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Aerosol medicine composition containing beclomethasone dipropionate

A beclomethasone and aerosol technology, applied in the field of drug preparation, can solve the problems of insufficient drug administration, adverse reactions, drug inhomogeneity, etc.

Inactive Publication Date: 2016-11-23
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The difference between the suspension and the dry powder inhaler is that the most prone problem is the unevenness of the drug after placement, especially as a drug that needs to be used for a long time and can be fatal, such as asthma. It is even more problematic, that is to say, at a certain stage, the dosage of the drug is more than the labeled amount, and at a certain stage, the dosage of the drug

Method used

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  • Aerosol medicine composition containing beclomethasone dipropionate
  • Aerosol medicine composition containing beclomethasone dipropionate
  • Aerosol medicine composition containing beclomethasone dipropionate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Beclomethasone dipropionate was dissolved in ethanol, filtered, and the filtrate was spray-dried and micronized to make the D90 particle size reach 2 μm.

[0023] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 68°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0025] Beclomethasone dipropionate was dissolved in ethanol, filtered, and the filtrate was spray-dried and micronized to make the D90 particle size reach 4 μm.

[0026] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

Embodiment 3

[0028] Beclomethasone dipropionate was dissolved in ethanol, filtered, and the filtrate was spray-dried to make the D90 particle size reach 5 μm.

[0029] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention relates to an inhalant aerosol suspension, which is an inhalable aerosol suspension medicine composition that is prepared from beclomethasone dipropionate and amino acids, especially leucine or phenylalanine. The aerosol suspension maintains suspension stability better and is also improved in homogeneity and convenience in usage.

Description

Technical field: [0001] The invention relates to a beclomethasone dipropionate inhalation suspension aerosol for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc., and also relates to a preparation method of the medicine. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. At present, the drugs for the treatment of asthma and other lung diseases mainly...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/573A61K47/16A61P11/00A61P11/06
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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