Ornidazole sustained-release dropping pill and preparation method thereof

A technology for sustained-release dropping pills and ornidazole, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Problems such as allergic reactions or adverse reactions

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, after capsules and tablets are taken, they are absorbed into the blood through the gastrointestinal tract, and then reach the lesion from the blood. It is also prone to nausea, vomiting, glossitis, anorexia, upper abdominal pain, diarrhea and other gastrointestinal adverse reactions
In addition, after tablets and capsules are taken, there are problems such as low dissolution rate, many times of taking medicine, short effective time, hepatic and intestinal first-pass effect and low bioavailability, which affect the efficacy of the drug and directly affect the effect of treatment.
[0004] Injections are often prone to allergic reactions or adverse reactions, etc., but also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

Method used

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  • Ornidazole sustained-release dropping pill and preparation method thereof

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Comparison scheme
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Embodiment Construction

[0026] First group:

[0027] Based on the total weight of 100g, weigh the matrix PEG1500 20%, PEG6000 10%, PEG4000 40%, stearic acid 10%, glyceryl monostearate 10%, raw material ornidazole 10%; place the matrix in a heating container Heat and stir to make it melt, add the corresponding proportion of ornidazole, stir fully, and under the condition of heat preservation, drop the molten or mixed liquid medicine into the condensation column filled with simethicone oil, wherein, the The temperature is 55°C, the temperature of the upper part of the condensate is 30°C, and the temperature of the bottom is -4°C; take it out after forming.

[0028] The obtained product has a 2-hour cumulative release percentage of 35-55%, a 6-hour cumulative release percentage of 65-83%, a 10-hour cumulative release percentage of 73-96%, good hardness and roundness.

[0029] Second Group:

[0030] Based on the total weight of 100g, weigh 30% of the matrix PEG1500, 30% of PEG4000, 10% of polyvinylpyrr...

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Abstract

The invention discloses a drug containing sustained-release ornidazole drug and used for treating infections of trichmonad, amoeba, giardia and anaerobic organism in gynecopathy as well as the preparation method thereof. The drug aims to provide a sustained-release ornidazole dropping pill formulation which has excellent curative effect, low toxic and side effects, broad-spectrum antibacterium, safer use, low frequency of drug taking and long effective hours and is prepared by adopting the solid dispersion technology, thereby thoroughly changing the defects existing in conventional oral formulations from the drug structure. The sustained-release ornidazole dropping pill adopts ornidazole as the ingredient and is prepared jointly with the medicinal carrier used as the stroma.

Description

technical field [0001] The invention belongs to the field of western medicine preparations, in particular to a drug containing ornidazole slow-release drug for treating trichomonas, amoeba, giardia and anaerobic infection in gynecological diseases and a preparation method thereof. Background technique [0002] Trichomonas, amoeba, giardia, anaerobic infection is a common clinical disease. The high incidence and worldwide distribution of amoebiasis and giardiasis make them the main parasitic diseases of humans; trichomoniasis is one of the most common non-viral transmissible diseases. About 2.5 to 3 million women are affected each year in the United States, and 180 million people worldwide are exposed to the disease. Since the successful development of metronidazole for the treatment of such diseases, humans have been trying to find ways to find better efficacy and fewer side effects of drugs. Therefore, tinidazole and ornidazole have been developed. [0003] Ornidazole is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4164A61K47/32A61K47/34A61K47/38A61K47/44A61P15/02A61P33/02A61P31/04A61K47/10
CPCY02A50/30
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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