Ornidazole sustained-release dropping pill and preparation method thereof

Abstract

The invention discloses a drug containing sustained-release ornidazole drug and used for treating infections of trichmonad, amoeba, giardia and anaerobic organism in gynecopathy as well as the preparation method thereof. The drug aims to provide a sustained-release ornidazole dropping pill formulation which has excellent curative effect, low toxic and side effects, broad-spectrum antibacterium, safer use, low frequency of drug taking and long effective hours and is prepared by adopting the solid dispersion technology, thereby thoroughly changing the defects existing in conventional oral formulations from the drug structure. The sustained-release ornidazole dropping pill adopts ornidazole as the ingredient and is prepared jointly with the medicinal carrier used as the stroma.

Description

technical field [0001] The invention belongs to the field of western medicine preparations, in particular to a drug containing ornidazole slow-release drug for treating trichomonas, amoeba, giardia and anaerobic infection in gynecological diseases and a preparation method thereof. Background technique [0002] Trichomonas, amoeba, giardia, anaerobic infection is a common clinical disease. The high incidence and worldwide distribution of amoebiasis and giardiasis make them the main parasitic diseases of humans; trichomoniasis is one of the most common non-viral transmissible diseases. About 2.5 to 3 million women are affected each year in the United States, and 180 million people worldwide are exposed to the disease. Since the successful development of metronidazole for the treatment of such diseases, humans have been trying to find ways to find better efficacy and fewer side effects of drugs. Therefore, tinidazole and ornidazole have been developed. [0003] Ornidazole is...

AI Technical Summary

Problems solved by technology

For example, after capsules and tablets are taken, they are absorbed into the blood through the gastrointestinal tract, and then reach the lesion from the blood. It is also prone to nausea, vomiting, glossitis, anorexia, upper abdominal pain, diarrhea and other gastrointestinal adverse reactions

In addition, after tablets and capsules are taken, there are problems such as low dissolution rate, many times of taking medicine, short effective time, hepatic and intestinal first-pass effect and low bioavailability, which affect the efficacy of the drug and directly affect the effect of treatment.

[0004] Injections are often prone to allergic reactions or adverse reactions, etc., but also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

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