Composite scaffold material and preparation method and application thereof

Abstract

The invention relates to the technical field of medicine, in particular to a composite scaffold material and a preparation method and application thereof. The provided composite scaffold material includes a charged fiber skeleton material, and the fiber skeleton material is coated with alternately superimposed positive charge biocompatibility materials and negative charge biocompatibility materials through electrostatic attraction. As the fiber skeleton material is coated with the alternately superimposed positive charge biocompatibility materials and negative charge biocompatibility materialsthrough electrostatic attraction, the provided composite scaffold material overcomes the defects of an existing scaffold material, such as poor hydrophilicity, poor biocompatibility, poor histocyte adhesion ability and weak biological induction activity, has better applicability when used in tissue adhesion, sealing, leaking stoppage, hemostasis, isolation, repair and adhesion prevention and thelike, and can be used for preparation of carriers (such as sustained release carriers) of drugs, tissue engineering scaffold materials and the like, and thus the composite scaffold material can be widely used.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composite support material and its preparation method and application. Background technique [0002] Common absorbable scaffold materials implanted in the body, such as degradable polymer materials polylactic-co-glycolic acid (PLGA), polylactic acid (PLA), polycaprolactone (PCL) electrospun scaffolds, have poor hydrophilicity , poor biocompatibility, weak tissue cell adhesion and biological induction activity, so they cannot well induce and promote the regeneration and repair of defective tissue, and these scaffolds shrink greatly in body fluids to further affect the use effect. Another example is the use of acellular matrix materials, the immunogenicity is not completely removed, which will cause immune rejection; the use of biopolymer materials, such as collagen sponges, although biocompatibility is good, but the mechanical properties such as mechanical strength are poor, an...

AI Technical Summary

Problems solved by technology

[0002] Common absorbable scaffold materials implanted in the body, such as degradable polymer materials polylactic-co-glycolic acid (PLGA), polylactic acid (PLA), polycaprolactone (PCL) electrospun scaffolds, have poor hydrophilicity , poor biocompatibility, weak tissue cell adhesion and biological induction activity, so it cannot well induce and promote the regeneration and repair of defective tissue, and these scaffolds shrink greatly in body fluids to further affect the use effect

Another example is the use of acellular matrix materials, the immunogenicity is not completely removed, which will cause immune rejection; the use of biopolymer materials, such as collagen sponges, although biocompatibility is good, but the mechanical properties such as mechanical strength are poor, and the structure is easy to collapse. Implanted into the human body, the degradation rate is too fast, and the tissue has not been fully repaired when the degradation is complete; the cast film of polymer material is used, the surface is dense, it is difficult for host cells to migrate into the material, and they can only adhere to the surface of the material, resulting in a decline in the repair effect

Most tissue repair regeneration scaffolds are prone to fracture and delamination, resulting in separation during use or volume shrinkage after implantation, which affects the therapeutic effect; most tissue repair patches are cross-linked with cross-linking agents, which can improve mechanical properties after cross-linking. Prolong the degradation time, but the use of too much cross-linking agent not only has certain tissue toxicity, but also easily leads to the formation of calcification

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