Preparation method of ornidazole gastric floating tablets and use thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of ornidazole gastric and gastric floating tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, and resistance to vector-borne diseases, etc., can solve problems such as short course of treatment, and achieve simple methods, high quality and stability Good results
Inactive Publication Date: 2009-06-17
BEIJING HOPE HUGE PHARM SCI
View PDF0 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Ornidazole is a new type of anti-anaerobic product. It is a 5-nitroimidazole derivative and an alternative product to tinidazole. We use it to treat bacterial vaginosis with good curative effect, short course of treatment, little gastrointestinal irritation, and easy to accept by patients Many data show that long-term oral tinidazole can cause peptic ulcer and reinfection, but there is no data report about ornidazole
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0038] Embodiment 1: specification 1000 pieces
[0039] prescription:
[0040] Ornidazole 250 parts
[0041] Hydroxypropyl cellulose 100 parts
[0042] Hydroxyethylcellulose 120 parts
[0043] Acrylic resin 500 parts
[0044] Sodium bicarbonate 100 parts
[0045] Micronized silica gel 1 part
[0046] Sodium dodecyl sulfate 0.5 parts
[0047] Preparation method:
[0048] Mix the prescription amount of ornidazole, hydroxypropyl cellulose, hydroxyethyl cellulose, acrylic resin, and sodium bicarbonate evenly, and then mix them with an 80-mesh sieve, add micropowder silica gel and sodium dodecylsulfonate, Mix the raw and auxiliary materials evenly, directly compress the tablet, inspect the finished product, and pack.
Embodiment 2
[0049] Embodiment 2: specification 10000 pieces
[0050] prescription:
[0051] Ornidazole 2500g
[0052] Hydroxypropyl Cellulose 1000g
[0053] Hydroxyethyl Cellulose 1200g
[0054] Acrylic resin 5000g
[0055] Sodium bicarbonate 1000g
[0056] Micronized silica gel 10g
[0057] Sodium dodecyl sulfonate 5g
[0058] Preparation method:
[0059] Mix the prescription amount of ornidazole, hydroxypropyl cellulose, hydroxyethyl cellulose, acrylic resin, and sodium bicarbonate evenly, and then mix them with an 80-mesh sieve, add micropowder silica gel and sodium dodecylsulfonate, Mix the raw and auxiliary materials evenly, directly compress the tablet, inspect the finished product, and pack.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a preparation method and applications of gastric floating tablets containing ornidazole, belonging to a novel technical field of medicament and relating to a novel medicament form of ornidazole. 1. The gastric floating tablets are used to treat a plurality of diseases caused by bacteroides fragilis, bacteroides distasonis, bacteroides oval window, etc.; (2) oral cavity infections: pericoronitis, periapical periodontitis, pericoronitis, acute ulcerouse gingivitis etc.; (3) gynae infections: endometritis, myometritis, oviduct or ovarian abscess, pelvic cavity soft tissue infection, haemophilis vaginitis etc.; (4) surgical infections: wound infection, abscess of epidermis, bedsore ulcerouse infection, cellulites, gas gangrene etc.; (5) brain infections: meningitis, brain abscess; (6) septicaemia and severe general infections etc. 2. The gastric floating tablets are used to prevent infections before an operation and treat anaerobic infections after an operation. 3. The gastric floating tablets are used to treat urogenital canal trichomonas and giardia lamblia infections, such as trichomoniasis etc. 4. The gastric floating tablets are used to treat alimentary system amebiasis, such as amebic dysentery, amoebic liver abscess etc. The new medicament form is characterized in that the surface thereof is hydrated into gel after contacting with gastric juice at body temperature so as to cause volume expansion because the gastric floating tablets contain a plurality of hydrophilic macromolecule materials. Weight of the tablets is less than floating force of the gastric juice, so the tablets float on the gastric juice so as to prolong time in a stomach.
Description
technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of ornidazole, which is used for 1. treating bacteria caused by Bacteroides fragilis, Bacteroides distirii, Bacteroides ovale, Bacteroides polymorpha, Bacteroides vulgaris, Clostridium spp. Bacillus, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninus, Fusobacterium, CO 2 A variety of diseases caused by anaerobic infection such as Bacteroides phagocyticum and Bacteroides gingivalis, including: (1) Abdominal infection: peritonitis, abdominal abscess, liver abscess, peptic ulcer, necrotizing pneumonia, lung abscess, empyema, etc.; (2) Oral infection: periodontitis, periapical periodontitis, pericoronitis, acute ulcerative gingivitis, etc.; (3) Gynecological infection: endometritis, myositis, fallopian tube or ovarian abscess, pelvic soft tissue infection, Haemophilus vaginitis, etc.; (4) surgical infection: wound infectio...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more