The invention discloses a preparation method and application of a conductive hydrogel capable of slowly releasing drugs and factors. The preparation method comprises the following steps: step 1, a conductive macromolecular
monomer solution is prepared, an oxidant is added, and after sufficient reaction, a conductive macromolecular
polymer is obtained; step 2, a concentrated aqueous
dopamine solution is prepared, the conductive macromolecular
polymer obtained in step 1 is added, and after sufficient reaction, a polydopamine / conductive macromolecular
polymer compound is obtained; step 3, a metalion
salt solution and an organic ligand solution are prepared; step 4, the polydopamine / conductive macromolecular polymer compound is added into the
metal ion salt solution, and after uniform mixing,the organic ligand solution is added; and reaction is sufficiently carried out; step 5, the
metal-organic framework / polydopamine / conductive macromolecular polymer compound is added into a
monomer ordouble-bond biomacromolecular solution; and after additive is added, the needed hydrogel is formed by
polymerization. The conductive hydrogel has excellent
conductivity and electrochemical activity, and can be used in the preparation of
drug carriers and biological electrodes.