Compound flavescent sophora root sustained-release dropping pill and preparation thereof
A technology for sustained-release dropping pills and compound Sophora flavescens, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Problems such as low dissolution rate, to avoid gastrointestinal irritation symptoms, improve bioavailability, and accelerate dissolution and absorption
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[0034] Now with several groups of specific examples, the preparation method of the compound Sophora flavescens sustained-release dropping pills of the present invention is further described.
[0035] First group:
[0036] Based on the total weight of 100g, weigh the matrix PEG6000 20%, PEG4000 40%, stearic acid 10%, glyceryl monostearate 10%, raw material extract 20%; prepared according to the above preparation method, the condensate used is dimethyl base silicone oil.
[0037] The obtained product has a 2-hour cumulative release percentage of 35-53%, a 6-hour cumulative release percentage of 65-86%, a 10-hour cumulative release percentage of 78-96%, good hardness and roundness.
[0038] Second Group:
[0039] Based on the total weight of 100g, weigh the matrix PEG6000 15%, PEG4000 20%, polyvinylpyrrolidone 5%, stearic acid 20%, glyceryl monostearate 10%, stearyl alcohol 5%, raw material extraction 25%; according to the above preparation method, the condensate used is simet...
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