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Transdermal drug delivery system and method of using the same

A transdermal drug delivery system and skin technology, applied in the field of eyelid disease treatment, can solve the problems of impairing the quality of life of patients, unsightly, and not mentioned

Inactive Publication Date: 2013-12-04
SENJU USA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, although MGD may not threaten vision, it progressively impairs the patient's quality of life
Second, abnormal lipids produced by MGD patients have a negative impact on tear film quality, which creates problems in both discomfort and visual acuity
Third, MGD can lead to meibomian cysts, which can be painful and unsightly for the patient
However, these documents do not mention the method of treating eyelid diseases such as chalazion, blepharitis or meibomian gland dysfunction by administering steroids to patients who need it

Method used

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  • Transdermal drug delivery system and method of using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] By blending 100 parts by weight of hydrogenated rosin ester resin (trade name "Pinecrystal KE311") as a tackifier with 100 parts by weight of styrene-isoprene-styrene block copolymer (trade name " Quintac 3520"), resulting in SIS (Styrene-Isoprene-Styrene) based pressure sensitive adhesives. Dissolve 99.0 w / w% SIS-based pressure-sensitive adhesive (Pinecrystal KE311 / Quintac 3520 ratio 50% / 50% (w / w)) and 1.0 w / w% clobetasol propionate in toluene to A coating liquid having a solids content of 50% by weight was obtained. The coating liquid was applied on a release paper so as to obtain a dry coating thickness of 40 µm. After drying, a support (a polyester film having a thickness of 12 μm) was laminated to provide a patch preparation.

Embodiment 2

[0083] Add 0.005 g of a crosslinking agent (chelate type crosslinking agent; trade name "NISSETSU CK-401") and 0.05 g of clobetasol to 12.363 g (solid: 4.945 g) of an acrylic pressure-sensitive adhesive [trade name "NISSETSU PE-300"; alkyl (meth)acrylate-vinyl acetate copolymer; pressure-sensitive adhesive solution (ethyl acetate / toluene mixed solvent) with a solid content of 40% by weight] to prepare The coating liquid had a concentration of 57.3% by weight. The coating liquid was applied on a release paper so as to obtain a dry coating thickness of 80 µm. After drying, a support (a polyester film having a thickness of 12 μm) was laminated to provide a patch preparation.

Embodiment 3

[0085] By using 40.5 g of styrene-isoprene-styrene block copolymer (trade name "SIS5000") as a rubber elastic substance and 40.5 g of terpene resin (trade name "YS Resin 1150N") as a tackifier and 10 g of clobetasol propionate were dissolved in 150 g of toluene to obtain a pressure-sensitive adhesive solution (coating liquid) having a solid content of 40% by weight. The coating liquid was applied on a release paper so as to obtain a dry coating thickness of 40 µm. After drying, a support (a polyester film having a thickness of 12 μm) was laminated to provide a patch preparation.

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Abstract

A transdermal drug delivery system comprising a steroid as an active agent, wherein the steroid may be clobetasol propionate, betamethasone dipropionate, amcinonide, or loteprednol etabonate. The transdermal drug delivery system also comprises a pressure-sensitive adhesive layer and a support, wherein the steroid is present in the pressure-sensitive adhesive layer, and wherein the pressure-sensitive adhesive layer is provided on a support. The transdermal drug delivery system may be applied onto the eyelid of a patient in need thereof, in order to treat a disease of the eyelid, such as chalazion, blepharitis or meibomian gland dysfunction.

Description

field of invention [0001] The present invention relates to a transdermal delivery system and a method for treating eyelid diseases by applying said transdermal delivery system to the eyelid of a patient in need thereof. Background of the invention [0002] Transdermal drug delivery systems, also known as transdermal patches or skin patches, are drug-adhesive patches that are placed on the skin for transdermal absorption to deliver drugs through the skin, which is the process of absorption through topical application through the skin. The transdermal drug delivery system can deliver the drug systemically, ie, through the bloodstream, or it can deliver the drug locally by placement at the desired treatment site. [0003] Eyelid disorders, such as chalazion, blepharitis, meibomian gland dysfunction, allergic conjunctivitis, vernal keratoconjunctivitis, and atopic keratoconjunctivitis, are often thought to be due to inflammation. Although steroid therapy is available for treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M35/00
CPCA61K9/0048A61K9/7069A61K9/00A61K9/7061A61K31/56A61K31/573A61K31/58A61K9/0014A61K9/7053A61P27/02A61P29/00
Inventor 小河贵裕礒胁明治
Owner SENJU USA
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