52results about How to "With sustained release effect" patented technology

The invention belongs to the field of pharmaceutical preparations, and relates to activated neutrophil membrane coated neutrophil like nanoparticles and a preparation method. According to the activated neutrophil membrane coated like nanoparticles and the preparation method disclosed by the invention, a polymer, namely a poly(lactic-co-glycolic acid) copolymer PLGA, or a poly(lactic acid) copolymer PLA, or a polycaprolactone copolymer PCL is used as a material for preparing nanoparticles, the nanoparticles are used as kernels and are used for coating and loading model medicines, natural activated neutrophil membranes as a shell are used for coating the surfaces of the nanoparticles, and an activated neutrophil membrane coated biodegradable neutrophil like particle nanometer carrier system is prepared. Experiments in vivo and vitro indicate that the like particle nanometer carrier system can have the characteristics of being high in targetability and high in efficiency in accordance with a like treatment system for circulating tumor cells and micrometastases, provides new thought for individual and precision treatment and has higher clinical practice significance.

The invention provides a method for preparing a flower organic slow-release fertilizer by utilizing municipal sludge, comprising the following steps of: airing and dewatering raw sludge, crushing, adding microbes and dilatants, stack retting and fermenting, baking, crushing, sieving, adding inorganic fertilizers, pelleting, baking for the second time, cooling, sieving and metering packaging. The method for preparing the flower organic slow-release fertilizer by utilizing the municipal sludge has simple production process and low production cost and comprehensively utilizes municipal sewage to treat generated sludge, i.e. turns harm into good and changes waste into valuable, thereby realizing sludge reduction, harmlessness and reclamation. The invention provides an effective technical method and way.

The invention relates to dinotefuran granules and a preparation method thereof. The dinotefuran granules have effective components of dinotefuran and the balance of pesticide adjuvant and carriers, wherein the mass percent of the dinotefuran in the dinotefuran granules is 0.01-10%. The invention also discloses the preparation method of the dinotefuran granules. The dinotefuran granules provided by the invention are suitable for controlling pests of crops such as rice, wheat, vegetables, fruit trees, etc.

The invention discloses a novel efficient biochar-based water-retaining dedicated crop fertilizer, prepared from, by weight, 100-300 parts of urea, 350-500 parts of monoammonium phosphate, 100-300 parts of potassium chloride, 0-15 parts of calcium magnesium phosphate fertilizer, 40-100 parts of biochar, 0-30 parts of EDTA (ethylene diamine tetraacetic acid) chelated trace elements, 0-15 parts of polyglutamic acid, and 0-100 parts of additives. The preparation process of the fertilizer is simple, the fertilizer contains biochar, polyglutamic acid and various trace nutrients and can improve soil environmental conditions, land utilization and land maintenance are combined, crop yield is increased, and the fertilizer has high efficiency and zero pollution.

The invention discloses a hydroxycamptothecin slow-release microsphere and a preparation method thereof, relates to an anti-tumor pharmaceutical preparation and provides a hydroxycamptothecin slow-release microsphere and a preparation method thereof with long time of continuous drug release, stable drug release and high drug utilization; a carrier is polylactic acid, anti-cancer drug of hydroxycamptothecin is packed in the carrier and a modifying layer of water soluble derivative of chitosan is arranged on the surface of the carrier; the hydroxycamptothecin and the polylactic acid are dissolved in an organic solvent so as to obtain solution A; polyvinyl alcohol solution with the concentration of 0.5 percent to 5 percent is prepared and sodium dodecyl sulfate is added to prepare mixed solution B with the concentration of 0.5 percent to 1 percent; the solution A is transferred into a disperse phase container of a film emulsifier, the mixed solution B is added into a continuous phase container, a water suction pump is started to lead the continuous phase to be cycled, a mobile phase is collected, a certain pressure is maintained and a pressure indicating value which is operated to the film emulsifier is reduced to 0kPa. The collected mobile phase is centrifugated, precipitation is collected and freeze-dried to obtain the unmodified drug-carrying microsphere and then the surface modifying of the microsphere is carried out.

The invention relates to a drug compound playing the role of diminishing inflammation, alleviating pain and eliminating fever and being used for treating arthritis, odynolysis and pyrexia caused by upper respiratory tract infection, and particularly relates to a drug compound oral pharmaceutical formulation adopting nimesulide as the ingredient and being prepared jointly with the medicinal carrier used as the stroma. The drug compound aims to supplement the deficiency of the prior oral nimesulide pharmaceutical formulation and provide a drug compound oral formulation, sustained-release nimesulide dropping pill which has high bioavailability, controllable release time, long-acting effect, reduced frequency of drug taking for a patient, low cost and absence of contamination during the production. The sustained-release nimesulide dropping pill adopts nimesulide as the chemical ingredient and is prepared jointly with the medicinal carriers of hydrophilic frame ingredients and hydrophobic frame ingredients used as the stroma.

The invention relates to a chlorfenapyr and cartap granular preparation comprising the active ingredients of chlorfenapyr and cartap and the balance of pesticide adjuvants. The ratio of the chlorfenapyr to the cartap is 1:1-1:50 in parts by mass; and the total mass of the chlorfenapyr and the cartap accounts for 0.01%-10% of the composite. The granular preparation disclosed by the invention is suitable for preventing and treating rice pests and has the advantages of safety, environmental protection and long pesticide effect lasting period.

The invention relates to the field of organic-inorganic composite materials, and in particular relates to a slow-release double-effect pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating MCPA-(2-Methyl-4-chlorophenoxyacetic acid radical) into a hydrotalcite precursor, intercalating chlorpyrifos into the hydrotalcite precursor, and finallytreating the hydrotalcite precursor in a mixed solution containing hydrogen peroxide, n-propanol and water to obtain a slow-release double-effect pesticide; the chemical formula is: [(M<2 +>) 1-x (M<3 +>) x (OH) 2) x +( MCPA-)x (CPF) y.mH2O, wherein x = 0.25-0.33, y = 0.08-0.10, m = 3-6, m is the number of interlayer crystalline water molecules, M<2 +> is a divalent metal ion, M<3 +> is a trivalent metal ion, MCPA-is 2-Methyl-4-chlorophenoxyacetic acid radical, and CPF is chlorpyrifos. The slow-release double-effect pesticide of the invention has stable intercalation structure, can release the MCPA-and the chlorpyrifos l for a long time, and plays a slow-release effect.

The invention relates to the field of organic-inorganic composite materials, in particular to a sustained-release phoxim pesticide and a preparation method thereof. The method includes: low-release phoxim pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating a naphthylacetic acid group into a hydrotalcite precursor; and then intercalating phoxim into the hydrotalcite precursor to obtain phoxim/naphthylacetic acid intercalated hydrotalcite; and putting the hydrotalcite into a mixed solution containing hydrogen peroxide, ethanol and waterfor ultrasonic treatment, thus obtaining the sustained-release phoxim pesticide, the chemical formula of which is shown as [(M<2+>)1-x(M3<+>)x(OH)2]<x+>(NAA<->)x(Phoxim)y.mH2O, wherein x=0.25-0.33, y=0.04-0.05, m=3-6, m is the number of interlayer crystal water molecules, M<2+> is a divalent metal ion, M<3+> is a trivalent metal ion, and Phoxim is phoxim. The sustained-release phoxim pesticide provided by the invention has a stable intercalation structure, can release phoxim for a long time and reach a sustained-release effect, and the preparation method is easy to realize.

The invention discloses an antivirus drug compound and particularly relates to an oral pharmaceutical preparation adopting famciclovir as the ingredient and being prepared jointly with the medicinal carrier used as the stroma. The antivirus drug compound aims to supplement the deficiency of the prior antivirus oral pharmaceutical preparation and provide a sustained-release famciclovir dropping pill which has high bioavailability, fast effect, high drug content, low frequency of drug taking, full release, convenient drug taking, low cost and absence of contamination during the production. The sustained-release famciclovir dropping pill adopts famciclovir as the ingredient and is prepared jointly with the medicinal carriers of mixing hydrophilic frame ingredients and hydrophobic frame ingredients as the stroma.

The invention discloses a PLGA-PEG-ZOL drug-loaded nano-material specifically targeting bone tissues. The shell surface of PLGA is coupled with zoledronic acid, so the obtained PLGA has the in vivo targeting ability to actively target the bone tissues, and the PLGA has a treatment effect on osteoporosis and osteolysis, so the obtained PLGA can be used as a drug carrier shell to encapsulate a therapeutic drug in order to delay the initial burst release dose of the drug, prolong the half-life of the drug and increase the stability and the solubility of the drug, and enables nanoparticles to havea certain sustained release effect and a passive targeting property, that is, the PLGA-PEG-ZOL drug-loaded nano-material can be loaded with different drugs and target the drugs to the bone tissues according to different treatment demands in order to increase the drug concentration of the drugs in bone tissues, thereby the nano-material has the potential to be suitable for multiple skeletal systemdiseases. The invention also discloses a preparation method of the drug-loaded nanomaterial. The preparation method has the advantages of simple process, and easiness in operation.

The invention provides an insect-repelling waterborne wood coating. The insect-repelling waterborne wood coating is prepared from components in parts by weight as follows: 20-25 parts of a styrene-acrylic emulsion, 8-10 parts of an insect-repelling agent, 1-2 parts of a dispersant, 0.8-1.5 parts of a defoamer, 1-3 parts of a coalescing agent, 0.5-1.5 parts of benzophenone and 59-66 parts of water; the insect-repelling agent is chitosan with pyrethrin supported. A preparation method of the insect-repelling waterborne wood coating comprises steps as follows: pyrethrin is dissolved in ethanol, a pyrethrin-ethanol solution is prepared, chitosan is dissolved in a 3wt% acetic acid water solution, and a chitosan water solution is prepared, the pyrethrin-ethanol solution and the chitosan water solution are mixed uniformly, spray drying is performed, and the chitosan with pyrethrin supported is obtained. The provided insect-repelling waterborne wood coating adopts the chitosan with pyrethrin supported as the insect-repelling agent and has the characteristics of being low in toxicity, safe, efficient and high in stability, besides, pyrethrin has a slow release efficacy, and the insect-repelling time of the coating can be prolonged.

The invention relates to a preparation method of a coated type muscovado sugar modified nano-iron groundwater remediation agent and belongs to the field of groundwater remediation. According to the preparation method, firstly, a nano-iron material is modified with muscovado sugar, then the modified nano-iron surface is coated with a polymer film layer with an emulsion polymerization method, and the coated type muscovado sugar modified nano-iron groundwater remediation agent is prepared. According to the prepared groundwater remediation agent, nano-iron is taken as a functional core, the nano-iron surface is modified with the muscovado sugar, so that the dispersity of nano-iron is improved, and the problem that a traditional nano-iron material is prone to agglomeration is solved; modified nano-iron is coated with acrylic resin and is prevented from being directly contacted with air accordingly, the defects that nano-iron combusts spontaneously due to direct exposure to the air and is oxidized when contacted with the air, and surface activity is damaged because of generation of an iron oxide film on the surface are overcome, and the coated type muscovado sugar modified nano-iron groundwater remediation agent is a novel and efficient groundwater remediation agent and has broad application prospect.

The invention discloses a drug containing sustained-release ornidazole drug and used for treating infections of trichmonad, amoeba, giardia and anaerobic organism in gynecopathy as well as the preparation method thereof. The drug aims to provide a sustained-release ornidazole dropping pill formulation which has excellent curative effect, low toxic and side effects, broad-spectrum antibacterium, safer use, low frequency of drug taking and long effective hours and is prepared by adopting the solid dispersion technology, thereby thoroughly changing the defects existing in conventional oral formulations from the drug structure. The sustained-release ornidazole dropping pill adopts ornidazole as the ingredient and is prepared jointly with the medicinal carrier used as the stroma.

The invention discloses an environment-friendly slow-release snow-melting agent, a preparation method thereof and application of the snow-melting agent in a micro-surfacing mixture, and aims to solve the technical problems that an existing snow-melting agent is large in side effect, and an existing micro-surfacing mixture is single in pavement performance and insufficient in wear resistance and high-temperature stability. The environment-friendly slow-release snow-melting agent is prepared from the graphene microchips, the white carbon black, the sodium carbonate, the sodium acetate, the calcium acetate, the surface treating agent and the like, is used for modifying the emulsified asphalt and is applied to a micro-surfacing mixture, has the effects of repairing an old pavement, preventing a new pavement from cracking and actively melting ice and snow, and is excellent in pavement performance; in the whole service period, the ice and snow removing effect, the high and low temperature performance and the abrasion resistance are good, and good economic benefits and social benefits are achieved.

The invention belongs to the technical field of organic-inorganic composite materials, and particularly relates to a slow-release bactericide suitable for a hospital environment and a preparation method of the slow-release bactericide. The slow-release bactericide suitable for the hospital environment includes apramycin, dodecylbenzene sulfonate and benzene sulfonate intercalated hydrotalcite. The preparation method comprises the following steps: firstly preparing a hydrotalcite precursor, then intercalating dodecylbenzene sulfonate and benzene sulfonate into the hydrotalcite precursor according to a certain proportion to obviously enlarge the interlayer spacing of hydrotalcite, then mixing the hydrotalcite with an apramycin aqueous solution, and diffusing apramycin into the interlayer of the hydrotalcite to obtain apramycin intercalated hydrotalcite, namely, the slow-release bactericide. According to the invention, the effect of adjusting the apramycin slow release rate can be achieved by adjusting the ratio of dodecylbenzene sulfonate radicals to benzene sulfonate radicals in layers.

The present invention relates to a production device and a production method of a double slow release high dispersion medicinal fertilizer; the production device includes a urea solution pipeline, theurea solution pipeline is connected with a granulation system through a third valve, a fourth flow meter, a first inlet and an outlet of a pipeline mixer, the second inlet of the pipeline mixer is connected with a medicinal fertilizer emulsifying device; the medicinal fertilizer emulsifying device includes a pesticide tank which is connected with one side of the top of an emulsifying tank, a solvent tank is connected with the other side of the top of the emulsifying tank, an emulsifying tank motor is arranged at the middle of the top of the emulsifying tank, an emulsifying tank outlet is connected with the inner chamber of a nozzle through a solution pump, the nozzle is arranged on the lower middle part of a fluidized bed reactor, a middle powder inlet of the fluidized bed reactor is connected with a fertilizer carrier tank by a powder pump, a material outlet at the bottom of the fluidized bed reactor is connected with the second inlet of the pipeline mixer, a pesticide can be evenlydistributed inside a fertilizer without direct contact with the fertilizer, the compatibility effect of the pesticide and the fertilizer is overcome, and the purpose of unified double slow release ofthe pesticide and the fertilizer can be achieved.