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Preparation method and application of conductive hydrogel capable of slowly releasing drugs and factors

A conductive hydrogel and sustained-release drug technology, which can be used in pharmaceutical formulations, drug delivery, medical preparations with inactive ingredients, etc. Increase the effect of immobilizing bioactive growth factors, stabilizing metal-organic framework structures, and improving electrochemical activity

Inactive Publication Date: 2019-01-25
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the in vivo environment is relatively complex, and the drug contained in the metal-organic framework is prone to structural disintegration during the process of delivery to the lesion, resulting in drug loss, making the drug concentration in the lesion too low to achieve the desired curative effect; on the other hand , metal organic framework materials have a unique pore structure, which can buffer the volume expansion of electrodes, increase the contact area between substrate and product and electrolyte, and shorten the electron transfer process; metal organic framework materials have great potential in the field of bioelectrodes; but metal Organic framework materials inherently have poor electrical conductivity, which limits their applications
[0003] The existing metal organic framework materials have the following problems: metal organic framework drug loading is easy to lose when transported in vivo, resulting in low drug concentration in the lesion; the poor conductivity and stability of metal organic framework materials limit their application in bioelectrodes. and other applications

Method used

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  • Preparation method and application of conductive hydrogel capable of slowly releasing drugs and factors
  • Preparation method and application of conductive hydrogel capable of slowly releasing drugs and factors

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preparation example Construction

[0027] The preparation method of the conductive hydrogel capable of sustained release of medicines and factors comprises the following steps:

[0028] Step 1: Prepare a conductive polymer monomer solution with a mass concentration of 0.04-2%, add an oxidizing agent, stir and react at 0-5°C for 4-10 days, perform centrifugal cleaning several times after sufficient reaction, and obtain a conductive polymer polymer material; the mass ratio of the conductive polymer monomer to the oxidizing agent is 1:1~20; the oxidizing agent is one of ferric chloride, ferric nitrate, ferric sulfate and ammonium ferric sulfate; the conductive polymer monomer is pyrrole monomer, One of aniline monomers, thiophene monomers and 5-carboxyindole monomers.

[0029] Step 2: Prepare a dopamine aqueous solution with a concentration of 0.05-10 mg / mL, adjust the pH to 8-13 with ammonia water or trisaminomethane buffer solution; add the conductive polymer obtained in step 1, and stir at room temperature for ...

Embodiment 1

[0039] A preparation method of conductive hydrogel, comprising the following steps:

[0040] A, preparation of polydopamine / poly 3,4-ethylenedioxythiophene complex

[0041]Dissolve 266 μL of 3,4-ethylenedioxythiophene monomer in 30 mL of absolute ethanol to obtain a solution with a mass concentration of 1.5% of 3,4-ethylenedioxythiophene monomer; add 7 g of trichloride to the above solution iron, stirred and reacted at 0-5°C for 5 days; the solution after the above reaction was centrifuged and washed several times with deionized water to obtain poly-3,4-ethylenedioxythiophene particles; dopamine was dissolved in deionized water to obtain A dopamine solution with a concentration of 0.5 mg / mL, the pH of the above solution was adjusted to 8.5 with ammonia water; then, poly-3,4-ethylenedioxythiophene particles were added to the above solution, stirred at room temperature for 12 hours, and washed several times to obtain poly Dopamine / poly-3,4-ethylenedioxythiophene complex.

[00...

Embodiment 2

[0050] A, preparation of polydopamine / polypyrrole complex

[0051] Dissolve 190 μL of pyrrole monomer in 40 mL of absolute ethanol to obtain a solution with a mass concentration of 0.58% pyrrole monomer; add 5 g of iron sulfate to the above solution, and stir and react at 0-5°C for 3 days; The final solution was centrifuged and washed 3 times with deionized water to obtain polypyrrole particles; dopamine was dissolved in deionized water to obtain a solution with a dopamine concentration of 0.4 mg / mL, and the pH of the above solution was adjusted to 8.5 with trisaminomethane buffer. ; Then, add polypyrrole particles to the above solution, stir at room temperature for 12 hours, and wash several times to obtain a polydopamine / polypyrrole complex.

[0052] B, Preparation of ZIF-7 / polydopamine / polypyrrole complex

[0053] Dissolve zinc acetate in N,N-dimethylformamide to obtain a solution with a mass concentration of zinc acetate of 2.15%; dissolve benzimidazole in methanol to obt...

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Abstract

The invention discloses a preparation method and application of a conductive hydrogel capable of slowly releasing drugs and factors. The preparation method comprises the following steps: step 1, a conductive macromolecular monomer solution is prepared, an oxidant is added, and after sufficient reaction, a conductive macromolecular polymer is obtained; step 2, a concentrated aqueous dopamine solution is prepared, the conductive macromolecular polymer obtained in step 1 is added, and after sufficient reaction, a polydopamine / conductive macromolecular polymer compound is obtained; step 3, a metalion salt solution and an organic ligand solution are prepared; step 4, the polydopamine / conductive macromolecular polymer compound is added into the metal ion salt solution, and after uniform mixing,the organic ligand solution is added; and reaction is sufficiently carried out; step 5, the metal-organic framework / polydopamine / conductive macromolecular polymer compound is added into a monomer ordouble-bond biomacromolecular solution; and after additive is added, the needed hydrogel is formed by polymerization. The conductive hydrogel has excellent conductivity and electrochemical activity, and can be used in the preparation of drug carriers and biological electrodes.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method and application of a conductive hydrogel capable of sustained release of drugs and factors. Background technique [0002] In recent years, metal-organic frameworks have been widely used as drug carriers because of their advantages such as large surface area, adjustable pore size, moderate pore volume, and high porosity; high specific surface area can load biomacromolecules, and large pore size can encapsulate different types of drugs , and the drug loading is large. However, the in vivo environment is relatively complex, and the drug contained in the metal-organic framework is prone to structural disintegration during the process of delivery to the lesion, resulting in drug loss, making the drug concentration in the lesion too low to achieve the desired curative effect; on the other hand , metal organic framework materials have a unique pore structure, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L87/00C08L79/04C08L65/00C08L79/02A61K9/00A61K9/06A61K31/43A61K31/4409A61K31/573A61K31/737A61K38/18A61K38/30A61K47/02A61K47/32A61K47/34
CPCA61K9/0009A61K9/06A61K31/43A61K31/4409A61K31/573A61K31/737A61K38/1875A61K38/30A61K47/02A61K47/32A61K47/34C08J3/075C08J2365/00C08J2379/02C08J2379/04C08J2387/00C08J2465/00C08J2479/02C08J2479/04C08J2487/00
Inventor 鲁雄黄自强甘东林闫力维王笑
Owner SOUTHWEST JIAOTONG UNIV
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