Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof

Abstract

The invention relates to a drug compound which has the efficacies of dispelling wind, removing dampness, stimulating the circulation of blood, relaxing muscles and joints, subsiding swellings and relieving pain, and is used for treating rheumatic diseases. The drug compound aims to supplement the deficiencies of the prior oral pharmaceutical preparation used for treating the symptoms of rheumatoid arthritis (The symptoms are that joints are swollen, painful and hard to straighten, the limbs are chill tender and cold weather worsens the situation, and waist and legs lack strength or chill and fever jumble.) and provide a combined oral pharmaceutical preparation, thunder god vine total terpene slow-release dropping pill which has the advantages that the bioavailability is high, the effect is rapid, the release time is long, the taking frequency is low, toxic and side effects are small, the medicine content is high, the dose is small, the dose is precise, the medicine-taking is convenient, the price is low and the portability is available. The dropping pill is prepared according to a definite ingredient constitution by adopting the thunder god vine extractive as the ingredient and by adopting a hydrophilic framework material and a hydrophobic framework material as the stroma.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a medicine that has the functions of expelling wind and dehumidification, relaxing tendons, reducing swelling and relieving pain, and is used for treating joint swelling and pain caused by cold-damp invasion, blood stasis blocking collaterals, unfavorable flexion and extension, aversion to cold and cold limbs. Aggravated by cold, weak waist and knees, or alternating cold and heat; rheumatoid arthritis, see the pharmaceutical composition for those with the above symptoms, especially a kind of total terpenes of Tripterygium wilfordii prepared from the extract of Tripterygium wilfordii Sustained-release drop pill preparation. Background technique [0002] Tripterygium wilfordii total terpene tablets prepared according to the formula and preparation method given in the national drug standard WS-10715 (ZD-0715)-2002, is a kind of medicine that has the functions of expelling wind and da...

AI Technical Summary

Problems solved by technology

[0012] For patients with the above-mentioned symptoms, there is a need for a drug that has a long effective time and a rapid effect. Due to reasons such as preparation technology, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicines, all exist after taking. Long dissolution time, low dissolution rate, poor absorption, unstable blood drug concentration, insufficient drug release, many patients taking the drug, hepatic first-pass effect and low bioavailability, etc., which affect the efficacy of the drug, and also directly affect the therapeutic effect

[0013] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also give some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.