Preparation method of porous silicon hydrogel interpenetrating network (IPN) membrane

An interpenetrating network and hydrogel technology, which is applied in the field of preparation of silicon hydrogel interpenetrating network film, can solve the problem of limited content of hydrogel components, and is suitable for large-scale production, simple production equipment, and good biological performance. Compatibility effect

Inactive Publication Date: 2011-01-12
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of hydrogel components that can be introduced by this method is very limited

Method used

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  • Preparation method of porous silicon hydrogel interpenetrating network (IPN) membrane
  • Preparation method of porous silicon hydrogel interpenetrating network (IPN) membrane
  • Preparation method of porous silicon hydrogel interpenetrating network (IPN) membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh 0.3g PEG and dissolve in 300ml 0.1M CaCl 2 and 0.1M Na 2 CO 3 The solution is recorded as solution A and solution B respectively; 1.2g SDS is added to solution B and mixed thoroughly; the prepared solution A is quickly added to solution B, stirred for 1min and left to age at 25°C; the obtained CaCO 3 The microsphere precipitate was repeatedly washed with water 5 times, and dried for later use;

[0040] Prepare the aluminum-zirconium coupling agent with a concentration of 2% aqueous solution, and take the CaCO obtained in the first step 3 Microsphere powder was added to the solution; after ultrasonic vibration treatment, the resulting suspension was poured into a three-necked flask, heated to 40°C and continued to stir at a constant temperature for 1 hour; filtered, dried, and ground to obtain the surface-modified CaCO 3 Template particles;

[0041] Mix 4g PDMS, 0.4g TEOS, 0.12g stannous octoate, dissolve in 2.67g isopropanol, add 0.4g CaCO 3The particles wer...

Embodiment 2

[0045] Weigh 0.2g PEG and dissolve in 100ml 0.05M CaCl 2 and 0.05M Na 2 CO 3 The solutions are recorded as solution A and solution B respectively; 2g of SDS was added to solution B and mixed thoroughly; the prepared solution A was quickly added to solution B, stirred for 1min and left to age at 20°C; the obtained CaCO 3 The microsphere precipitate was repeatedly washed with water 4 times, and dried for later use;

[0046] Prepare the aluminum-zirconium coupling agent with a concentration of 1% aqueous solution, and take the CaCO obtained in the first step 3 Add microsphere powder into the solution; after ultrasonic vibration treatment, pour the resulting suspension into a three-necked flask, raise the temperature to 50°C and continue stirring at constant temperature for 1.5h; filter, dry, and grind to obtain the surface-modified CaCO 3 Template particles;

[0047] Mix 4g PDMS, 0.2g TEOS, 0.04g stannous octoate, dissolve in 1.6g isopropanol, add 0.2g CaCO 3 The particles w...

Embodiment 3

[0051] Weigh 0.4g PEG and dissolve in 400ml 0.3M CaCl 2 and 0.3M Na 2 CO 3 In the solution, record it as solution A and solution B respectively; add 1g SDS to solution B and mix thoroughly; quickly add the prepared solution A to solution B, stir for 2min and stand at 30°C for aging; the obtained CaCO 3 The microsphere precipitate was repeatedly washed with water 6 times, and dried for later use;

[0052] Prepare the aluminum-zirconium coupling agent with a concentration of 4% aqueous solution, and take the CaCO obtained in the first step 3 Add microsphere powder into the solution; after ultrasonic vibration treatment, pour the resulting suspension into a three-necked flask, raise the temperature to 60°C and continue to stir at a constant temperature for 2 hours; filter, dry, and grind to obtain the surface-modified CaCO 3 Template particles;

[0053] Mix 4g PDMS, 0.8g TEOS, 0.2g stannous octoate, dissolve in 3.2g isopropanol, add 0.8g CaCO 3 The particles were fully stirr...

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Abstract

The invention relates to a preparation method of a porous silicon hydrogel interpenetrating network (IPN) membrane, which comprises the following steps: (1) respectively dissolving polyethylene glycol in CaCl2 solution and Na2CO3 solution, adding sodium lauryl sulfate to one solution, and adding the sodium lauryl sulfate to the other solution; (2) adding CaCO3 microspheric powder to aluminum-zirconium coupling agent aqueous solution; (3) dissolving dimethyl polysiloxane, tetraethyl orthosilicate and stannous octoate in isopropanol, and adding CaCO3 template particles to obtain a PDMS first network membrane; (4) adding isopropanol to a mixed liquor of hydroxyethyl methacrylate (HEMA), azoisobutyronitrile and N,N'-dimethylene diacrylamide; and soaking the first network membrane in the mixed liquor to obtain PDMS/PHEMA IPN; and (5) soaking the first network membrane in dilute hydrochloric acid, and carrying out oscillating with ultrasonic wave to obtain the porous silicon hydrogel IPN membrane. The method is simple and suitable for industrial production; and the IPN membrane has an interpenetrating porous structure, and has the advantages of favorable water-retaining property and high drug loading capacity.

Description

technical field [0001] The invention belongs to the field of preparation of silicon hydrogel interpenetrating network (IPN) membranes, in particular to a preparation method of porous silicon hydrogel interpenetrating network (IPN) membranes. Background technique [0002] Polydimethylsiloxane (PDMS) material has good biocompatibility, stability and oxygen permeability, therefore, it has a good application prospect as a biomedical material, but due to its own hydrophobic characteristics as a long-term plant Adding materials will cause some adverse effects. In order to make PDMS more widely used in various fields such as tissue filling and drug release, it is an effective way to improve its surface wettability and permeability to water-soluble substances through the introduction of hydrophilic components. [0003] Modification of PDMS by hydrogel can be achieved by the following methods: (1) grafting hydrogel on the surface of PDMS; (2) silicone hydrogel copolymer system; (3) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L83/04C08L33/14C08F220/28C08F2/44C08K9/02C08K3/26C08J3/075C08J5/18C08J9/26A61L27/26A61L27/56A61L27/52A61K47/34A61K47/32
Inventor 胡祖明汤琦于俊荣陈蕾诸静
Owner DONGHUA UNIV
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