36 results about "Ectopic sebaceous glands" patented technology

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The invention discloses a composition containing saccharomycetes / rice fermentation product filtrate, which has the effects of controlling oil and repairing hair. The composition comprises saccharomycetes / rice fermentation product filtrate, a rice husk extract, a tuber melanosporum extract and a millet seed extract. The invention also provides an application of the composition in preparation of oil-controlling, repairing and washing products, shampoo containing the composition and a preparation method of the shampoo. Experimental results show that the composition can significantly inhibit grease secretion of human sebaceous gland cells, repair hair and improve smoothness and glossiness of hair. The composition disclosed by the invention has the advantages of strong synergistic effect of all components, safety, no irritation, simple preparation process and suitability for industrial production.

The invention belongs to the technical field of compositions capable of generating foam, and particularly relates to a composition containing a thiohydantoin compound. The composition contains a compound of formula (I) or a pharmaceutically acceptable salt thereof. The foam composition is convenient to use and high in stability, and can be used for treating, preventing or relieving androgen-mediated disorders, diseases or symptoms, such as acne, hirsutism, sebaceous gland enlargement or androgenetic alopecia.

The present invention provides a novel promoter for lipid synthesis in sebaceous gland cells. By using the novel promoter for lipid synthesis in sebaceous gland cells, a skin barrier damage repairing agent and cosmetics with a skin barrier damage repairing function can be prepared, so that cosmetics for repairing skin barrier damage of at least one type selected from skin dryness, premature skin aging, skin aging, skin pruritus, and senile sebaceous deficiency eczema caused by hypofunction of sebaceous glands and / or reduced sebum secretion can be developed.

The present application belongs to the field of daily chemicals, and particularly relates to a skin care composition containing Physocarpus fruit extract, which comprises the following components calculated by weight percentage: Physocarpus fruit extract 0.01-6.0%; humectant 0.1-15.0%; oil 5.0-30.0%; emulsifier 1.0-10.0%; thickening agent 0.1-5.0%; preservative 0.5-2.0%; and the balance of pure water. The skin care composition of the present application not only can improve the symptom of excessive secretion of sebaceous glands, dredge the blocked pores, effectively reduce the generation of comedones and inflammatory acne, but also has excellent soothing and redness fading ability, can quickly calm the existing red and swollen acne skin, and reduce the stinging and uncomfortable feeling caused by acne. In addition, after using the composition of the present application, the secretion of sweat and oil can be reduced, so as to achieve the effect of reducing body odor.

A method of treating Hidradenitis Suppurativa (HS) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

To provide a method for evaluating the therapeutic and / or prophylactic action of a skin disease caused by the obstruction and / or inflammation of a pilosebaceous gland system.SOLUTION: A method for evaluating a therapeutic and / or prophylactic action of a substance or agent on a skin disease, the method comprising: bringing the substance or agent into contact with sebocytes or progenitor cells thereof; and evaluating the sebocytes or progenitor cells thereof, wherein the skin disease is a skin disease caused by obstruction and / or inflammation of the pilosebaceous unit.SELECTED DRAWING: None

A method of treating Sebaceous Hyperplasia (SH) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The invention discloses oil-controlling and dandruff-removing shampoo and a preparation method thereof. The shampoo comprises an anti-malassezia single-domain antibody with an amino acid sequence as shown in SEQ ID NO: 1 and an asparagus cochinchinensis root extract obtained through supercritical carbon dioxide extraction. The activity retention rate of the antibody is not lower than 80% after the antibody is stored in a shampoo matrix at 40 DEG C for 28 days. The total polyphenol content of the extract is not less than 5%. Chessboard microdilution determination shows that the antibody and the extract have a synergistic effect in the aspect of inhibiting malassezia, and the synergistic index is less than 0.9. Cell experiments show that the extract can down-regulate gene expression of 5 alpha-reductase in human sebaceous gland cells. A human body test result shows that after the shampoo is used for 4 weeks, the dandruff score of a subject is reduced by 82.5%, the scalp grease content is reduced by 64.1%, the malassezia quantity is reduced by 47.8%, and the effect is superior to that of a single component and a commercially available chemical dandruff removing product. The shampoo has excellent stability, synergistic effect and clinical application effect, and has a relatively high industrial application prospect.

The invention provides shampoo for controlling oil and relieving itching and a preparation method thereof, and relates to the technical field of shampoo. The shampoo is prepared from the following raw materials in parts by weight: 10 to 14 parts of camellia oil, 20 to 30 parts of plant extract, 7 to 10 parts of euglena parviflora root powder, 3 to 6 parts of vitamin E, 10 to 13 parts of butyrospermum parviflora butter, 6 to 8 parts of hydrolyzed silk protein, 7 to 9 parts of euglena parviflora polysaccharide, 4 to 7 parts of amino acid, 14 to 18 parts of surfactant, 2 to 4 parts of hydroxyethyl cellulose and 70 to 90 parts of water. The shampoo has good foaming and scalp dirt cleaning performance and can inhibit excessive secretion of sebaceous gland cells and reduce scalp grease generation, active ingredients can permeate into the inner layer of scalp to supplement moisture and nutrition, meanwhile, a protective layer can be formed on the surface layer of the scalp, the damaged scalp barrier of children is repaired, the scalp resistance is enhanced, and the hair is protected. Therefore, good oil control and itching relieving effects are achieved, and the effect is mild.

Incorporation of lipids into a growing hair fibre is provided by a composition comprising at least one of: 1) 0.05 to 8 wt % of a lipid precursor selected from the group consisting of a fatty acid having a chain of 6 to 24 carbon atoms, an ester or an acylglycerol thereof and mixtures thereof; 2) 0.05 to 8.0% of a "gene activator material" that modulates the biosynthesis of lipids in the hair follicle or sebaceous gland, selected from a) at least one activator of a peroxisome proliferator-activated receptor (PPAR activator), b) at least one activator of a liver X receptor (LXR), and c) at least one activator of a retinoid X receptor (RXR); and 3) a fatty alcohol having a chain of 6 to 24 carbon atoms, preferably 8 to 20 carbon atoms, most preferably 10 to 18 carbon atoms; and mixtures thereof; and a cosmetically acceptable carrier.

The present disclosure relates, in part, to a method of treating acne, excessive sweating, unwanted hair, and / or unwanted blood vessels. The method can include providing a needle array comprising a plurality of needles; inserting the plurality of needles into a dermis of a treatment area; detecting a location of an enlarged sebaceous gland; and exciting one or more of the plurality of needles to treat the sebaceous gland, one or more sweat glands, a vascular lesion, an unwanted hair follicle, and / or an unwanted blood vessel.

To provide a technique relating to total secretion regulation of sebaceous gland cells.SOLUTION: The present invention provides a total secretion regulator comprising a compound selected from the group consisting of oligosaccharides and macrolide compounds as an active ingredient.SELECTED DRAWING: None

The invention provides application of an autoinducible factor 2 in preparation of a product for preventing or treating acne. Experiments show that the expression quantity of the autoinducible factor 2 in diseased skin tissues and sebum secretions of acne patients is obviously higher than that of healthy people; in an acne cell model, the autoinducible factor 2 can significantly up-regulate expression of inflammatory factors such as IL-1, IL-6, TNF-alpha and the like by activating an NF-kappa B pathway, and meanwhile, the secretion amount of sebum in sebaceous gland cells is promoted. Therefore, the autoinducible factor 2 serves as a new target for acne treatment, related inhibition products of the autoinducible factor 2 have definite prevention and treatment effects on acne, the autoinducible factor 2 has huge potential of being developed into corresponding drugs, medical instruments or skin care products, and meanwhile a new technical direction is provided for solving the problems of drug resistance, side effects and the like of existing acne treatment.

The present application belongs to the technical field of microbial fermentation, and particularly relates to a kind of cosmetic rose mud mask, rose flower mud and application. Its raw material includes rose flower mud and auxiliary material;The preparation raw material of the rose flower mud includes: rose flower residue and composite bacterial species, the composite bacterial species includes mass ratio 50-100:0.1-1 of lactobacillus and yeast, the yeast is bayaun yeast, and the lactobacillus is lactobacillus plantarum. The rose flower mud prepared by the present application has the effects of significantly inhibiting sebaceous gland cell oil secretion, improving skin water content, scavenging free radicals and the like, and the rose mud mask prepared by the present application has the effects of better regulating skin oil balance, oil balance, anti-wrinkle, improving skin elasticity and the like.

The invention relates to application of Antarctic red in a skin conditioning agent for synergistically controlling oil and resisting wrinkles, and belongs to the technical field of biology, the Antarctic red has no toxicity to cells when the concentration is not higher than 250 g / mL, gene expression of I-type 5 alpha-reductase in sebaceous gland cells is inhibited in a targeted mode, and excessive synthesis of grease is reduced from the source; the gene expression level of I type and III type collagen in dermal fibroblasts is synchronously improved, so that the internal support structure of the skin is reconstructed, and the anti-wrinkle effect is realized. According to the Antarctic red disclosed by the invention, through the synergistic effect of'descending and ascending ', the Antarctic red is proved to be capable of simultaneously and accurately intervening an'oil-wrinkle' associated pathway, and the limitation of a single functional component is broken through.

A method of treating Sebaceous Hyperplasia (SH) using a 1726 nm laser pulse that selectively targets sebum produced by the sebaceous glands.

The invention discloses a new application of schizonepeta fordii vesicles, which is realized through in-vitro cells, and proves that the schizonepeta fordii vesicles can obviously reduce the expression of TNF-alpha and NF-kappa B inflammatory factors of macrophages, reduce the expression of TRPV1 of keratinocytes, increase the expression of LOR and FLG of the keratinocytes and reduce the expression of SREBP-1 and ACC of sebaceous gland cells. The schizonepeta tenuifolia vesicle has the advantages that the schizonepeta tenuifolia vesicle has obvious soothing, repairing, oil control and tightening effects and can be applied to a skin care product with at least one of soothing, repairing, oil control and tightening effects, and accordingly the schizonepeta tenuifolia vesicle can be applied to skin care products with at least one of soothing, repairing, oil control and tightening effects by the aid of the schizonepeta tenuifolia vesicle.

The present application relates to the field of daily chemicals, and discloses a skin oil control composition which has a synergistic inhibitory effect on 5alpha-reductase in skin tissue, thereby achieving inhibition of sebaceous glands to secrete sebum, and is composed of saw palm extract, radix astragali extract and coltsfoot leaf extract components; the application of the oil control composition for hair includes the following main components: the skin oil control composition, auxiliary oil control additives, base cleaning agent, amino acid surfactant, auxiliary surfactant, thickening agent, scalp conditioner and pearl agent. The effective components of the product can form a synergistic effect, effectively inhibit 5alpha-reductase, and further inhibit the secretion of sebum in the sebaceous glands in the skin tissue, so as to achieve the effect of long-acting maintenance of scalp health and clean and beautiful hair.

The embodiment of the present application provides a cosmetic composition with oil control, pore shrinking and moisturizing repair functions and application thereof. The cosmetic composition comprises, by weight percentage, 50-85% of Hamamelis virginiana water, 10-25% of butanediol, 1-5% of 1,2-pentanediol and 0.1-1% of decanediol, based on the total weight of the cosmetic composition. The cosmetic composition provided by the embodiment of the present application can not only achieve rapid oil control, but also achieve moisturizing, ensure skin water and oil balance through the effects of rapid oil control and moisturizing, avoid the occurrence of sebaceous gland compensatory secretion, form a virtuous cycle, and can quickly shrink pores and enhance skin barrier function.

The application discloses a ylang-ylang flower composite repair factor, a preparation method and application, relates to the field of daily necessities, and contains the following components in mass fractions: ylang-ylang flower extract 1-10 parts, hydrolyzed keratin 0.1-5 parts, gynostemma pentaphyllum extract 0.5-8 parts, urea 0.1-3 parts, trehalose 0.5-6 parts, zinc PCA 0.1-3 parts and schizochytrium fermentum filtrate 10-50 parts; wherein the ylang-ylang flower extract is extractum obtained by alcohol extraction and ethyl acetate extraction of ylang-ylang flowers, and the total terpene content is not less than 15% in terms of drimane D; the molecular weight of the hydrolyzed keratin is 500-3000 Da; the ylang-ylang flower composite repair factor, the preparation method and the application construct a ylang-ylang flower extract plus zinc PCA bidirectional oil control channel, and inhibit excessive secretion of sebum from both lipid synthesis in sebaceous gland cells and hormone signals.

The invention belongs to the technical field of biological materials, and particularly relates to a functional sebaceous gland-skin integrated model based on biological 3D printing and a construction method and application of the functional sebaceous gland-skin integrated model. The double-nozzle collaborative printing technology is adopted, a complete sebaceous gland-catheter-epidermis secretion path is successfully constructed, directional transportation of lipid secretion is achieved, and seamless communication between the catheter and the epidermis is achieved. Meanwhile, specific bio-ink is selected in the printing process, the mechanical stability of the model can be remarkably improved, and the collapse rate within 7 days after printing can be controlled to be 5% or below. The model precisely simulates natural anatomical characteristics in structure, the mechanical property is close to that of a natural catheter basement membrane, the problems that a secretion path is blocked, a catheter is prone to collapse and the like generally existing in a traditional model are effectively solved, and more reliable model support is provided for related research and application.

The invention discloses an in-vitro evaluation system for evaluating the sebum secretion effect of a sunscreen product, and belongs to the field of cosmetic detection. The system comprises a sebum secretion regulation and control evaluation module, a sample treatment module and an ultraviolet radiation module, the state of a sunscreen product in actual use is simulated through a specially-made transparent cover assembly, and differentiated treatment flows are designed for physical and chemical sunscreen samples and biological sunscreen and oil control samples respectively; in combination with ultraviolet radiation treatment and lipid analysis, the system assesses the effect of the sunscreen product against UV stimulated sebum secretion. The method can adapt to sunscreen products of different dosage forms and different action mechanisms, specifically aims at sebaceous gland action, is high in functionality, has the technical advantages of being easy to operate, reliable in result, good in repeatability and the like, and can be used for efficacy evaluation and development optimization of the sunscreen products.

The present invention relates to the use of a stable aqueous silicic acid solution in the preparation of a product for treating acne, wherein a mass concentration of the stable aqueous silicic acid solution is 0.5-2%. A product using the stable aqueous silicic acid solution as an active ingredient can be used for treating acne or for preventing and / or treating sebaceous gland dyshomeostasis. At a mass concentration of 0.5-2%, the product can lighten the color of sebaceous gland plaques, thereby achieving an anti-acne effect. Moreover, the stable aqueous silicic acid solution has a low raw material cost, is environmentally friendly and safe, and can thus be used as a highly therapeutically effective alternative to traditional tretinoin drugs.

Embodiments of the present disclosure disclose a scar organoid and a method for constructing, passaging, cryopreserving and drug screening thereof. The specific implementation of the method comprises: a scar organoid comprising an epidermal cell cluster, fibroblasts and residual skin appendage structures, wherein the residual skin appendage structures are sebaceous gland-like lobular structures. The embodiment can improve the authenticity of cell heterogeneity and drug sensitivity reflecting pathological scars, and improve the accuracy of reacting to the biological characteristics of human scars.

The invention provides a new accelerant for synthesizing lipid by sebaceous gland cells, and the new accelerant for synthesizing lipid by sebaceous gland cells can be used for preparing a skin barrier injury repairing agent and preparing cosmetics with a skin barrier injury repairing function. Therefore, cosmetics for repairing at least one skin barrier injury of skin dryness, skin premature senility, skin aging, skin pruritus and senile sebum deficiency eczema caused by sebaceous gland hypofunction and / or sebum secretion reduction can be developed.

The invention belongs to the technical field of hair care products, and particularly relates to a composite acid gel composition as well as a preparation method and application thereof. The composite acid gel composition disclosed by the invention is prepared from the following components in parts by mass: 1.5 to 2.5 parts of capryloyl salicylic acid, 3.5 to 5 parts of glycolic acid, 0.8 to 1 part of arbutin, 0.05 to 0.1 part of piroctone olamine salt, 8 to 12 parts of a lotus-bacillus subtilis fermentation product, 5 to 6 parts of an emulsifying agent and 70 to 80 parts of water, the arbutin is prepared from alpha-arbutin and beta-arbutin. After capryloyl salicylic acid, glycolic acid, arbutin and a lotus-bacillus subtilis fermentation product are compounded, the composition can go deep into hair follicle sebaceous gland, dredge blocked pores and improve scalp folliculitis; the traditional Chinese medicine composition can effectively treat hair follicle deep blockage, accelerate old and waste cutin shedding, not only can solve the root problem of hair follicle deep blockage, but also can realize surface cutin renewal, and a product prepared from the traditional Chinese medicine composition is green, safe, mild and non-irritant, and can efficiently relieve scalp inflammation and inhibit dandruff.

The invention relates to the technical field of daily cosmetics, in particular to a composition with oil control and dandruff removal effects as well as a preparation method and application thereof, and the composition is prepared from the following raw materials in parts by weight: 5-15 parts of Chinese honey locust, 1.5-8.5 parts of radix sophorae flavescentis, 0.2-3 parts of fructus cnidii and 1-4.8 parts of swertia japonica. Aiming at grease caused by abnormal sebaceous gland regulation, the oil control effect is achieved by utilizing the Chinese honey locust extract and the radix sophorae flavescentis extract; the gleditsia sinensis extract can indirectly reduce excessive secretion of sebum by influencing metabolism of sebaceous gland cells or regulating related hormone levels, so that the purpose of controlling oil is achieved, and the gleditsia sinensis extract is rich in gleditsia sinensis saponin and has good surfactant properties.

The invention discloses an induced differentiation method of sebaceous gland cells, which comprises the following specific steps: adding epidermal stem cells into an induction culture medium, and carrying out induced culture for 5-7 days to obtain the sebaceous gland cells, wherein the adopted induction culture medium is not added with insulin and specifically comprises the following components: 50% of a keratinocyte culture medium, 50% of a sebaceous gland cell culture medium, 1% of antibiotics, 20-40 ng / mL of EGF, 10-40 ng / mL of KGF and 5-20 ng / mL of rosiglitazone. Growth factors EGF and KGF and rosiglitazone are simultaneously added into the induction culture medium, insulin is completely not added, normal division and proliferation of cells are guaranteed, and sebaceous gland cells which are good in growth state and high in differentiation degree are obtained in a short culture period; compared with SZ95, the expression quantities of various sebaceous gland cell markers are similar.