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A kind of cysteamine hydrochloride premix and preparation method thereof

A technology of cysteamine hydrochloride and premix, which is applied in the direction of anti-toxic agents, pharmaceutical formulas, medical preparations of non-active ingredients, etc., and can solve the problem of affecting the use effect of products, affecting the gastrointestinal function of animals, easy oxidation and moisture absorption, etc. problem, to achieve the effect of reducing the probability of moisture absorption and oxidation, reducing the probability of moisture absorption, and reducing irritation

Active Publication Date: 2018-11-02
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cysteamine is very easy to oxidize and absorb moisture during processing and storage, which affects the use effect of the product. At the same time, because cysteamine hydrochloride is easily oxidized into disulfide in the air, it will stimulate the stomach wall in the stomach and affect the animal's health. gastrointestinal function

Method used

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  • A kind of cysteamine hydrochloride premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) 12g chitosan and 5g sodium hydroxymethyl cellulose are added to 100g 3wt% aqueous acetic acid solution, after mixing uniformly, 35g cysteamine hydrochloride is added thereto, and 50.8g cysteamine salt is obtained through spray drying Salt slow-release granules.

[0024] (2) After mixing 50g of cysteamine hydrochloride slow-release granules, 5g of hygroscopic agent, 12g of polyethylene glycol, 3g of cyclamate, 30g of montmorillonite and 30g of 30wt% ethanol aqueous solution, extruding and granulating through an extruder ;

[0025] (3) drying the wet granules obtained in step (2), adopting 20 mesh and 80 mesh grading and sieving sieves to obtain a cysteamine hydrochloride premix with a particle size of 20-80 mesh, and making the particle size less than 20 mesh and greater than 80 mesh The granules are returned to step (2) for re-granulation.

Embodiment 2

[0027] (1) 10g chitosan and 6g sodium hydroxymethyl cellulose are added to 100g 3wt% aqueous acetic acid solution, after mixing uniformly, 46.4g cysteamine hydrochloride is added thereto, and 61g cysteamine salt is obtained through spray drying Salt slow-release granules.

[0028] (2) After mixing 20g of cysteamine hydrochloride slow-release granules, 3g of hygroscopic agent, 15g of polyethylene glycol, 2g of cyclamate, 60g of montmorillonite and 35g of 30wt% ethanol aqueous solution, extruding and granulating through an extruder ;

[0029] (3) drying the wet granules obtained in step (2), adopting 20 mesh and 80 mesh grading and sieving sieves to obtain a cysteamine hydrochloride premix with a particle size of 20-80 mesh, and making the particle size less than 20 mesh and greater than 80 mesh The granules are returned to step (2) for re-granulation.

Embodiment 3

[0031] (1) 15g chitosan and 4g sodium hydroxymethyl cellulose are added to 100g 3wt% aqueous acetic acid solution, after mixing uniformly, 23.8g cysteamine hydrochloride is added thereto, and 40g cysteamine salt is obtained through spray drying Salt slow-release granules.

[0032] (2) After mixing 40g cysteamine hydrochloride slow-release granules, 4g hygroscopic agent, 8g polyethylene glycol, 1g cyclamate, 47g montmorillonite and 40g 30wt% ethanol aqueous solution, extrude and granulate through an extruder ;

[0033] (3) drying the wet granules obtained in step (2), adopting 20 mesh and 80 mesh grading and sieving sieves to obtain a cysteamine hydrochloride premix with a particle size of 20-80 mesh, and making the particle size less than 20 mesh and greater than 80 mesh The granules are returned to step (2) for re-granulation.

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Abstract

The invention provides a mercaptamine premix. The mercaptamine premix is prepared from, by weight, 30-60 parts of mercaptamine slow-release particles, 3-5 parts of moisture absorbent, 8-15 parts of polyethylene glycol, 1-3 parts of sodium cyclamate and 40-55 parts of montmorillonite. A preparation method of the mercaptamine slow-release particles includes the following steps that chitosan and carboxymethyl cellulose sodium are dissolved in 3wt% aqueous acetic acid to prepare a solution A, mercaptamine is added into the solution A, and after the materials are stirred and mixed to be uniform, the mercaptamine slow-release particles are prepared through spray drying. The surface of mercaptamine is coated with chitosan and carboxymethyl cellulose sodium through a spray-drying method, a slow-release protective film is formed, the moisture absorption oxidation probability of mercaptamine is effectively reduced, the slow-release effect is achieved, and irritation of mercaptamine to the stomachs and intestines of animals is relieved.

Description

technical field [0001] The invention relates to a veterinary drug premix, in particular to a cysteamine hydrochloride premix and a preparation method thereof. Background technique [0002] Cysteamine, also known as β-mercaptoethylamine, is a white crystalline powder with a melting point of 99-100°C and a slight odor. It is easily soluble in water and alcohol and has an alkaline reaction. It is easy to deliquescence, and its aqueous solution will become dark when it contacts with metal ions. Cysteamine molecules have mercapto groups, which are easily oxidized into disulfides in the air, and its hydrochloride is usually used as its substitute. Cysteamine hydrochloride is chemically stable, solid at room temperature, strong in hygroscopicity, easy to oxidize at high temperature, and has a melting point of 70.2-70.7°C. Since cysteamine can deplete somatostatin in the body, a large number of studies have confirmed that cysteamine and its hydrochloride are ideal substances that c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/145A61K47/36A61K47/38A61K47/02A61P5/00A61P1/14A61P39/00A61P31/04A23K20/10A23K20/26A23K20/28A23K50/30A23K40/10A23K40/30
CPCA61K9/0002A61K9/1611A61K9/1652A61K31/145
Inventor 聂月美王贤玉张丽佳邱洪左纯子
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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