53 results about "Ectopic sebaceous glands" patented technology

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

The invention belongs to the technical field of natural products, and provides application of fucoxanthin in preparation of oral anti-alopecia drugs. Animal experiments find that long-term high-fat diet can lead to large-piece shedding of hair accompanied by skin inflammation, and fucoxanthin has a treatment effect on high-fat diet induced mouse back hair shedding and skin inflammation, can obviously relieve high-fat diet induced subcutaneous cholesterol crystal accumulation and sebaceous gland cell hypertrophy, and has the effects of preventing and treating the high-fat diet induced mouse back hair shedding and skin inflammation and preventing and treating the high-fat diet induced mouse back hair shedding and the high-fat diet induced sebaceous gland cell hypertrophy. And skin epidermal hyperplasia and cuticle thickening induced by high fat diet can be improved. Besides, cell experiments also find that fucoxanthin intervention can reduce oleic acid infiltration of the hair follicle stem cells and reduce oleic acid induced death and apoptosis of the hair follicle stem cells, and prove that fucoxanthin has a protection effect on the hair follicle stem cells, has low toxic and side effects on cells and animals as a natural algae extract, and has a good application prospect. Good clinical application prospects are realized.

The invention discloses a composition containing saccharomycetes / rice fermentation product filtrate, which has the effects of controlling oil and repairing hair. The composition comprises saccharomycetes / rice fermentation product filtrate, a rice husk extract, a tuber melanosporum extract and a millet seed extract. The invention also provides an application of the composition in preparation of oil-controlling, repairing and washing products, shampoo containing the composition and a preparation method of the shampoo. Experimental results show that the composition can significantly inhibit grease secretion of human sebaceous gland cells, repair hair and improve smoothness and glossiness of hair. The composition disclosed by the invention has the advantages of strong synergistic effect of all components, safety, no irritation, simple preparation process and suitability for industrial production.

The invention belongs to the technical field of compositions capable of generating foam, and particularly relates to a composition containing a thiohydantoin compound. The composition contains a compound of formula (I) or a pharmaceutically acceptable salt thereof. The foam composition is convenient to use and high in stability, and can be used for treating, preventing or relieving androgen-mediated disorders, diseases or symptoms, such as acne, hirsutism, sebaceous gland enlargement or androgenetic alopecia.

The present invention provides a novel promoter for lipid synthesis in sebaceous gland cells. By using the novel promoter for lipid synthesis in sebaceous gland cells, a skin barrier damage repairing agent and cosmetics with a skin barrier damage repairing function can be prepared, so that cosmetics for repairing skin barrier damage of at least one type selected from skin dryness, premature skin aging, skin aging, skin pruritus, and senile sebaceous deficiency eczema caused by hypofunction of sebaceous glands and / or reduced sebum secretion can be developed.

The present application belongs to the field of daily chemicals, and particularly relates to a skin care composition containing Physocarpus fruit extract, which comprises the following components calculated by weight percentage: Physocarpus fruit extract 0.01-6.0%; humectant 0.1-15.0%; oil 5.0-30.0%; emulsifier 1.0-10.0%; thickening agent 0.1-5.0%; preservative 0.5-2.0%; and the balance of pure water. The skin care composition of the present application not only can improve the symptom of excessive secretion of sebaceous glands, dredge the blocked pores, effectively reduce the generation of comedones and inflammatory acne, but also has excellent soothing and redness fading ability, can quickly calm the existing red and swollen acne skin, and reduce the stinging and uncomfortable feeling caused by acne. In addition, after using the composition of the present application, the secretion of sweat and oil can be reduced, so as to achieve the effect of reducing body odor.

A method of treating Hidradenitis Suppurativa (HS) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

To provide a method for evaluating the therapeutic and / or prophylactic action of a skin disease caused by the obstruction and / or inflammation of a pilosebaceous gland system.SOLUTION: A method for evaluating a therapeutic and / or prophylactic action of a substance or agent on a skin disease, the method comprising: bringing the substance or agent into contact with sebocytes or progenitor cells thereof; and evaluating the sebocytes or progenitor cells thereof, wherein the skin disease is a skin disease caused by obstruction and / or inflammation of the pilosebaceous unit.SELECTED DRAWING: None

A method of treating Sebaceous Hyperplasia (SH) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

This invention belongs to the field of skin care technology and discloses an oil-controlling composition, its uses, and skin care products. The oil-controlling composition, by weight, comprises 0.5-1 parts of zinc PCA, 4-9 parts of niacinamide, 0.5-2 parts of pink passionflower extract, and 0.3-0.7 parts of acetyl tetrapeptide-5. The oil-controlling composition of this invention not only inhibits 5α-reductase activity but also promotes autophagy in sebaceous gland cells, thereby enhancing the oil-controlling efficacy of the composition.

The invention discloses oil-controlling and dandruff-removing shampoo and a preparation method thereof. The shampoo comprises an anti-malassezia single-domain antibody with an amino acid sequence as shown in SEQ ID NO: 1 and an asparagus cochinchinensis root extract obtained through supercritical carbon dioxide extraction. The activity retention rate of the antibody is not lower than 80% after the antibody is stored in a shampoo matrix at 40 DEG C for 28 days. The total polyphenol content of the extract is not less than 5%. Chessboard microdilution determination shows that the antibody and the extract have a synergistic effect in the aspect of inhibiting malassezia, and the synergistic index is less than 0.9. Cell experiments show that the extract can down-regulate gene expression of 5 alpha-reductase in human sebaceous gland cells. A human body test result shows that after the shampoo is used for 4 weeks, the dandruff score of a subject is reduced by 82.5%, the scalp grease content is reduced by 64.1%, the malassezia quantity is reduced by 47.8%, and the effect is superior to that of a single component and a commercially available chemical dandruff removing product. The shampoo has excellent stability, synergistic effect and clinical application effect, and has a relatively high industrial application prospect.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

Incorporation of lipids into a growing hair fibre is provided by a composition comprising at least one of: 1) 0.05 to 8 wt % of a lipid precursor selected from the group consisting of a fatty acid having a chain of 6 to 24 carbon atoms, an ester or an acylglycerol thereof and mixtures thereof; 2) 0.05 to 8.0% of a "gene activator material" that modulates the biosynthesis of lipids in the hair follicle or sebaceous gland, selected from a) at least one activator of a peroxisome proliferator-activated receptor (PPAR activator), b) at least one activator of a liver X receptor (LXR), and c) at least one activator of a retinoid X receptor (RXR); and 3) a fatty alcohol having a chain of 6 to 24 carbon atoms, preferably 8 to 20 carbon atoms, most preferably 10 to 18 carbon atoms; and mixtures thereof; and a cosmetically acceptable carrier.

The present disclosure relates, in part, to a method of treating acne, excessive sweating, unwanted hair, and / or unwanted blood vessels. The method can include providing a needle array comprising a plurality of needles; inserting the plurality of needles into a dermis of a treatment area; detecting a location of an enlarged sebaceous gland; and exciting one or more of the plurality of needles to treat the sebaceous gland, one or more sweat glands, a vascular lesion, an unwanted hair follicle, and / or an unwanted blood vessel.

To provide a technique relating to total secretion regulation of sebaceous gland cells.SOLUTION: The present invention provides a total secretion regulator comprising a compound selected from the group consisting of oligosaccharides and macrolide compounds as an active ingredient.SELECTED DRAWING: None

The invention provides application of an autoinducible factor 2 in preparation of a product for preventing or treating acne. Experiments show that the expression quantity of the autoinducible factor 2 in diseased skin tissues and sebum secretions of acne patients is obviously higher than that of healthy people; in an acne cell model, the autoinducible factor 2 can significantly up-regulate expression of inflammatory factors such as IL-1, IL-6, TNF-alpha and the like by activating an NF-kappa B pathway, and meanwhile, the secretion amount of sebum in sebaceous gland cells is promoted. Therefore, the autoinducible factor 2 serves as a new target for acne treatment, related inhibition products of the autoinducible factor 2 have definite prevention and treatment effects on acne, the autoinducible factor 2 has huge potential of being developed into corresponding drugs, medical instruments or skin care products, and meanwhile a new technical direction is provided for solving the problems of drug resistance, side effects and the like of existing acne treatment.

The invention discloses a new application of isopentadecanoic acid, and discloses an application of isopentadecanoic acid in preparation of skin care cosmetics, isopentadecanoic acid has the effects of up-regulating expression of hBD-2 and silk protein in human immortalized keratinocytes, reducing expression synthesis of ROS and TRPV1 in the human immortalized keratinocytes, inhibiting release of NO by mouse macrophages, and inhibiting expression of the human immortalized keratinocytes. And the secretion of sebaceous gland cell grease is reduced.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a rose mud mask for cosmetics, rose mud and application. The rose paste is prepared from rose paste and auxiliary materials, the rose mud is prepared from rose residues and a composite strain, the composite strain comprises lactobacillus and saccharomycetes in a mass ratio of (50-100): (0.1-1), the saccharomycetes are Bernoulli yeast, and the lactobacillus is lactobacillus plantarum. The rose mud prepared by the method has the remarkable effects of inhibiting sebaceous gland cell grease secretion, increasing the water content of skin, scavenging free radicals and the like, and the rose mud mask prepared by the method has the better effects of regulating oil-water balance and grease balance of skin, resisting wrinkles, improving skin elasticity and the like.

The present application belongs to the technical field of microbial fermentation, and particularly relates to a kind of cosmetic rose mud mask, rose flower mud and application. Its raw material includes rose flower mud and auxiliary material;The preparation raw material of the rose flower mud includes: rose flower residue and composite bacterial species, the composite bacterial species includes mass ratio 50-100:0.1-1 of lactobacillus and yeast, the yeast is bayaun yeast, and the lactobacillus is lactobacillus plantarum. The rose flower mud prepared by the present application has the effects of significantly inhibiting sebaceous gland cell oil secretion, improving skin water content, scavenging free radicals and the like, and the rose mud mask prepared by the present application has the effects of better regulating skin oil balance, oil balance, anti-wrinkle, improving skin elasticity and the like.

The application belongs to the technical field of cosmetics, and discloses an oil control composition, application and cosmetics thereof. The oil control composition is obtained by water extraction of a plant combination of bitter almond seeds, reed, radix ophiopogonis and kaempferia galanga roots. The weight ratio of the bitter almond seeds, reed, radix ophiopogonis and kaempferia galanga roots in the plant combination is 3-7:4-8:3-7:1-6. When the four plant extracts are used together, a synergistic effect can be achieved, the skin is acted on through multiple pathways, the synthesis and secretion of lipids in sebaceous gland cells are reduced, and the skin oil is decomposed. The oil control composition has a high 5alpha-reductase inhibition rate, and has an excellent oil control effect.

The invention relates to application of Antarctic red in a skin conditioning agent for synergistically controlling oil and resisting wrinkles, and belongs to the technical field of biology, the Antarctic red has no toxicity to cells when the concentration is not higher than 250 g / mL, gene expression of I-type 5 alpha-reductase in sebaceous gland cells is inhibited in a targeted mode, and excessive synthesis of grease is reduced from the source; the gene expression level of I type and III type collagen in dermal fibroblasts is synchronously improved, so that the internal support structure of the skin is reconstructed, and the anti-wrinkle effect is realized. According to the Antarctic red disclosed by the invention, through the synergistic effect of'descending and ascending ', the Antarctic red is proved to be capable of simultaneously and accurately intervening an'oil-wrinkle' associated pathway, and the limitation of a single functional component is broken through.

A method of treating Sebaceous Hyperplasia (SH) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

The invention discloses a new application of schizonepeta fordii vesicles, which is realized through in-vitro cells, and proves that the schizonepeta fordii vesicles can obviously reduce the expression of TNF-alpha and NF-kappa B inflammatory factors of macrophages, reduce the expression of TRPV1 of keratinocytes, increase the expression of LOR and FLG of the keratinocytes and reduce the expression of SREBP-1 and ACC of sebaceous gland cells. The schizonepeta tenuifolia vesicle has the advantages that the schizonepeta tenuifolia vesicle has obvious soothing, repairing, oil control and tightening effects and can be applied to a skin care product with at least one of soothing, repairing, oil control and tightening effects, and accordingly the schizonepeta tenuifolia vesicle can be applied to skin care products with at least one of soothing, repairing, oil control and tightening effects by the aid of the schizonepeta tenuifolia vesicle.

The invention discloses an azelaic acid yeast fermentation product and a preparation method thereof, and belongs to the technical field of microorganisms. According to the invention, the preparation of the azelaic acid supramolecular eutectic is realized by utilizing microbial fermentation. The prepared azelaic acid yeast fermentation product can repair skin cells damaged by ultraviolet radiation, improve the tolerance of the skin cells to the ultraviolet radiation, inhibit overexpression of sebum by sebaceous gland cells, inhibit growth of propionibacterium acnes and inhibit the activity of 5 alpha-reductase, has the effects of controlling oil, removing acnes and repairing skin, and can be used for repairing skin cells damaged by ultraviolet radiation. The composition is especially suitable for oil-controlling and acne-removing cosmetics. The azelaic acid yeast fermentation product is prepared through microbial fermentation, and the method has the advantages of being environmentally friendly, mild in condition and the like.

The invention belongs to the technical field of cosmetics, and discloses an oil control composition and application thereof and cosmetics, the oil control composition is obtained by water extraction of a plant combination of bitter almond seeds, reeds, radix ophiopogonis roots and rhizoma kaempferiae roots, and the weight ratio of the bitter almond seeds to the reeds to the radix ophiopogonis roots to the rhizoma kaempferiae roots in the plant combination is (3-7): (4-8): (3-7): (1-6); when the four plant extracts are used together, the four plant extracts can play a synergistic role, act on the skin through multiple pathways, reduce synthesis and secretion of lipid in sebaceous gland cells and decompose skin grease, and have a higher 5alpha-reductase inhibition rate and an excellent oil control effect.

The invention discloses an oil control composition for regulating sebaceous glands and a preparation method and application thereof, and belongs to the technical field of cosmetics, the oil control composition for regulating sebaceous glands comprises the following components in parts by mass: 0.5-10 parts of 10-hydroxydecanoic acid, 5-25 parts of sarcosine and 5-50 parts of an oil control agent, the oil control agent comprises a Thermus thermophilus fermentation product, the mass percentage content of the Thermus thermophilus fermentation product in the oil control agent is not less than 80%; the 10-hydroxydecanoic acid, the sarcosine and the oil control agent are combined according to the specific mass parts to obtain the composition with an excellent oil control effect, and the composition can effectively inhibit 5 alpha-reductase in sebaceous gland cells, reduce conversion of testosterone to dihydrotestosterone (DHT), inhibit sebaceous gland secretion and reduce grease accumulation on the skin surface, so that the sebaceous gland skin-care effect is improved, and the skin-care effect is improved. Pore blockage is reduced, the number of active sebaceous gland bodies is reduced, the secretion activity of the active sebaceous gland bodies is reduced, and skin grease is effectively reduced.

The invention belongs to the technical field of skin care, and discloses an oil control composition, application and a skincare product, and the oil control composition comprises the following components in parts by weight: 0.5-1 part of PCA zinc, 4-9 parts of nicotinamide, 0.5-2 parts of pink passion flower extract and 0.3-0.7 part of acetyl tetrapeptide-5. The oil control composition not only can inhibit the activity of 5 alpha-reductase, but also has the effect of promoting sebaceous gland cell autophagy, so that the oil control effect of the composition is improved.

The present application relates to the field of daily chemicals, and discloses a skin oil control composition which has a synergistic inhibitory effect on 5alpha-reductase in skin tissue, thereby achieving inhibition of sebaceous glands to secrete sebum, and is composed of saw palm extract, radix astragali extract and coltsfoot leaf extract components; the application of the oil control composition for hair includes the following main components: the skin oil control composition, auxiliary oil control additives, base cleaning agent, amino acid surfactant, auxiliary surfactant, thickening agent, scalp conditioner and pearl agent. The effective components of the product can form a synergistic effect, effectively inhibit 5alpha-reductase, and further inhibit the secretion of sebum in the sebaceous glands in the skin tissue, so as to achieve the effect of long-acting maintenance of scalp health and clean and beautiful hair.