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Beclomethasone dipropionate emulsifiable paste

A technology of beclomethasone dipropionate and clomethasone cream, applied in the direction of ointment delivery, emulsion delivery, medical preparations of non-active ingredients, etc., which can solve problems such as death, blood calcium drop, convulsions, etc.

Active Publication Date: 2014-04-09
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it should be pointed out that patients with lead poisoning who should be treated with edetate calcium and sodium, especially children, may cause serious decrease in blood calcium, convulsions and even death due to misuse of edetate disodium

Method used

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  • Beclomethasone dipropionate emulsifiable paste
  • Beclomethasone dipropionate emulsifiable paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0031] Beclomethasone dipropionate 0.25g, dimethyl sulfoxide 15g, white petrolatum 100g, stearyl alcohol 90g, liquid paraffin 50g,

[0032] Pingpingjia A-20 50g, glycerin 50g, ethyl p-hydroxybenzoate 1g,

[0033] Add calcium sodium edetate 0.1g to 1000g with water for injection,

[0034] Accurately weighed according to the above ratio, the cream preparation process is as follows:

[0035] 1) Mix edetate, ethyl p-hydroxybenzoate, glycerin and distilled water and heat to 70°C;

[0036] 2) Dissolve the prescribed amount of beclomethasone dipropionate in the prescribed amount of dimethyl sulfoxide;

[0037] 3) Heat stearyl alcohol, white vaseline, Pingpingjia A-20, and liquid paraffin in the prescribed amount to 80°C, slowly add the mixture obtained in step 1) and stir quickly, then add beclomethasone dimethasone dipropionate in step 3) Sulfoxide solution, mixed, condensed into a paste. Cream content of beclomethasone dipropionate 0.025%

Embodiment 1-2

[0039] According to the recipe and process of Example 1-1, the amount of calcium sodium edetate was changed to 0.25g.

Embodiment 1-3

[0041] According to the recipe and process of Example 1-1, the amount of calcium sodium edetate was changed to 1 g.

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Abstract

The invention discloses beclomethasone dipropionate emulsifiable paste. The beclomethasone dipropionate emulsifiable paste comprises beclomethasone dipropionate adopted as the active component, an oil-phase component, a humectant, an emulsifier, an aseptic and water, and is characterized by also comprising edetate calcium disodium.

Description

technical field [0001] The invention relates to a cream of beclomethasone dipropionate. Background technique [0002] Beclomethasone dipropionate (CAS: 5534-09-8, Beclometasone Dipropionate) is the 17,21-dipropionate of beclomethasone, which belongs to the adrenal cortex hormone drugs. External application can shrink the dermal capillaries and inhibit the development of epidermal cells. Proliferation or regeneration, inhibit the regeneration of fibroblasts in connective tissue, stabilize intracellular lysosomal membranes, prevent tissue damage caused by the release of lysosomal enzymes, and have strong anti-inflammatory and anti-allergic effects. For allergic dermatitis, atopic dermatitis, contact dermatitis, seborrheic dermatitis, eczema, pruritus, psoriasis, neurodermatitis, etc. However, long-term or large-scale application can cause skin atrophy and telangiectasia, acne-like dermatitis, folliculitis, perioral dermatitis, and increased susceptibility to infection. Even ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/573A61K47/18A61K47/44A61P17/00
Inventor 赵琳孙亮陈松
Owner TIANJIN JINYAO GRP
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