Oldenlandia and powder injection and preparation thereof

A technology of Hedyotis diffusa and Hedyotis diffusa powder, applied in the field of medicine, can solve the problems of turbidity, precipitation, affecting product quality, etc., and achieve the effects of drug safety and stable preparation quality.

Inactive Publication Date: 2005-10-12
山东特瑞林医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form of Hedyotis diffusa is currently on the market in China. However, turbidity and precipitation often occur in traditional Chinese medicine injections, which affect the quality of the product and thus affect the therapeutic efficacy of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 1000g of Hedyotis diffusa, crush it into coarse powder, use 80% ethanol as solvent, soak for 24 hours, slowly percolate, concentrate the filtrate to about 250ml, adjust the pH value to 12 with lime milk, refrigerate for 12 hours, filter , the filtrate was adjusted to pH 3 with 50% sulfuric acid solution, left to stand for 12 hours, filtered, the filtrate was adjusted to neutrality with 40% sodium hydroxide solution, 2000ml of ethanol was added, refrigerated for 24 hours, filtered, and the filtrate was concentrated under reduced pressure to 250ml, add water to 500ml, add an appropriate amount of activated carbon, stir well, filter, adjust the pH value of the filtrate to 6.5-7.0 with 40% sodium hydroxide solution, add 10g polysorbate 80, 1g sodium bisulfite, and 60g mannitol to fully Stir well, filter, add water for injection to 1000ml, add charcoal for needles, stir at room temperature, filter and decarbonize, fine filter, the filtrate is divided into 2ml sterilized ...

Embodiment 2

[0015] Take 500g of Hedyotis diffusa, crush it into coarse powder, use 80% ethanol as solvent, soak for 24 hours, slowly percolate, concentrate the filtrate to about 125ml, adjust the pH value to 12 with milk of lime, refrigerate for 12 hours, filter , the filtrate was adjusted to pH 3 with 50% sulfuric acid solution, left to stand for 12 hours, filtered, the filtrate was adjusted to neutrality with 40% sodium hydroxide solution, 1000ml of ethanol was added, refrigerated for 24 hours, filtered, and the filtrate was concentrated under reduced pressure to 125ml, add water to 500ml, add an appropriate amount of activated carbon, stir well, filter, adjust the pH of the filtrate to 6.5-7.0 with 40% sodium hydroxide solution, add 1g sodium metabisulfite, 60g sorbitol, stir well, filter , add water for injection to 1000ml, add charcoal for needles, stir at room temperature, filter to decarbonize, fine filter, and the filtrate is spray-dried to obtain Hedyotis diffusa powder injection....

Embodiment 3

[0017] Take 2000g of Hedyotis diffusa, crush it into coarse powder, use 80% ethanol as solvent, soak for 24 hours, slowly percolate, concentrate the filtrate to about 500ml, adjust the pH value to 12 with lime milk, refrigerate for 12 hours, filter , the filtrate was adjusted to pH 3 with 50% sulfuric acid solution, left to stand for 12 hours, filtered, the filtrate was adjusted to neutrality with 40% sodium hydroxide solution, added 4000ml of ethanol, refrigerated for 24 hours, filtered, and the filtrate was concentrated under reduced pressure to 500ml, add water to 2000ml, add an appropriate amount of activated carbon, stir well, filter, adjust the pH value of the filtrate to 6.5-7.0 with 40% sodium hydroxide solution, add 10g sodium sulfite, 10g glycine, stir well, filter, add water for injection to 5000ml, add charcoal for needles, stir at room temperature, decarbonize by filtration, fine filter, the filtrate is divided into 5ml sterilized vials, freeze-dried, stoppered, an...

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PUM

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Abstract

A powder injection for treating respiratory tract infection, tonsillitis, pneumonia, cholecystitis, appendicitis, cancers, etc is prepared from oldenlandia through extracting, refining, mixing it with cosolvent and excipient, and freeze drying.

Description

(1) Technical field [0001] The invention relates to a hedyotis diffusa powder injection and a preparation method thereof, belonging to the technical field of medicine. (2) Background technology [0002] Hedyotis diffusa is the whole herb of Rubiaceae Hedyotis diffusa. It mostly grows in wet fields, ditches, roadsides and grasslands, and is distributed in most parts of the country. Also known as Hedyotis. Its leaves are slender and long like a snake's tongue, and its flowers are pure white, so it is called "Hedyotis diffusa". Hedyotis diffusa is cold in nature, sweet and bitter in taste, and returns to the heart, lung, liver, and large intestine meridian. Modern pharmacological studies have confirmed that Hedyotis diffusa has anti-bacterial, anti-inflammatory, anti-tumor, anti-viral, and immune-enhancing effects. Hedyotis diffusa is currently marketed in the domestic market as an injection. However, turbidity and precipitation often occur in traditional Chinese medicine in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61P31/04A61P31/12A61P35/00
Inventor 肖广常张颖孙锦光王淑娟
Owner 山东特瑞林医药科技发展有限公司
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