Pharmaceutical composition for treating hyperproliferative skin disease and preparation of pharmaceutical composition

A technology for epidermal hyperproliferation and disease, which is applied in the field of pharmacy, can solve the problems of non-persistence and protein kinase signal transduction system defects, etc., and achieves the effects of simple preparation process, uniform drug release and convenient operation.

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A technology for epidermal hyperproliferation and disease, which is applied in the field of pharmacy, can solve the problems of non-persistence and protein kinase signal transduction system defects, etc., and achieves the effects of simple preparation process, uniform drug release and convenient operation.

CN102988987BActive Publication Date: 2014-06-18XIAN LIBANG PHARMA

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Examples

Experimental program

Comparison scheme

Effect test

Embodiment 1

[0064] Embodiment 1: Contain the emulsifiable paste of 0.001% calcipotriol

[0065] prescription:

[0066]

[0067] method:

[0068] Heat 6g of stearic acid and 3.5g of glyceryl stearate in a water bath until melted, add 0.001g of calcipotriol, 0.1g of tazarotene, 0.1g of betamethasone dipropionate and 0.1g of vitamin E, and stir to dissolve evenly . In addition, heat 70g of PEG-4000 and 10g of PEG-400 in a water bath to 65°C, add 1g of steareth-20, 5g of propylene glycol and 0.1g of ethylparaben, stir evenly, slowly add to the oil phase, stir until the emulsification is complete, add distilled water to 100g, let cool.

Embodiment 2

[0069] Embodiment 2: the cream containing 0.005% calcipotriol

[0070] prescription:

[0071]

[0072] method:

[0073] Heat 6g of stearic acid and 3.5g of glyceryl stearate in a water bath until melted, add 0.005g of calcipotriol, 0.1g of tazarotene, 0.1g of betamethasone dipropionate and 0.1g of vitamin E, and stir to dissolve evenly . In addition, heat 70g of PEG-4000 and 10g of PEG-400 in a water bath to 65°C, add 1g of steareth-20, 5g of propylene glycol and 0.1g of ethylparaben, stir evenly, slowly add to the oil phase, stir until the emulsification is complete, add distilled water to 100g, let cool.

Embodiment 3

[0074] Embodiment 3: Contain the emulsifiable paste of 0.01% calcipotriol

[0075] prescription:

[0076]

[0077] method:

[0078] Heat 6g of stearic acid and 3.5g of glyceryl stearate in a water bath until melted, add 0.01g of calcipotriol, 0.1g of tazarotene, 0.1g of betamethasone dipropionate and 0.1g of vitamin E, and stir to dissolve evenly . In addition, heat 70g of PEG-4000 and 10g of PEG-400 in a water bath to 65°C, add 1g of steareth-20, 5g of propylene glycol and 0.1g of ethylparaben, stir evenly, slowly add to the oil phase, stir until the emulsification is complete, add distilled water to 100g, let cool.

[0079] Part II: The dosage range of tazarotene in ointment

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Abstract

The invention belongs to the field of pharmacy and particularly relates to a pharmaceutical composition for treating hyperproliferative skin disease and a preparation of the pharmaceutical composition. The pharmaceutical composition comprises the following components by weight percent: 0.001-0.01% (W / W) of calcipotriene, 0.05-2% (W / W) of tazarotene and 0.05-2% (W / W) of adrenocortical hormone.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a pharmaceutical composition and a preparation thereof for treating epidermal hyperproliferative diseases. Background technique [0002] Epidermal hyperproliferative diseases refer to a group of diseases and disorders characterized by higher than normal levels of epidermal cell proliferation and often also by abnormal differentiation. Psoriasis is a typical epidermal hyperproliferative disease. It is a chronic inflammatory skin disease characterized by epidermal KC hyperproliferation and granulocyte infiltration. The severity of symptoms varies from small local plaques to the whole body. Clinically, it is divided into four types: vulgar, pustular, arthropathic and erythrodermic, among which the common type is the most common type in clinical practice. The disease affects 2% to 3% of the total population, and is one of the most common autoimmune diseases in the world. It can occur at any ag...

Claims

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Application Information

Patent Timeline

18 Jun 2014

Publication

CN102988987B

IPC: A61K45/00; A61K31/593; A61K31/4436; A61K9/06; A61P17/00; A61P17/06

Inventors: 王汝涛; 陈涛