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Compound flavescent sophora root sustained-release dropping pill and preparation thereof

A technology for sustained-release dropping pills and compound Sophora flavescens, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Problems such as low dissolution rate, to avoid gastrointestinal irritation symptoms, improve bioavailability, and accelerate dissolution and absorption

Inactive Publication Date: 2008-12-17
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In addition, due to preparation technology and other reasons, for example, most oral preparations of drugs have long dissolution time, low dissolution rate, poor absorption, frequent administration, hepatic first-pass effect and low bioavailability after taking. problems, thus affecting the efficacy of the drug, and directly affecting the therapeutic effect
At the same time, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0034] Now with several groups of specific examples, the preparation method of the compound Sophora flavescens sustained-release dropping pills of the present invention is further described.

[0035] First group:

[0036] Based on the total weight of 100g, weigh the matrix PEG6000 20%, PEG4000 40%, stearic acid 10%, glyceryl monostearate 10%, raw material extract 20%; prepared according to the above preparation method, the condensate used is dimethyl base silicone oil.

[0037] The obtained product has a 2-hour cumulative release percentage of 35-53%, a 6-hour cumulative release percentage of 65-86%, a 10-hour cumulative release percentage of 78-96%, good hardness and roundness.

[0038] Second Group:

[0039] Based on the total weight of 100g, weigh the matrix PEG6000 15%, PEG4000 20%, polyvinylpyrrolidone 5%, stearic acid 20%, glyceryl monostearate 10%, stearyl alcohol 5%, raw material extraction 25%; according to the above preparation method, the condensate used is simet...

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PUM

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Abstract

The invention discloses a medicinal composition which can clear heat, promote diuresis, remove heat from the blood and toxic substances, eliminate stagnation and relieve pains and is used for curing disease such as hemorrhage of cancer pain, in particular to a slow releasing oral preparation of the medicinal composition, which is prepared by using Chinese medicines of radices sophorae flavescentis and Rhizoma Hterosmilacis as raw materials and a pharmaceutical carrier as a substrate. The invention aims at supplementing the deficiencies of existing injection and oral pharmaceutical preparations and providing an oral compound radices sophorae flavescentis slow releasing drop pill which is suitable for family use and has the advantages of high biological availability, less medicine-taking times, long effective time, instant effect, small toxic and side-effect, low manufacturing and medical treatment cost and low price. The compound radices sophorae flavescentis slow releasing drop pill, which the invention relates to, is prepared by taking the Chinese medicines radices sophorae flavescentis and Rhizoma Hterosmilacis as the raw materials and taking the pharmaceutical carrier as the substrate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a compound flavescens sustained-release dripping pill and a preparation method thereof. technical background [0002] Compound Matrine Injection is composed of Sophora flavescens and Baituling. The main chemical components of the injection are oxymatrine, matrine, sophocarpine, matrine flavonoids, and saponins. It has the functions of clearing away heat and promoting dampness, cooling blood and detoxifying, dispelling stagnation and relieving pain. Compound Kushen Injection has the functions of stopping bleeding, relieving pain, and inhibiting the proliferation of cancer cells. At the same time, it can also improve hematopoietic function and increase the body's immunity. It provides a reliable means for the rehabilitation of cancer patients and effectively improves the quality of life of patients. The development of this drug broke the h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K9/22A61K47/32A61K47/34A61K47/38A61P35/00A61P29/00A61P7/04A61K47/10
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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