Fibrauretine sustained-release dropping pills and preparation method thereof

Abstract

The invention relates to a fibrauretine sustained-release pill having the antibacterial and antiphlogistic action as well as a preparation method thereof. The invention aims at providing a medicine(the fibrauretine sustained-release pill) which takes fibrauretine as effective constituent and has the antibacterial and antiphlogistic action; compared with the existing oral preparation at the market, the pill has the advantages that: 1. the deficiency of the existing oral pharmaceutical preparation is made up and a pill preparation which has high bioavailability and rapid effect is provided; 2. after being made into the sustained-release pill, the medication content is high, the medicine release is controllable, the time of taking the medicine by the patient is few, the medicine taking is convenient, the price is low; 3. the production equipment is simple and no pollution is generated in the production. The fibrauretine sustained-release pill related by the invention takes the fibrauretine which is the effective constituent of calamus margaritae of traditional Chinese medicine as raw material and can be prepared together with medicated carrier that takes hydrophilic framework material and hydrophobic framework material as stroma.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a palmatine sustained-release dripping pill with antibacterial and anti-inflammatory effects and a preparation method thereof. Background technique [0002] Huangteng, also known as Huanglian, Rhubarb, is the root and stem of Huangteng, a plant of the family Fangjiaceae. Cold in nature, sweet in taste, bitter in taste, poisonous, enters the two meridians of the heart and liver. "Compendium of Materia Medica" records "Huangteng, born in Lingnan. It looks like self-defense. The natives often take this vine, and even if they eat poisonous food, they will naturally not hair." Detumescence. Control heat depression, constipation, dysentery, stone water, sore carbuncle, petechiae, red eyes." "Guangxi Chinese Herbal Medicine" said "clearing heart-fire, diuresis. Treatment of dysentery, acute gastroenteritis, acute tonsillitis, pharyngitis , conjunctivitis, tuberculosis, sores, boils, a...

AI Technical Summary

Problems solved by technology

The preparations made of palmetine include palmatine tablets, palmetine injection, etc. Although they have been used in a large number of clinical applications since they were launched, they have achieved good therapeutic effects. The dissolution rate in medium is slow, stickiness and agglomeration are prone to occur during the dissolution process, and redissolution is difficult. Oral preparations such as tablets are slowly absorbed in the digestive tract due to the large molecular weight of the active ingredient, and their bioavailability is low. Injection preparations It is not as convenient as oral preparations in clinical use, especially the stability and safety of traditional Chinese medicine injections are not as good as oral preparations, and quality problems such as crystallization or precipitation often occur