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Slow-release bactericide suitable for hospital environment and preparation method oflow-release bactericide

A slow-release, fungicide technology, applied in the field of slow-release fungicide and its preparation

Active Publication Date: 2021-11-12
ZIBO VOCATIONAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no published literatures and patents on apramycin intercalation hydrotalcite in China

Method used

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  • Slow-release bactericide suitable for hospital environment and preparation method oflow-release bactericide
  • Slow-release bactericide suitable for hospital environment and preparation method oflow-release bactericide
  • Slow-release bactericide suitable for hospital environment and preparation method oflow-release bactericide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Weigh 29.75g Zn(NO 3 ) 2 ﹒ 6H 2 O and 18.76g Al(NO 3 ) 3 ﹒ 9H 2 O dissolved in 200ml to remove CO 2 Mixed salt solution was prepared with water, another 8.0g NaOH was dissolved in 100ml to remove CO 2 Prepare alkaline solution in water, N at room temperature 2 Protection Use the double-drop method to add the salt solution and the alkali solution into the four-neck flask, and stir vigorously. Adjust the pH value to 7 with 0.1mol / L NaOH solution. The resulting slurry was crystallized at 60°C for 72h, centrifuged and washed 3 times; the sample was taken out and dried at 50°C for 48h for characterization, and ZnAl-NO 3 -LDHs, whose molar ratio Zn 2+ / Al 3+ =2.

[0047] (2) Dissolve 17.4g sodium dodecylbenzenesulfonate and 9.0g sodium benzenesulfonate in 150mL to remove CO 2 After the deionized water was transferred to the four-necked bottle, 10g of hydrotalcite precursor ZnAl-NO was added 3 -LDHs,N 2 Protected and heated to 50°C, reacted for 48h under st...

Embodiment 2

[0051] (1) Weigh 25.63g Mg(NO 3 ) 2 ﹒ 6H 2 O and 18.76g Al(NO 3 ) 3 ﹒ 9H 2 O dissolved in 200ml to remove CO 2 Mixed salt solution was prepared with water, another 8.0g NaOH was dissolved in 200ml to remove CO 2 Prepare alkaline solution in water, N at room temperature 2 Protection Use the double-drop method to add the salt solution and the alkali solution into the four-neck flask, and stir vigorously. Adjust the pH value to 10 with 1.0mol / L NaOH solution. The obtained slurry was crystallized at 80°C for 12h, and the product was washed by centrifugation for 5 times; the sample was taken out and dried at 70°C for 20h for characterization, and MgAl-NO 3 -LDHs, whose molar ratio Mg 2+ / Al 3+ =2.

[0052](2) Dissolve 7.0g sodium dodecylbenzenesulfonate and 18.0g sodium benzenesulfonate in 150mL to remove CO 2 After the deionized water was transferred to the four-necked bottle, 10g of hydrotalcite precursor MgAl-NO was added 3 -LDHs, N 2 Protected and heated to 70°C...

Embodiment 3

[0056] (1) Weigh 29.08g Ni(NO 3 ) 2 ﹒ 6H 2 O and 18.76g Al(NO 3 ) 3 ﹒ 9H 2 O dissolved in 250ml to remove CO 2 Mixed salt solution was prepared with water, another 8.0g NaOH was dissolved in 200ml to remove CO 2 Prepare alkaline solution in water, N at room temperature 2 Protection Use the double-drop method to add the salt solution and the alkali solution into the four-neck flask, and stir vigorously. Adjust the pH value to 7 with 3mol / L NaOH solution. The resulting slurry was crystallized at 70°C for 36h, and the product was centrifuged and washed 4 times; the sample was taken out and dried at 60°C for 36h for characterization, and NiAl-NO 3 -LDHs, whose molar ratio Zn 2+ / Al 3+ =2.

[0057] (2) Dissolve 34.8g sodium dodecylbenzenesulfonate and 3.6g sodium benzenesulfonate in 150mL to remove CO 2 deionized water into the four-necked bottle, and then add 10g of hydrotalcite precursor NiAl-NO 3 -LDHs, N 2 Protected and heated to 60°C, reacted for 36h under stir...

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Abstract

The invention belongs to the technical field of organic-inorganic composite materials, and particularly relates to a slow-release bactericide suitable for a hospital environment and a preparation method of the slow-release bactericide. The slow-release bactericide suitable for the hospital environment includes apramycin, dodecylbenzene sulfonate and benzene sulfonate intercalated hydrotalcite. The preparation method comprises the following steps: firstly preparing a hydrotalcite precursor, then intercalating dodecylbenzene sulfonate and benzene sulfonate into the hydrotalcite precursor according to a certain proportion to obviously enlarge the interlayer spacing of hydrotalcite, then mixing the hydrotalcite with an apramycin aqueous solution, and diffusing apramycin into the interlayer of the hydrotalcite to obtain apramycin intercalated hydrotalcite, namely, the slow-release bactericide. According to the invention, the effect of adjusting the apramycin slow release rate can be achieved by adjusting the ratio of dodecylbenzene sulfonate radicals to benzene sulfonate radicals in layers.

Description

technical field [0001] The invention belongs to the technical field of organic-inorganic composite materials, and in particular relates to a slow-release bactericide suitable for hospital environments and a preparation method thereof. Background technique [0002] Nosocomial infection, also known as nosocomial infection or hospital-acquired infection, refers to the infection acquired by patients, staff and escorts in the hospital. The hospital is a place where all kinds of patients gather, and it is easy to breed all kinds of bacteria. Nosocomial infection has become a prominent public health problem facing the hospital. Therefore, it is of extremely important practical significance to do a good job of disinfecting bacteria in public places in the hospital. At present, the hospital environment mainly uses hydrogen peroxide disinfectant and ultraviolet rays to inhibit and disinfect bacteria. Hydrogen peroxide disinfectant can kill intestinal pathogenic bacteria, pyogenic coc...

Claims

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Application Information

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IPC IPC(8): A01N25/08A01N43/90A01P1/00
CPCA01N25/08A01N43/90Y02A50/30
Inventor 赵强
Owner ZIBO VOCATIONAL INST
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