The invention provides a method of a Co-SBA-16 mesoporous molecule sieve used for directly hydroxylating the benzene to be combined in phenol, and relates to a Co-SBA-16 synthesis method. A purpose of the present invention is to mainly solve problems of harsh synthesis conditions, difficult control, long period and low catalysis activity of the existing cobalt-loaded SBA-16 type mesoporous silicon molecule sieve. The method comprises: 1, adding F127 and anhydrous ethanol to a bottle A, and sequentially carrying out an ultrasound treatment and stirring; 2, adding cobalt nitrate, anhydrous ethanol, tetraethyl orthosilicate and HCl to a bottle B, and sequentially carrying out an ultrasound treatment and stirring; 3, adding HCl to the stirred solution in the bottle A, stirring, adding 1,3,5-trimethylbenzene, and stirring; 4, after stirring in the bottle B, heating, and continuously stirring; and 5, completely transferring the solution in the bottle A to the bottle B, stirring, placing in a baking oven, pouring to a watch glass, evaporating the solvent, taking the solid substance, and baking to obtain the finished product. The method is used for directly hydroxylating to be combined in phenol.