Method for preparing unsymmetrical compound sponge

A composite sponge, asymmetric technology, applied in the field of preparation of asymmetric composite sponge, can solve the problems of limited functional properties, limited hemostatic effect, etc., achieve the effects of large antibacterial and antibacterial effects, convenient clinical use, and rich sources of raw materials

Inactive Publication Date: 2008-05-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most medical sponges are composite sponges made of a single material. Due to the defects of the material itself, the functional properties of this product are limited to a certain extent.
There are also researchers who mix chitosan and gelatin to make asymmetric sponges or add polyvinyl alcohol on the basis of the two to make asymmetric sponges. The efficacy of these so-called asymmetric sponges basically depends on chitosan and gelatin. limited hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In the first step, sodium carboxymethylcellulose with a degree of substitution of 1.0 is prepared into a 1% solution with water, chitosan with a degree of deacetylation of 60% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared into a concentration of 1% solution.

[0023] In the second step, the three solutions of sodium carboxymethyl cellulose, gelatin and chitosan were measured in a volume ratio of 1:2:2, and the total volume was maintained at 30 mL.

[0024] Step 3 Mix the above three solutions, stir evenly, and let stand to defoam.

[0025] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0026] The fifth step is to put all the above-mentioned sponge products into a 50mL watch glass filled with 0.1% carbodiimide solution by mass percentage, seal it with plastic wrap, place it on a decolorizing sh...

Embodiment 2

[0029] The first step is prepared into a 1% solution of sodium carboxymethylcellulose with a degree of substitution of 0.75 with water, chitosan with a degree of deacetylation of 80% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared into a concentration of 1% solution.

[0030] In the second step, the three solutions of sodium carboxymethyl cellulose, gelatin and chitosan were measured in a volume ratio of 1:0.5:3, and the total volume was maintained at 30 mL.

[0031] The third step is to mix the above three solutions, stir evenly, and let stand to defoam.

[0032] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0033] The fifth step is to put all the above-mentioned sponge products into a 40mL watch glass filled with a carbodiimide solution with a mass percentage of 0.05%, seal it with a plastic wrap, p...

Embodiment 3

[0036] The first step is prepared into a 1% solution of sodium carboxymethylcellulose with a degree of substitution of 1.2 with water, chitosan with a degree of deacetylation of 75% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared with a concentration of 1% solution.

[0037] In the second step, the three solutions of sodium carboxymethylcellulose, gelatin and chitosan were measured in a ratio of 1:2:1 by volume, and the total volume was maintained at 30 mL.

[0038] The third step is to mix the above three solutions, stir evenly, and let stand to defoam.

[0039] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0040] The fifth step is to put all the above-mentioned sponge products into a 30mL watch glass filled with 0.2% carbodiimide solution by mass percentage, seal it with plastic wrap, place it on a ...

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Abstract

The invention discloses a preparation method of an asymmetric composite sponge. The method comprises preparing sodium carboxymethyl cellulose into a solution with a concentration of 1% with distilled water, and preparing chitosan with dilute acetic acid into a solution with a concentration of 1%. The gelatin is made into a solution with a concentration of 1% with warm water; sodium carboxymethyl cellulose, gelatin and chitosan are measured according to the ratio of 1:0.5~3:0.5~3 by volume, left standing for defoaming, poured into In the membrane device, the sponge product is obtained by vacuum freeze-drying; put the sponge product into a watch glass of carbodiimide solution, seal it with a plastic wrap, place it on a decolorizing shaker, vibrate for 24 hours, add distilled water, and seal the mouth with a plastic wrap , placed on a shaker, shaken for 1 h, and repeated this operation three times. The cross-linked sponge is pre-frozen twice and dried to obtain an asymmetric composite sponge. The product prepared by the invention has strong hemostatic effect, is convenient for clinical use, and has good water absorption and water retention properties and drug loading performance.

Description

technical field [0001] The invention relates to a preparation method of an asymmetrical composite sponge, in particular to mixing carboxymethyl cellulose, chitosan and gelatin by a freeze-drying method to prepare a sponge product with porous, elastic, hemostatic and drug-loading functions. Background technique [0002] After debridement of large-area skin injuries caused by burns and ulcers, skin grafting or artificial skin is required to cover the wound surface to prevent the loss of electrolytes and proteins caused by the loss of tissue fluid and body fluid, prevent bacterial invasion and cause infection, and promote wound tissue healing. At present, the commonly used artificial skin in clinical practice at home and abroad mainly includes pigskin, collagen membrane or collagen sponge polyurethane membrane. Because pigskin is easy to delaminate with the skin, it has poor compatibility with wound tissue, which is not conducive to the regeneration of epidermal tissue cells; t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28
Inventor 何小维罗志刚罗发兴扶雄
Owner SOUTH CHINA UNIV OF TECH
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