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Local anti-inflammatory external medicinal composition using glycerol DMSO mixed solvent

A technology of mixing solvents and drugs for external use, applied in the field of medicine, can solve problems such as easy formation of flocs or precipitation, strong irritation of tinctures, and easy turbidity of aqueous solutions, so as to facilitate oxygen supply, avoid ulcers, and overcome easy cloudy effect

Inactive Publication Date: 2010-11-03
宫家君 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned traditional dosage form has the following disadvantages: the aqueous solution is easily turbid, easily forms flocs or precipitates, and is easy to mildew; the tincture has strong irritation, is volatile or precipitates; Its hydration can lead to pale and swollen skin, hindering wound healing

Method used

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  • Local anti-inflammatory external medicinal composition using glycerol DMSO mixed solvent
  • Local anti-inflammatory external medicinal composition using glycerol DMSO mixed solvent
  • Local anti-inflammatory external medicinal composition using glycerol DMSO mixed solvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Dimethyl sulfoxide glycerol solution (DMSO use concentration 50%)

[0046] Preparation method: Measure 500ml of glycerin and 500ml of DMSO, mix the two substances and stir evenly to obtain 1000ml of dimethyl sulfoxide glycerol solution.

[0047] DMSO is the first transdermal absorption enhancer widely used after the 1960s. It has a variety of pharmacological effects, can improve rat foot edema caused by carrageenan, and inhibit arthritis accompanied by fungal infection. Arthritis caused by 6-sulfanilamidazolez (new dosage form for transdermal administration / Zheng Junmin 2006: 42, 84), clinically used to treat some refractory diseases such as interstitial cystitis, scleroderma, persistent herpes zoster, Severe rheumatoid arthritis, and herpes simplex, acute eczema, especially eczema with obvious redness and swelling or a lot of exudate (Guidelines for Drug Treatment of Dermatological and Venereal Diseases / Hu Xiaojun et al. 2007: 138). At present, the direct treatment ...

Embodiment 2

[0049] Alum Dimethyl Sulfoxide Glycerin

[0050] Prescription: 50 grams of alum (the use concentration of alum is 5 grams / 100ml to make 1000ml of alum dimethyl sulfoxide glycerin).

[0051] Preparation:

[0052] The first step: prepare alum glycerin solution,

[0053] 1. Calculation: the concentration of alum is 5g / 100ml, the volume ratio of glycerin and DMSO is 4:1, then the concentration of alum preparation is 6.25g / 100ml;

[0054] 2. Weigh 62.5 grams of alum, and measure 1000ml of glycerin; dissolve the alum in the glycerin to obtain a 6.25g / 100ml preparation solution for later use;

[0055] The second step: preparation: measure 800ml of 6.25g / 100ml alum glycerol solution, add DMSO200ml, stir evenly, and make 1000ml of alum dimethyl sulfoxide glycerin.

[0056] Alum has special properties. Its chemical composition is hydrous aluminum potassium sulfate, which can condense particles to purify water. For medicinal purposes, it is rarely compatible with other traditional Chi...

Embodiment 3

[0061] The national standard Zhimi Lingsuppository ["Ministerial Standards" No. 11 Volume 118] is transformed into the 8th class new drug Zhi Mi Ling Oil (change the dried alum into the original shape alum to use).

[0062] Prescription: Phellodendron 10 grams, Sophora flavescens 10 grams, catechu 2 grams, borneol 1 gram, alum 50 g (1000 ml of Zhimi Ling oil).

[0063] Preparation:

[0064] The first step: prepare alum glycerin solution, same as embodiment 2;

[0065] The second step: extracting the ingredients of traditional Chinese medicine

[0066] 1. Wash 10 grams of Phellodendron Phellodendri, 10 grams of Sophora Sophorae, and 2 grams of catechu, put them in small pieces, put them in a porcelain container, add DMSO to submerge the medicinal materials, do the first extraction, soak for 8 hours, and filter out Get the extract 1, set aside;

[0067] 2. Then add DMSO in the same way for the second extraction to obtain the extract 2 and set aside;

[0068] 3. Then use the ...

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Abstract

The invention provides a local anti-inflammatory external medicinal composition using a glycerol DMSO mixed solvent, which comprises alum, a medicament with anti-inflammatory effective dose, and a mixed solvent which is used for dissolving the alum and the medicament and consists of dimethyl sulfoxide and glycerol in a volume ratio of 1:0.5-5. The external medicinal composition is a new dimethyl sulfoxide and glycerol external anti-inflammatory medicament, is used for treating various refractory and inflammatory mucocutaneous diseases, has the local anti-inflammatory effect by inhibiting inflammatory, and promotes injuries such as local blister, erosion, effusion, herpes and chronic ulcers to quickly heal.

Description

technical field [0001] The invention relates to the technical fields of medicine and population health, in particular to a local anti-inflammatory external pharmaceutical composition using a glycerin-DMSO mixed solvent. Background technique [0002] Inflammation is a defensive protective response for the body to fight against diseases, which is beneficial to the recovery of diseases. However, inflammation has a dual nature, that is, in the process of self-protection response, it often causes damage to its own tissues and aggravates the disease. The damage caused by the local reaction of inflammation is as follows: Blisters, ulcers, hyperplasia, etc., currently lack ideal therapeutic drugs. Inflammation can be caused by various reasons such as pathogenic microorganisms, physical and chemical factors, allergies, and immune reactions. Hyperplasia of three lesions. The development process is: in the early stage, exudation and infiltration are caused by vasodilation, and exudat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K47/20A61K47/10A61K36/756A61K36/195A61K36/70A61K36/315A61K36/538A61P29/00A61P31/02A61K31/10A61K31/045A61K31/155
Inventor 郭云霞宫家君宫远声陈建群宫瑜陈以旺
Owner 宫家君
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