Medicine-carried black phosphorus shell glycan composite nanospheres and preparation method and application thereof

A technology of nanospheres and chitosan, applied in the direction of drug combination, pharmaceutical formula, active ingredient of phosphorus compounds, etc., can solve the problems of insufficient ability and difficult effective penetration of drugs, and achieve enhanced antibacterial efficacy, reduce adverse toxic and side effects, and the scope of application wide effect

Active Publication Date: 2019-08-06
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the delivery system disclosed in the prior art has insufficient ability to penetrate the physiological barrier of the human body, and it is difficult for the drug to penetrate effectively. Therefore, it is very meaningful to develop a treatment method that can efficiently break through the mucus layer of the respiratory tract and the biofilm barrier of pathogens

Method used

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  • Medicine-carried black phosphorus shell glycan composite nanospheres and preparation method and application thereof
  • Medicine-carried black phosphorus shell glycan composite nanospheres and preparation method and application thereof
  • Medicine-carried black phosphorus shell glycan composite nanospheres and preparation method and application thereof

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Experimental program
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Embodiment 1

[0080] This embodiment provides a drug-loaded black phosphorus chitosan composite nanosphere, the drug-loaded black phosphorus chitosan composite nanosphere is a shell with polyethylene glycol modified on the surface and loaded with black phosphorus quantum dots and drugs Glycan Nanospheres. Its preparation method is:

[0081] (1) Grind block black phosphorus with a particle size of 70 μm in a vacuum environment and disperse it in a mixed solvent of N-methylpyrrolidone and dimethylformamide, and mix the dispersion with a concentration of 1.5 mg / mL with N- Mix methylpyrrolidone and sodium hydroxide, then heat the mixture at 140°C for 12h, cool to 25°C, centrifuge, collect the supernatant, and obtain black phosphorus quantum dot dispersion;

[0082] (2) Prepare a 1% acetic acid solution with a chitosan concentration of 2 mg / mL, adjust the pH to 4.5, filter in turn using 0.45 μm and 0.22 μm filter membranes, and mix it with black phosphorus quantum dot dispersion, medicine and t...

Embodiment 2

[0085] This embodiment provides a drug-loaded black phosphorus chitosan composite nanosphere, the drug-loaded black phosphorus chitosan composite nanosphere is a shell with polyethylene glycol modified on the surface and loaded with black phosphorus quantum dots and drugs Glycan Nanospheres. Its preparation method is:

[0086] (1) Disperse in N-methylpyrrolidone after grinding the massive black phosphorus with a particle size of 50 μm in a vacuum environment, and mix the dispersion with a concentration of 1 mg / mL with N-methylpyrrolidone and sodium hydroxide, Then the mixture was heated at 120°C for 18h, cooled to 20°C, centrifuged, and the supernatant was collected to obtain a black phosphorus quantum dot dispersion;

[0087] (2) Prepare a 1% acetic acid solution with a chitosan concentration of 1 mg / mL, adjust the pH to 4, filter in turn using 0.45 μm and 0.22 μm filter membranes, and mix it with black phosphorus quantum dot dispersion, medicine and tripolyphosphoric acid ...

Embodiment 3

[0090] This embodiment provides a drug-loaded black phosphorus chitosan composite nanosphere, the drug-loaded black phosphorus chitosan composite nanosphere is a shell with polyethylene glycol modified on the surface and loaded with black phosphorus quantum dots and drugs Glycan Nanospheres. Its preparation method is:

[0091] (1) Grind block black phosphorus with a particle size of 100 μm in a vacuum environment and disperse it in a mixed solvent of N-methylpyrrolidone, dimethylformamide and tetrahydrofuran, and mix the dispersion with a concentration of 2 mg / mL with N - Methylpyrrolidone and sodium hydroxide are mixed, then the mixed solution is heated at 160°C for 6h, cooled to 30°C, centrifuged, and the supernatant is collected to obtain a black phosphorus quantum dot dispersion;

[0092] (2) Prepare a 2% acetic acid solution with a chitosan concentration of 3 mg / mL, adjust the pH to 5, filter in turn using 0.45 μm and 0.22 μm filter membranes, and mix it with black phosp...

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Abstract

The invention relates to medicine-carried black phosphorus shell glycan composite nanospheres and a preparation method and application thereof. The medicine-carried black phosphorus shell glycan composite nanospheres are glycan nanospheres of which the surface modified with polyethylene glycol, and which are packed with black phosphorus quantum dots and medicines. The black phosphorus quantum dots, glycan and polyethylene glycol are creatively combined, the advantage of synergy is exerted, and the protective screen of a respiratory tract mucous layer and a pathogenic bacteria biomembrane can be efficiently broken through, so that the nanospheres have favorable capacity of carrying and delivering medicines, and the nanospheres are broad in application range. According to the nanospheres, various treatment medicines can be loaded, the treatment effect of the medicines can be increased, and the bad toxic and side effects can be reduced. Besides, the nanospheres have favorable biocompatibility. The medicine-carried black phosphorus shell glycan composite nanospheres provide a new strategy for treatment of respiratory diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a drug-loaded black phosphorus-chitosan composite nanosphere and a preparation method and application thereof. Background technique [0002] In recent years, with the aggravation of air pollution and the increase of smoking population, the incidence of respiratory diseases has become more and more serious. Among them, COPD is a chronic respiratory disease with high incidence and difficult to cure, and it is one of the four major chronic diseases in my country. The research results show that environmental pollution, smoking and respiratory infection are the main causes of COPD. Since the early symptoms of COPD are not obvious, most patients are easily mistaken for common respiratory infections and do not pay attention to them. They do not seek medical treatment until symptoms such as shortness of breath appear. At this time, the lung function of patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K47/60A61K47/69A61K33/42A61K31/722A61P11/00A61P31/04A61P11/06A61P35/00
CPCA61K47/61A61K47/60A61K47/6939A61K33/42A61K31/722A61P11/00A61P31/04A61P11/06A61P35/00
Inventor 李志斌喻学锋
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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