Preparation method of ornidazole gastric floating tablets and use thereof

Abstract

The invention discloses a preparation method and applications of gastric floating tablets containing ornidazole, belonging to a novel technical field of medicament and relating to a novel medicament form of ornidazole. 1. The gastric floating tablets are used to treat a plurality of diseases caused by bacteroides fragilis, bacteroides distasonis, bacteroides oval window, etc.; (2) oral cavity infections: pericoronitis, periapical periodontitis, pericoronitis, acute ulcerouse gingivitis etc.; (3) gynae infections: endometritis, myometritis, oviduct or ovarian abscess, pelvic cavity soft tissue infection, haemophilis vaginitis etc.; (4) surgical infections: wound infection, abscess of epidermis, bedsore ulcerouse infection, cellulites, gas gangrene etc.; (5) brain infections: meningitis, brain abscess; (6) septicaemia and severe general infections etc. 2. The gastric floating tablets are used to prevent infections before an operation and treat anaerobic infections after an operation. 3. The gastric floating tablets are used to treat urogenital canal trichomonas and giardia lamblia infections, such as trichomoniasis etc. 4. The gastric floating tablets are used to treat alimentary system amebiasis, such as amebic dysentery, amoebic liver abscess etc. The new medicament form is characterized in that the surface thereof is hydrated into gel after contacting with gastric juice at body temperature so as to cause volume expansion because the gastric floating tablets contain a plurality of hydrophilic macromolecule materials. Weight of the tablets is less than floating force of the gastric juice, so the tablets float on the gastric juice so as to prolong time in a stomach.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of ornidazole, which is used for 1. treating bacteria caused by Bacteroides fragilis, Bacteroides distirii, Bacteroides ovale, Bacteroides polymorpha, Bacteroides vulgaris, Clostridium spp. Bacillus, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninus, Fusobacterium, CO 2 A variety of diseases caused by anaerobic infection such as Bacteroides phagocyticum and Bacteroides gingivalis, including: (1) Abdominal infection: peritonitis, abdominal abscess, liver abscess, peptic ulcer, necrotizing pneumonia, lung abscess, empyema, etc.; (2) Oral infection: periodontitis, periapical periodontitis, pericoronitis, acute ulcerative gingivitis, etc.; (3) Gynecological infection: endometritis, myositis, fallopian tube or ovarian abscess, pelvic soft tissue infection, Haemophilus vaginitis, etc.; (4) surgical infection: wound infectio...

AI Technical Summary

Problems solved by technology

Ornidazole is a new type of anti-anaerobic product. It is a 5-nitroimidazole derivative and an alternative product to tinidazole. We use it to treat bacterial vaginosis with good curative effect, short course of treatment, little gastrointestinal irritation, and easy to accept by patients Many data show that long-term oral tinidazole can cause peptic ulcer and reinfection, but there is no data report about ornidazole

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