassum, decoct twice with water, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.33 (70°C), add ethanol for precipitation twice, the first time the alcohol content is 70%, the second alcohol content is 80%, refrigerated for 48 hours each time, filtered, the filtrate recovered ethanol and concentrated to 100g of crude drug per 1ml, added an appropriate amount of freshly prepared egg protein solution, stirred, precipitated, and refrigerated for 48 hours, filter, and boil the filtrate to coagulate the excess egg protein, filter, add ethanol to the filtrate to make the ethanol content 75%, place the precipitate, filter, recover ethanol from the filtrate, add an appropriate amount of water for injection, refrigerate for 24 hours, filter However, get sargassum extract. Then put the sargassum extract, 20g of lactose, and 8g of sodium metabisulfite together in a container, add an appropriate amount of water...

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PUM

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Abstract

A powder injection for treating pneumonia, appendicitis, cellular tissue inflammation, bacterial dysentery, tumors, etc is prepared from glabrous sarcandra herb through extracting, mixing it with cosolvent and excipient and freeze drying.

Description

(1) Technical field [0001] The invention relates to a sarcomere powder injection and a preparation method thereof, belonging to the technical field of medicine. (2) Background technology [0002] Sarcandrabra Thunb (also known as Sarcandrabrabra Thunb) is a commonly used traditional Chinese medicine, and it is the whole herb of Sarcandrabrabra Thunb. It is a perennial herb or subshrub, 50-120 cm high. The roots are large, the stems are clustered, and the nodes are obvious. "The Pharmacopoeia of the People's Republic of China" 2000 Edition (Part One) records its use as a legal medicinal material. The flavor of swollen joints is bitter, pungent, flat in nature, slightly toxic, and has the effects of anti-inflammatory, heat-clearing, detoxifying, relaxing tendons and activating blood circulation. Sarcorrhea has a wide range of clinical applications, especially for inflammatory diseases of the respiratory tract and digestive tract. It is also often used to promote fracture he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61P1/04A61P11/00A61P19/08A61P29/00A61P35/00
CPCY02A50/30
Inventor 肖广常张颖孙锦光王淑娟
Owner 山东特瑞林医药科技发展有限公司
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